Search Results - "Saravanan, Karuppagounder S."

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis by Zille, Marietta, Karuppagounder, Saravanan S, Chen, Yingxin, Gough, Peter J, Bertin, John, Finger, Joshua, Milner, Teresa A, Jonas, Elizabeth A, Ratan, Rajiv R

“…BACKGROUND AND PURPOSE—Intracerebral hemorrhage leads to disability or death with few established treatments. Adverse outcomes after intracerebral hemorrhage…”
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Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate by Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V

“…Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the…”
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Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases by Rroji, Orjon, Kumar, Amit, Karuppagounder, Saravanan S., Ratan, Rajiv R.

“…A major thrust of our laboratory has been to identify how physiological stress is transduced into transcriptional responses that feed back to overcome the…”
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Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics? by Karuppagounder, Saravanan S, Ratan, Rajiv R

“…A major challenge in developing stroke therapeutics that augment adaptive pathways to stress has been to identify targets that can activate compensatory…”
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The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease by Aimé, Pascaline, Karuppagounder, Saravanan S., Rao, Apeksha, Chen, Yingxin, Burke, Robert E., Ratan, Rajiv R., Greene, Lloyd A.

“…Identifying disease-causing pathways and drugs that target them in Parkinson's disease (PD) has remained challenging. We uncovered a PD-relevant pathway in…”
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Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke by Speer, Rachel E., Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama F., Kumar, Amit, Brand, David, Smirnova, Natalya, Gazaryan, Irina, Khim, Soah J., Ratan, Rajiv R.

“…Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington disease are leading causes of death and long-term disability in…”
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Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors by Zille, Marietta, Kumar, Amit, Kundu, Nandini, Bourassa, Megan W, Wong, Victor S C, Willis, Dianna, Karuppagounder, Saravanan S, Ratan, Rajiv R

“…Ferroptotic death is a mechanism for tumor suppression by pharmacological inhibitors that target the X transporter (cystine/glutamate antiporter) in a host of…”
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Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery by Wei, George Z, Saraswat Ohri, Sujata, Khattar, Nicolas K, Listerman, Adam W, Doyle, Catherine H, Andres, Kariena R, Karuppagounder, Saravanan S, Ratan, Rajiv R, Whittemore, Scott R, Hetman, Michal

“…Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events…”
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HIF1α stabilization in hypoxia is not oxidant-initiated by Kumar, Amit, Vaish, Manisha, Karuppagounder, Saravanan S, Gazaryan, Irina, Cave, John W, Starkov, Anatoly A, Anderson, Elizabeth T, Zhang, Sheng, Pinto, John T, Rountree, Austin M, Wang, Wang, Sweet, Ian R, Ratan, Rajiv R

“…Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct…”
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Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition by Sleiman, Sama F, Olson, David E, Bourassa, Megan W, Karuppagounder, Saravanan S, Zhang, Yan-Ling, Gale, Jennifer, Wagner, Florence F, Basso, Manuela, Coppola, Giovanni, Pinto, John T, Holson, Edward B, Ratan, Rajiv R

“…Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and…”
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Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism by Karuppagounder, Saravanan S, Shi, Qingli, Xu, Hui, Gibson, Gary E

“…Abstract Abnormalities in oxidative metabolism and reductions of thiamine-dependent enzymes accompany many age-related neurodegenerative diseases. Thiamine…”
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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke by Alim, Ishraq, Caulfield, Joseph T., Chen, Yingxin, Swarup, Vivek, Geschwind, Daniel H., Ivanova, Elena, Seravalli, Javier, Ai, Youxi, Sansing, Lauren H., Ste.Marie, Emma J., Hondal, Robert J., Mukherjee, Sushmita, Cave, John W., Sagdullaev, Botir T., Karuppagounder, Saravanan S., Ratan, Rajiv R.

“…Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress in cancer, heat stress in plants, and hemorrhagic stroke. A…”
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Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease by Saravanan, Karuppagounder S., Sindhu, Kizhakke M., Mohanakumar, Kochupurackal P.

“…We examined in Sprague–Dawley rats whether intranigral administration of complex-I inhibitor, rotenone, produces biochemical lesions in the striatum similar to…”
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Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease by Smirnova, Natalya A, Kaidery, Navneet Ammal, Hushpulian, Dmitry M, Rakhman, Ilay I, Poloznikov, Andrey A, Tishkov, Vladimir I, Karuppagounder, Saravanan S, Gaisina, Irina N, Pekcec, Anton, Leyen, Klaus Van, Kazakov, Sergey V, Yang, Lichuan, Thomas, Bobby, Ratan, Rajiv R, Gazaryan, Irina G

“…Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase…”
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N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice by Karuppagounder, Saravanan S., Alin, Lauren, Chen, Yingxin, Brand, David, Bourassa, Megan W., Dietrich, Kristen, Wilkinson, Cassandra M., Nadeau, Colby A., Kumar, Amit, Perry, Steve, Pinto, John T., Darley‐Usmar, Victor, Sanchez, Stephanie, Milne, Ginger L., Pratico, Domenico, Holman, Theodore R., Carmichael, S. Thomas, Coppola, Giovanni, Colbourne, Frederick, Ratan, Rajiv R.

“…Objectives N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox modulatory compound currently in trials for many neurological and psychiatric…”
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N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E 2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice by Karuppagounder, Saravanan S, Alin, Lauren, Chen, Yingxin, Brand, David, Bourassa, Megan W, Dietrich, Kristen, Wilkinson, Cassandra M, Nadeau, Colby A, Kumar, Amit, Perry, Steve, Pinto, John T, Darley-Usmar, Victor, Sanchez, Stephanie, Milne, Ginger L, Pratico, Domenico, Holman, Theodore R, Carmichael, S Thomas, Coppola, Giovanni, Colbourne, Frederick, Ratan, Rajiv R

“…N-acetylcysteine (NAC) is a clinically approved thiol-containing redox modulatory compound currently in trials for many neurological and psychiatric disorders…”
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Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis by Zille, Marietta, Oses-Prieto, Juan A, Savage, Sara R, Karuppagounder, Saravanan S, Chen, Yingxin, Kumar, Amit, Morris, John H, Scheidt, Karl A, Burlingame, Alma L, Ratan, Rajiv R

“…Ferroptosis is a caspase-independent, iron-dependent form of regulated necrosis extant in traumatic brain injury, Huntington disease, and hemorrhagic stroke…”
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2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience by Kumar, Amit, Karuppagounder, Saravanan S., Chen, Yingxin, Corona, Carlo, Kawaguchi, Riki, Cheng, Yuyan, Balkaya, Mustafa, Sagdullaev, Botir T., Wen, Zhexing, Stuart, Charles, Cho, Sunghee, Ming, Guo-li, Tuvikene, Jürgen, Timmusk, Tõnis, Geschwind, Daniel H., Ratan, Rajiv R.

“…Intermittent fasting (IF) is a diet with salutary effects on cognitive aging, Alzheimer’s disease (AD), and stroke. IF restricts a number of nutrient…”
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Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease by Karuppagounder, Saravanan S., Pinto, John T., Xu, Hui, Chen, Huan-Lian, Beal, M. Flint, Gibson, Gary E.

“…Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses a wide range of biological effects. Since resveratrol's properties…”
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Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models by Karuppagounder, Saravanan S, Alim, Ishraq, Khim, Soah J, Bourassa, Megan W, Sleiman, Sama F, John, Roseleen, Thinnes, Cyrille C, Yeh, Tzu-Lan, Demetriades, Marina, Neitemeier, Sandra, Cruz, Dana, Gazaryan, Irina, Killilea, David W, Morgenstern, Lewis, Xi, Guohua, Keep, Richard F, Schallert, Timothy, Tappero, Ryan V, Zhong, Jian, Cho, Sunghee, Maxfield, Frederick R, Holman, Theodore R, Culmsee, Carsten, Fong, Guo-Hua, Su, Yijing, Ming, Guo-li, Song, Hongjun, Cave, John W, Schofield, Christopher J, Colbourne, Frederick, Coppola, Giovanni, Ratan, Rajiv R

“…Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators…”
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