Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon

This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red...

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Bibliographic Details
Published in:	The Brazilian journal of infectious diseases Vol. 14; no. 4; pp. 410 - 412
Main Authors:	Ramos Júnior, Wilson M, Sardinha, José FJ, Costa, Mônica RF, Santana, Marli S, Alecrim, Maria GC, Lacerda, Marcus VG
Format:	Journal Article
Language:	English
Published:	Brazilian Society of Infectious Diseases 01-08-2010 Elsevier
Subjects:	hemolysis INFECTIOUS DISEASES malaria Plasmodium vivax primaquine treatment Plasmodium vivax treatment primaquine malaria hemolysis
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Summary:	This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
ISSN:	1413-8670 1678-4391
DOI:	10.1590/S1413-86702010000400017