Complement Activation and Interleukin Response in Major Abdominal Surgery

The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. The study design was prospective and randomised. Fifty...

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Bibliographic Details
Published in:	Scandinavian journal of immunology Vol. 75; no. 5; pp. 510 - 516
Main Authors:	Kvarnström, A. L., Sarbinowski, R. T., Bengtson, J.-P., Jacobsson, L. M., Bengtsson, A. L.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-05-2012
Subjects:	Aged Anestesi och intensivvård Anesthesia Anesthesia, Inhalation Anesthesia, Intravenous Anesthesiology and Intensive Care Anesthetics - administration & dosage Cancer Colon - surgery colorectal surgery Complement Activation cytokines Female fentanyl Fentanyl - pharmacology Humans Inflammatory bowel diseases inhalation anaesthesia Interleukin 1 Interleukin 10 Interleukin 4 Interleukin 6 Interleukin 8 Interleukin-10 - biosynthesis Interleukin-10 - blood Interleukin-1beta - biosynthesis Interleukin-1beta - blood Interleukin-4 - biosynthesis Interleukin-4 - blood Interleukin-6 - biosynthesis Interleukin-6 - blood Interleukin-8 - biosynthesis Interleukin-8 - blood Interleukins - biosynthesis Intravenous administration Male Methyl Ethers - pharmacology Middle Aged Piperidines - pharmacology Propofol Propofol - pharmacology remifentanil Sevoflurane Surgery total intravenous anaesthesia Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - blood
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Summary:	The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. The study design was prospective and randomised. Fifty patients undergoing open major colorectal surgery due to cancer disease or inflammatory bowel disease were studied. Twenty‐five patients were given total intravenous anaesthesia (TIVA) with propofol and remifentanil, and 25 patients were given inhalational anaesthesia with sevoflurane and fentanyl. To determine complement activation (C3a and SC5b‐9) and the release of pro‐ and anti‐inflammatory interleukins (tumour necrosis factor‐a (TNF‐a)), interleukin‐1b (IL‐1b), IL‐6, IL‐8, IL‐4 and IL‐10), blood samples were drawn preoperatively, 60 minutes after start of surgery, 30 minutes after end of surgery and 24 hours postoperatively. Complement was activated and pro‐inflammatory interleukins (IL‐6 and IL‐8) and anti‐inflammatory interleukins (IL‐10) were released during major colorectal surgery. There was no significant difference between TIVA and inhalational anaesthesia regarding complement activation and cytokine release. Major colorectal surgery leads to activation of the complement cascade and the release of both pro‐inflammatory and anti‐inflammatory cytokines. There are no significant differences between total intravenous anaesthesia (TIVA) with propofol and remifentanil and inhalational anaesthesia with sevoflurane and fentanyl regarding complement activation and the release of pro‐ and anti‐inflammatory interleukins.
Bibliography:	ArticleID:SJI2672 ark:/67375/WNG-MK2RZCJ5-6 istex:63D74FB943FE4DE57CC89D1D8A586877940C7B2B ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-News-1 ObjectType-Feature-3
ISSN:	0300-9475 1365-3083 1365-3083
DOI:	10.1111/j.1365-3083.2012.02672.x