Search Results - "Saravanan, Bharath"

A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer by Walavalkar, Kaivalya, Saravanan, Bharath, Singh, Anurag Kumar, Jayani, Ranveer Singh, Nair, Ashwin, Farooq, Umer, Islam, Zubairul, Soota, Deepanshu, Mann, Rajat, Shivaprasad, Padubidri V., Freedman, Matthew L., Sabarinathan, Radhakrishnan, Haiman, Christopher A., Notani, Dimple

“…Genetic variation at the 8q24 locus is linked with the greater susceptibility to prostate cancer in men of African ancestry. One such African ancestry specific…”
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An interdependent network of functional enhancers regulates transcription and EZH2 loading at the INK4a/ARF locus by Farooq, Umer, Saravanan, Bharath, Islam, Zubairul, Walavalkar, Kaivalya, Singh, Anurag Kumar, Jayani, Ranveer Singh, Meel, Sweety, Swaminathan, Sudha, Notani, Dimple

“…The INK4a/ARF locus encodes important cell-cycle regulators p14ARF, p15INK4b, and p16INK4a. The neighboring gene desert to this locus is the most reproducible…”
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Ligand dependent gene regulation by transient ERα clustered enhancers by Saravanan, Bharath, Soota, Deepanshu, Islam, Zubairul, Majumdar, Sudeshna, Mann, Rajat, Meel, Sweety, Farooq, Umer, Walavalkar, Kaivalya, Gayen, Srimonta, Singh, Anurag Kumar, Hannenhalli, Sridhar, Notani, Dimple

“…Unliganded Estrogen receptor alpha (ERα) has been implicated in ligand-dependent gene regulation. Upon ligand exposure, ERα binds to several EREs relatively…”
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Anti-coagulation therapy on COVID-19 patients: A systematic review and meta-analysis by Muthiah, Aravind, Srikumar, Shabarini, Saravanan, Praveen, Perumal, Shridharan

“…A once often neglected virus from common practice has been demanding the attention of all researchers for the past decade ever since it started to infect…”
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RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for transcriptional regulation by Soota, Deepanshu, Saravanan, Bharath, Mann, Rajat, Kharbanda, Tripti, Notani, Dimple

“…Transcription factors (TFs) regulate gene expression by binding with varying strengths to DNA via their DNA-binding domain. Additionally, some TFs also…”
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Active enhancers strengthen insulation by RNA-mediated CTCF binding at chromatin domain boundaries by Islam, Zubairul, Saravanan, Bharath, Walavalkar, Kaivalya, Farooq, Umer, Singh, Anurag Kumar, Radhakrishnan, Sabarinathan, Thakur, Jitendra, Pandit, Awadhesh, Henikoff, Steven, Notani, Dimple

“…Vertebrate genomes are partitioned into chromatin domains or topologically associating domains (TADs), which are typically bound by head-to-head pairs of CTCF…”
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AML-515 Efficacy of FLT3 Inhibitors in Acute Myeloid Leukemia (AML): A Network Meta-Analysis of Randomized Controlled Trials by Jha, Tathagata, Goel, Archit, Gupta, Ishan, Govekar, Siddhant, Bharath Saravanan, Praveen, Sharma, Sakshi, Suresh, Vinay

“…Fms-like tyrosine kinase 3 (FLT3) is crucial for hematopoietic cell proliferation and differentiation. FLT3 mutations occur in about one-third of acute myeloid…”
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Efficacy of FLT3 Inhibitors in Acute Myeloid Leukemia (AML): A Network Meta-Analysis of Randomized Controlled Trials by Jha, Tathagata, Goel, Archit, Gupta, Ishan, Govekar, Siddhant, Bharath Saravanan, Praveen, Sharma, Sakshi, Suresh, Vinay

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Ligand dependent gene regulation by transient ER[alpha] clustered enhancers by Saravanan, Bharath, Soota, Deepanshu, Islam, Zubairul, Majumdar, Sudeshna, Mann, Rajat, Meel, Sweety, Farooq, Umer, Walavalkar, Kaivalya, Gayen, Srimonta, Singh, Anurag Kumar, Hannenhalli, Sridhar, Notani, Dimple

“…Unliganded Estrogen receptor alpha (ER[alpha]) has been implicated in ligand-dependent gene regulation. Upon ligand exposure, ER[alpha] binds to several EREs…”
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Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies by Venkatesan, Vigneshwaran, Christopher, Abisha Crystal, Rhiel, Manuel, Azhagiri, Manoj Kumar K., Babu, Prathibha, Walavalkar, Kaivalya, Saravanan, Bharath, Andrieux, Geoffroy, Rangaraj, Sumathi, Srinivasan, Saranya, Karuppusamy, Karthik V., Jacob, Annlin, Bagchi, Abhirup, Pai, Aswin Anand, Nakamura, Yukio, Kurita, Ryo, Balasubramanian, Poonkuzhali, Pai, Rekha, Marepally, Srujan Kumar, Mohankumar, Kumarasamypet Murugesan, Velayudhan, Shaji R., Boerries, Melanie, Notani, Dimple, Cathomen, Toni, Srivastava, Alok, Thangavel, Saravanabhavan

“…Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult…”
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Study the relationship between left atrial (LA) volume and LV diastolic dysfunction and LV hypertrophy: Correlate LA volume with cardiovascular risk factors by Pawar, Shubhadarshini G., Saravanan, Praveen Bharath, Gulati, Shipra, Pati, Shefali, Joshi, Muskan, Salam, Ajal, Khan, Nida

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Study the relationship between left atrial (LA) volume and left ventricular (LV) diastolic dysfunction and LV hypertrophy: Correlate LA volume with cardiovascular risk factors by Pawar, Shubhadarshini G., Saravanan, Praveen Bharath, Gulati, Shipra, Pati, Shefali, Joshi, Muskan, Salam, Ajal, Khan, Nida

“…Heart failure (HF) with normal ejection fraction - the isolated diastolic heart failure, depicts increasing prevalence and health care burden in recent times…”
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The association of Pulmonary Hypertension and right ventricular systolic function – updates in diagnosis and treatment by Pawar, Shubhadarshini G., Khan, Nida, Salam, Ajal, Joshi, Muskan, Saravanan, Praveen Bharath, Pandey, Shreya

“…Right ventricular (RV) systolic function is an essential but neglected component in cardiac evaluation, and its importance to the contribution to overall…”
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