The Molecular Genetic Expression as a Novel Biomarker in the Evaluation and Monitoring of Patients With Osteosarcoma-Subtype Bone Cancer Disease

One of the leading causes of death among patients with malignancies is represented by bone cancer. According to current studies, the leading cause of death among these patients is represented by late diagnosis, poor response to therapy, and the lack of accuracy in terms of clinical evaluation. In th...

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Bibliographic Details
Published in:	Biochemical genetics Vol. 55; no. 4; pp. 291 - 299
Main Authors:	Hutanu, Delia, Popescu, Roxana, Stefanescu, Horatiu, Pirtea, Laurentiu, Candea, Adrian, Sarau, Cristi, Boruga, Ovidiu, Mehdi, Lagtonbi, Ciuca, Ioana, Tanasescu, Sonia
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-08-2017 Springer Nature B.V
Subjects:	Biochemistry Biocompatibility Biomarkers Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Bone cancer Bone Neoplasms - genetics Bone Neoplasms - pathology Cancer Death Diagnosis Gene Expression Regulation, Neoplastic Gene therapy Human Genetics Humans Medical Microbiology MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Monitoring Osteosarcoma Osteosarcoma - genetics Osteosarcoma - pathology Patients Review Sarcoma Zoology miRNA expression Bone cancer Epigenetic biomarkers
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Summary:	One of the leading causes of death among patients with malignancies is represented by bone cancer. According to current studies, the leading cause of death among these patients is represented by late diagnosis, poor response to therapy, and the lack of accuracy in terms of clinical evaluation. In this regard, there have been developed a series of methods of diagnosis and evaluation, the most investigated being represented by miRNA expression. In this updated work, we want to present a series of changes in the expression of miRNAs in bone cancer. Moreover, we want to present the implications of miRNAs in targeted therapy in such patients. Studies available in scientific databases such as PubMed and Scopus were examined. The studies were searched using the keywords “miRNAs expression”, “bone cancer”, “genetic therapy” and “genetic biomarkers.” For the evaluation and monitoring of bone cancer, the expression of miRNAs can be successfully used due to increased specificity. Using miRNAs as gene therapy can be also considered a therapeutic method of the future, mainly due to selective and targeted response of the body.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0006-2928 1573-4927
DOI:	10.1007/s10528-017-9801-1