Search Results - "Saravanabavan, Sayanthooran"

Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease by Saravanabavan, Sayanthooran, Rangan, Gopala K

“…Increased DNA damage response (DDR) signaling in kidney cyst-lining epithelial cells (CECs) may provide an opportunity for cell-specific therapeutic targeting…”
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Role of DNA-Dependent Protein Kinase in Mediating Cyst Growth in Autosomal Dominant Polycystic Kidney Disease by Chandra, Ashley N., Saravanabavan, Sayanthooran, Rangan, Gopala K.

“…DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein involved in DNA damage response (DDR) signaling that may mediate kidney cyst growth in…”
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Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease by Zhang, Jennifer Qin Jing, Burgess, Jane, Stepanova, Daria, Saravanabavan, Sayanthooran, Wong, Annette T.Y., Kaldis, Philipp, Rangan, Gopala K.

“…A hallmark of polycystic kidney diseases (PKDs) is aberrant proliferation, which leads to the formation and growth of renal cysts. Proliferation is mediated by…”
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ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation by Ragagnin, Audrey M. G., Sundaramoorthy, Vinod, Farzana, Fabiha, Gautam, Shashi, Saravanabavan, Sayanthooran, Takalloo, Zeinab, Mehta, Prachi, Do-Ha, Dzung, Parakh, Sonam, Shadfar, Sina, Hunter, Julie, Vidal, Marta, Jagaraj, Cyril J., Brocardo, Mariana, Konopka, Anna, Yang, Shu, Rayner, Stephanie L., Williams, Kelly L., Blair, Ian P., Chung, Roger S., Lee, Albert, Ooi, Lezanne, Atkin, Julie D.

“…Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia…”
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Long-term dietary nitrate supplementation does not reduce renal cyst growth in experimental autosomal dominant polycystic kidney disease by Zhang, Jennifer Q J, Saravanabavan, Sayanthooran, Cheng, Kai Man, Raghubanshi, Aarya, Chandra, Ashley N, Munt, Alexandra, Rayner, Benjamin, Zhang, Yunjia, Chau, Katrina, Wong, Annette T Y, Rangan, Gopala K

“…Augmentation of endogenous nitric oxide (NO) synthesis, either by the classical L-arginine-NO synthase pathway, or the recently discovered entero-salivary…”
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Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial by Sagar, Priyanka S, Munt, Alexandra, Saravanabavan, Sayanthooran, Vahedi, Farnoosh Asghar, Elhindi, James, Nguyen, Beatrice, Chau, Katrina, Harris, David C, Lee, Vincent, Sud, Kamal, Wong, Nikki, Rangan, Gopala K

“…In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice…”
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Transcriptome analysis supports viral infection and fluoride toxicity as contributors to chronic kidney disease of unknown etiology (CKDu) in Sri Lanka by Sayanthooran, Saravanabavan, Gunerathne, Lishanthe, Abeysekera, Tilak D. J., Magana-Arachchi, Dhammika N.

“…Purpose Chronic kidney disease of unknown etiology (CKDu), having epidemic characteristics, is being diagnosed increasingly in certain tropical regions of the…”
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Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease by Zhang, Jennifer Q J, Saravanabavan, Sayanthooran, Rangan, Gopala K

“…The DNA damage response (DDR) pathway is upregulated in autosomal dominant polycystic kidney disease (ADPKD) but its functional role is not known. The…”
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Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease by Sagar, Priyanka S., Saravanabavan, Sayanthooran, Munt, Alexandra, Wong, Annette T. Y., Rangan, Gopala K.

“…Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the…”
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Upregulation of Oxidative Stress Related Genes in a Chronic Kidney Disease Attributed to Specific Geographical Locations of Sri Lanka by Abeysekera, Tilak D. J., Gunerathne, Lishanthe, Magana-Arachchi, Dhammika N., Sayanthooran, Saravanabavan, Sooriyapathirana, Suneth S.

“…Objective. To infer the influence of internal and external oxidative stress in chronic kidney disease patients of unknown etiology (CKDu) in Sri Lanka, by…”
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Assessment of Dietary Sodium Intake Using the Scored Salt Questionnaire in Autosomal Dominant Polycystic Kidney Disease by Wong, Annette T Y, Munt, Alexandra, Allman-Farinelli, Margaret, Badve, Sunil V, Boudville, Neil, Coolican, Helen, Chandra, Ashley N, Coulshed, Susan, Fernando, Mangalee, Grantham, Jared, Haloob, Imad, Harris, David C H, Hawley, Carmel M, Holt, Jane, Johnson, David W, Kumar, Karthik, Lee, Vincent W, Lonergan, Maureen, Mai, Jun, Rangan, Anna, Roger, Simon D, Saravanabavan, Sayanthooran, Sud, Kamal, Torres, Vicente E, Vilayur, Eswari, Zhang, Jennifer Q J, Rangan, Gopala K

“…The excess intake of dietary sodium is a key modifiable factor for reducing disease progression in autosomal dominant polycystic kidney disease (ADPKD). The…”
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Culture of Three-Dimensional Madin-Darby Canine Kidney (MDCK) Cysts for In Vitro Drug Testing in Polycystic Kidney Disease by Saravanabavan, Sayanthooran, Rangan, Gopala K

“…The formation and growth of kidney cysts (fluid-filled structures lined by epithelial cells) is the primary pathological abnormality in polycystic kidney…”
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Molecular hallmarks of ageing in amyotrophic lateral sclerosis by Jagaraj, Cyril Jones, Shadfar, Sina, Kashani, Sara Assar, Saravanabavan, Sayanthooran, Farzana, Fabiha, Atkin, Julie D.

“…Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain, brainstem, and…”
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Possible role of the mitochondrial genome in the pathogenesis of autosomal dominant polycystic kidney disease by Saravanabavan, Sayanthooran, Rangan, Gopala K.

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic renal disease in adults and is due to heterozygous germ line variants in…”
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Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study by Sayanthooran, Saravanabavan, Magana-Arachchi, Dhammika N, Gunerathne, Lishanthe, Abeysekera, Tilak

“…In Sri Lanka, there exists chronic kidney disease of both known (CKD) and unknown etiologies (CKDu). Identification of novel biomarkers that are customized to…”
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Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease by Zhang, Jennifer Q.J., Saravanabavan, Sayanthooran, Chandra, Ashley N., Munt, Alexandra, Wong, Annette T.Y., Harris, Peter C., Harris, David C.H., McKenzie, Paul, Wang, Yiping, Rangan, Gopala K.

“…DNA damage and alterations in DNA damage response (DDR) signaling could be one of the molecular mechanisms mediating focal kidney cyst formation in autosomal…”
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C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD by Sultana, Jessica, Ragagnin, Audrey M G, Parakh, Sonam, Saravanabavan, Sayanthooran, Soo, Kai Ying, Vidal, Marta, Jagaraj, Cyril Jones, Ding, Kunjie, Wu, Sharlynn, Shadfar, Sina, Don, Emily K, Deva, Anand, Nicholson, Garth, Rowe, Dominic B, Blair, Ian, Yang, Shu, Atkin, Julie D

“…Hexanucleotide repeat expansions (HREs) in the chromosome 9 open reading frame 72 (C9orf72) gene are the most frequent genetic cause of amyotrophic lateral…”
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Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease: PO2537 by Rangan, Gopi, Wong, Annette, Munt, Alexandra, Zhang, Jennifer, Saravanabavan, Sayanthooran, Allman-Farinelli, Margaret, Badve, Sunil, Boudville, Neil, Erickson, Bradley J., Fernando, Mangalee R., Foster, Sheryl L., Gregory, Adriana, Haloob, Imad A., Hawley, Carmel, Johnson, David W., Kline, Timothy L., Lee, Vincent W., Lonergan, Maureen A., Pascoe, Elaine, Rangan, Anna M., Roger, Simon D., Sud, Kamal, Torres, Vicente E., Adinarayanan, Sundareswari V., Harris, David

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Clinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review by Rangan, Gopala K, Dorani, Nilofar, Zhang, Miranda M, Abu-Zarour, Lara, Lau, Ho Ching, Munt, Alexandra, Chandra, Ashley N, Saravanabavan, Sayanthooran, Rangan, Anna, Zhang, Jennifer Q J, Howell, Martin, Wong, Annette TY

“…IntroductionExcessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical…”
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The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease by Zhang, Jennifer Q J, Saravanabavan, Sayanthooran, Munt, Alexandra, Wong, Annette T Y, Harris, David C, Harris, Peter C, Wang, Yiping, Rangan, Gopala K

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease and is caused by heterozygous germ-line mutations in either…”
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