Search Results - "Sardis, Marios Frantzeskos"

SecA: a tale of two protomers by Sardis, Marios Frantzeskos, Economou, Anastassios

“…Bacteria, Archaea and Eukaryotes have evolved a plethora of mechanisms to translocate proteins across their various membranes. The bacterial Sec pathway is…”
Get full text

Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism by Krishnamurthy, Srinath, Sardis, Marios-Frantzeskos, Eleftheriadis, Nikolaos, Chatzi, Katerina E., Smit, Jochem H., Karathanou, Konstantina, Gouridis, Giorgos, Portaliou, Athina G., Bondar, Ana-Nicoleta, Karamanou, Spyridoula, Economou, Anastassios

“…Protein machines undergo conformational motions to interact with and manipulate polymeric substrates. The Sec translocase promiscuously recognizes, becomes…”
Get full text

SecA-mediated targeting and translocation of secretory proteins by Chatzi, Katerina E., Sardis, Marios Frantzeskos, Economou, Anastassios, Karamanou, Spyridoula

“…More than 30years of research have revealed that the dynamic nanomotor SecA is a central player in bacterial protein secretion. SecA associates with the SecYEG…”
Get full text

Quaternary Dynamics of the SecA Motor Drive Translocase Catalysis by Gouridis, Giorgos, Karamanou, Spyridoula, Sardis, Marios Frantzeskos, Schärer, Martin Alexander, Capitani, Guido, Economou, Anastassios

“…Most secretory preproteins exit bacterial cells through the protein translocase, comprising the SecYEG channel and the dimeric peripheral ATPase motor SecA…”
Get full text

Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening by De Waelheyns, Evelien, Segers, Kenneth, Sardis, Marios Frantzeskos, Anné, Jozef, Nicolaes, Gerry A F, Economou, Anastassios

“…The rapid rise of antibiotic-resistant bacteria is one of the major concerns in modern medicine. Therefore, to treat bacterial infections, there is an urgent…”
Get full text

Preprotein mature domains contain translocase targeting signals that are essential for secretion by Chatzi, Katerina E, Sardis, Marios Frantzeskos, Tsirigotaki, Alexandra, Koukaki, Marina, Šoštarić, Nikolina, Konijnenberg, Albert, Sobott, Frank, Kalodimos, Charalampos G, Karamanou, Spyridoula, Economou, Anastassios

“…Secretory proteins are only temporary cytoplasmic residents. They are typically synthesized as proteins, carrying signal peptides N-terminally fused to their…”
Get full text

Preprotein Conformational Dynamics Drive Bivalent Translocase Docking and Secretion by Sardis, Marios Frantzeskos, Tsirigotaki, Alexandra, Chatzi, Katerina Elias, Portaliou, Athina George, Gouridis, Giorgos, Karamanou, Spyridoula, Economou, Anastassios

“…Most bacterial secretory proteins destined beyond the plasma membrane are secreted post-translationally by the Sec translocase. In the first step of…”
Get full text

The Escherichia coli Peripheral Inner Membrane Proteome by Papanastasiou, Malvina, Orfanoudaki, Georgia, Koukaki, Marina, Kountourakis, Nikos, Sardis, Marios Frantzeskos, Aivaliotis, Michalis, Karamanou, Spyridoula, Economou, Anastassios

“…Biological membranes are essential for cell viability. Their functional characteristics strongly depend on their protein content, which consists of…”
Get full text

Long-Lived Folding Intermediates Predominate the Targeting-Competent Secretome by Tsirigotaki, Alexandra, Chatzi, Katerina E., Koukaki, Marina, De Geyter, Jozefien, Portaliou, Athina G., Orfanoudaki, Georgia, Sardis, Marios Frantzeskos, Trelle, Morten Beck, Jørgensen, Thomas J.D., Karamanou, Spyridoula, Economou, Anastassios

“…Secretory preproteins carry signal peptides fused amino-terminally to mature domains. They are post-translationally targeted to cross the plasma membrane in…”
Get full text

Rapid label-free quantitative analysis of the E. coli BL21(DE3) inner membrane proteome by Papanastasiou, Malvina, Orfanoudaki, Georgia, Kountourakis, Nikos, Koukaki, Marina, Sardis, Marios Frantzeskos, Aivaliotis, Michalis, Tsolis, Konstantinos C., Karamanou, Spyridoula, Economou, Anastassios

“…Biological membranes define cells and cellular compartments and are essential in regulating bidirectional flow of chemicals and signals. Characterizing their…”
Get full text