Green Nanotechnology-based Gold Nanomaterials for Hepatic Cancer Therapeutics: A Systematic Review

The objective of the current study was to systematically review the anticancer activity of green synthesized gold nanoparticles (AuNPs) against hepatic cancer cells. The articles were identified through electronic databases, including PubMed, Scopus, Embase, Web of Science, Science Direct, ProQuest,...

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Bibliographic Details
Published in:	Iranian journal of pharmaceutical research : IJPR Vol. 19; no. 3; pp. 3 - 17
Main Authors:	Barabadi, Hamed, Webster, Thomas J, Vahidi, Hossein, Sabori, Hamed, Damavandi Kamali, Kaveh, Jazayeri Shoushtari, Fereshteh, Mahjoub, Mohammad Ali, Rashedi, Masoumeh, Mostafavi, Ebrahim, Cruz, David Medina, Hosseini, Omid, Saravana, Muthupandian
Format:	Journal Article
Language:	English
Published:	Iran Shaheed Beheshti University of Medical Sciences 01-01-2020
Subjects:	Review Hepatic cancer Nanotoxicity Biosynthesis Gold nanoparticles Anticancer activity
Online Access:	Get full text
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Summary:	The objective of the current study was to systematically review the anticancer activity of green synthesized gold nanoparticles (AuNPs) against hepatic cancer cells. The articles were identified through electronic databases, including PubMed, Scopus, Embase, Web of Science, Science Direct, ProQuest, and Cochrane. In total, 20 articles were found eligible to enter into our systematic review. Our findings showed that 65% of the articles used herbal extracts for the synthesis of AuNPs. Significantly, almost all of the articles stated the biofabrication of AuNPs below 100 nm in diameter. Impressively, most of the studies showed significant anticancer activity against HepG2 cells. Molecular studies stated the induction of apoptosis through the AuNPs-treated cells. We provided valuable information about the molecular mechanisms of AuNPs-induced cytotoxicity against HepG2 cells as well as their biocompatibility. The studies represented that AuNPs can be effective as anticancer drug nanocarrier for drug delivery systems. In addition, AuNP surface functionalization provides an opportunity to design multifunctional nanoparticles by conjugating them to diagnostic and/or therapeutic agents for theranostic purposes. Overall, our findings depicted considerable biogenic AuNPs-induced cytotoxicity, however, future studies should assess the anticancer activity of biogenic AuNPs through studies, which was missing from such studies.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1735-0328 1726-6890
DOI:	10.22037/ijpr.2020.113820.14504