The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review

Osteosarcoma is a malignant tumor of bone that leads to poor mortality and morbidity. Management of this cancer through conventional methods involves invasive treatment options that place patients at an increased risk of adverse events. The use of hydrogels to target osteosarcoma has shown promising...

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Bibliographic Details
Published in:	Gels Vol. 9; no. 4; p. 274
Main Authors:	Tharakan, Shebin, Raja, Iman, Pietraru, Annette, Sarecha, Elina, Gresita, Andrei, Petcu, Eugen, Ilyas, Azhar, Hadjiargyrou, Michael
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25-03-2023 MDPI
Subjects:	Biomechanics bone Bone cancer Cancer Cancer therapies Chemotherapy Clinical trials Controlled release Drug delivery systems Drug therapy drug-delivery Drugs Fractures Health aspects Hydrogels Immunotherapy In vivo methods and tests Kinases Literature reviews Lymphocytes Metastasis Mutation Nanomaterials Narratives Older people Osteosarcoma Patients Polymers Radiation Regeneration (physiology) Review scaffold Stimuli Surgery Surgical outcomes Tissue engineering Tumors Vascular endothelial growth factor Vehicles drug-delivery tissue engineering bone hydrogels scaffold osteosarcoma
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Summary:	Osteosarcoma is a malignant tumor of bone that leads to poor mortality and morbidity. Management of this cancer through conventional methods involves invasive treatment options that place patients at an increased risk of adverse events. The use of hydrogels to target osteosarcoma has shown promising results both in vitro and in vivo to eradicate tumor cells while promoting bone regeneration. The loading of hydrogels with chemotherapeutic drugs provides a route for site-specific targeted therapy for osteosarcoma. Current studies demonstrate tumor regression in vivo and lysis of tumor cells in vitro when exposed to doped hydrogel scaffolds. Additionally, novel stimuli-responsive hydrogels are able to react with the tissue microenvironment to facilitate the controlled release of anti-tumor drugs and with biomechanical properties that can be modulated. This narrative review of the current literature discusses both in vitro and in vivo studies of different hydrogels, including stimuli-responsive, designed to treat bone osteosarcoma. Future applications to address patient treatment for this bone cancer are also discussed.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2310-2861 2310-2861
DOI:	10.3390/gels9040274