Search Results - "Saratsis, Amanda M"

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome by Panwalkar, Pooja, Clark, Jonathan, Ramaswamy, Vijay, Hawes, Debra, Yang, Fusheng, Dunham, Christopher, Yip, Stephen, Hukin, Juliette, Sun, Yilun, Schipper, Matthew J., Chavez, Lukas, Margol, Ashley, Pekmezci, Melike, Chung, Chan, Banda, Adam, Bayliss, Jill M., Curry, Sarah J., Santi, Mariarita, Rodriguez, Fausto J., Snuderl, Matija, Karajannis, Matthias A., Saratsis, Amanda M., Horbinski, Craig M., Carret, Anne-Sophie, Wilson, Beverly, Johnston, Donna, Lafay-Cousin, Lucie, Zelcer, Shayna, Eisenstat, David, Silva, Marianna, Scheinemann, Katrin, Jabado, Nada, McNeely, P. Daniel, Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Hawkins, Cynthia, Korshunov, Andrey, Judkins, Alexander R., Venneti, Sriram

“…Posterior fossa ependymomas (EPN_PF) in children comprise two morphologically identical, but biologically distinct tumor entities. Group-A (EPN_PFA) tumors…”
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Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR by Li, Daphne, Bonner, Erin R., Wierzbicki, Kyle, Panditharatna, Eshini, Huang, Tina, Lulla, Rishi, Mueller, Sabine, Koschmann, Carl, Nazarian, Javad, Saratsis, Amanda M.

“…Diffuse midline glioma (DMG) is a highly morbid pediatric brain tumor. Up to 80% of DMGs harbor mutations in histone H3-encoding genes, associated with poor…”
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Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma by Huang, Tina Y, Piunti, Andrea, Lulla, Rishi R, Qi, Jin, Horbinski, Craig M, Tomita, Tadanori, James, C David, Shilatifard, Ali, Saratsis, Amanda M

“…Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise…”
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Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma by Chastkofsky, Michael I, Pituch, Katarzyna C, Katagi, Hiroaki, Zannikou, Markella, Ilut, Liliana, Xiao, Ting, Han, Yu, Sonabend, Adam M, Curiel, David T, Bonner, Erin R, Nazarian, Javad, Horbinski, Craig M, James, C David, Saratsis, Amanda M, Hashizume, Rintaro, Lesniak, Maciej S, Balyasnikova, Irina V

“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
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Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid by Saratsis, Amanda M, Yadavilli, Sridevi, Magge, Suresh, Rood, Brian R, Perez, Jennifer, Hill, D Ashley, Hwang, Eugene, Kilburn, Lindsay, Packer, Roger J, Nazarian, Javad

“…Diffuse intrinsic pontine glioma (DIPG) is a leading cause of brain tumor-related death in children. DIPG is not surgically resectable, resulting in a paucity…”
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Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells by Huang, Tina Yi-Ting, Piunti, Andrea, Qi, Jin, Morgan, Marc, Bartom, Elizabeth, Shilatifard, Ali, Saratsis, Amanda M

“…Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V),…”
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Choroidal artery embolization in the management of cerebrospinal fluid overproduction: case report and review of the literature by Li, Daphne, Shokuhfar, Tahaamin, Pantalone, Julia, Rothstein, Brian, Alden, Tord D, Shaibani, Ali, Saratsis, Amanda M

“…Diffuse villous hyperplasia of the choroid plexus (DVHCP) is a rare cause of communicating hydrocephalus. DVHCP may be diagnosed radiographically and through…”
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Ventricular Cerebrospinal Fluid Sampling in Pediatric Diffuse Midline Glioma Patients: Institutional Experience and Review of the Literature by Li, Daphne, Stellpflug, Wendy, Romanski, Kathy, Kilgallon, Maureen, Speck, Stacy, Saratsis, Amanda M.

“…Purpose: Increasing evidence suggests that circulating biomarkers may serve diagnostic and longitudinal monitoring purposes in pediatric neuro-oncology. Mutant…”
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H3K27M mutant glioma: Disease definition and biological underpinnings by Saratsis, Amanda M, Knowles, Truman, Petrovic, Antonela, Nazarian, Javad

“…High-grade glioma (HGG) is the most common cause of cancer death in children and the most common primary central nervous system tumor in adults. While…”
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H3 K27M-altered glioma and diffuse intrinsic pontine glioma: Semi-systematic review of treatment landscape and future directions by van den Bent, Martin, Saratsis, Amanda M, Geurts, Marjolein, Franceschi, Enrico

“…H3 K27M-mutant diffuse glioma is a recently identified brain tumor associated with poor prognosis. As of 2016, it is classified by the World Health…”
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Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes by Huang, Tina, Garcia, Roxanna, Qi, Jin, Lulla, Rishi, Horbinski, Craig, Behdad, Amir, Wadhwani, Nitin, Shilatifard, Ali, James, Charles, Saratsis, Amanda M

“…Pediatric diffuse midline glioma is a highly morbid glial neoplasm that may arise in the thalamus or brainstem (also known as diffuse intrinsic pontine glioma…”
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Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth by Hashizume, Rintaro, Zhang, Ali, Mueller, Sabine, Prados, Michael D, Lulla, Rishi R, Goldman, Stewart, Saratsis, Amanda M, Mazar, Andrew P, Stegh, Alexander H, Cheng, Shi-Yuan, Horbinski, Craig, Haas-Kogan, Daphne A, Sarkaria, Jann N, Waldman, Todd, James, C David

“…Radiation therapy is the most commonly used postsurgical treatment for primary malignant brain tumors. Consequently, investigating the efficacy of…”
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Gorham Stout disease of the temporal bone with cerebrospinal fluid leak by Aouad, Pascale, Young, Nancy M., Saratsis, Amanda M., Reynolds, Meredith A., Ryan, Maura E.

“…Gorham Stout disease (GSD) is a rare disease characterized by the proliferation of endothelial lined vessels and replacement of bone by fibrous tissue. The…”
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LIN28B and Let-7 in Diffuse Midline Glioma: A Review by Knowles, Truman, Huang, Tina, Qi, Jin, An, Shejuan, Burket, Noah, Cooper, Scott, Nazarian, Javad, Saratsis, Amanda M

“…Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. DMGs are driven by histone-tail-mutation-mediated epigenetic dysregulation and…”
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Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma by Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro

“…Abstract Background Diffuse intrinsic pontine glioma (DIPG) is associated with transcriptional dysregulation driven by H3K27 mutation. The super elongation…”
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Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes by Saratsis, Amanda M., Kambhampati, Madhuri, Snyder, Kendall, Yadavilli, Sridevi, Devaney, Joseph M., Harmon, Brennan, Hall, Jordan, Raabe, Eric H., An, Ping, Weingart, Melanie, Rood, Brian R., Magge, Suresh N., MacDonald, Tobey J., Packer, Roger J., Nazarian, Javad

“…Diffuse intrinsic pontine glioma (DIPG) is a highly morbid form of pediatric brainstem glioma. Here, we present the first comprehensive protein, mRNA, and…”
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Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma by An, Shejuan, Camarillo, Jeannie M, Huang, Tina Yi-Ting, Li, Daphne, Morris, Juliette A, Zoltek, Madeline A, Qi, Jin, Behbahani, Mandana, Kambhampati, Madhuri, Kelleher, Neil L, Nazarian, Javad, Thomas, Paul M, Saratsis, Amanda M

“…Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor. Most DIPGs harbor a histone H3 mutation, which alters histone…”
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Safety of Ventricular Reservoir Sampling in Pediatric Posthemorrhagic Hydrocephalus Patients: Institutional Experience and Review of the Literature by Li, Daphne, Romanski, Kathy, Kilgallon, Maureen, Speck, Stacy, Bowman, Robin, DiPatri, Arthur, Alden, Tord, Tomita, Tadanori, Lam, Sandi, Saratsis, Amanda M.

“…INTRODUCTION: Posthemorrhagic hydrocephalus (PHH) is a common disease process encountered in neonates. Management often includes cerebrospinal fluid (CSF)…”
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Correction to: Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes by Saratsis, Amanda M., Kambhampati, Madhuri, Snyder, Kendall, Yadavilli, Sridevi, Devaney, Joseph M., Harmon, Brennan, Hall, Jordan, Raabe, Eric H., An, Ping, Weingart, Melanie, Rood, Brian R., Magge, Suresh N., MacDonald, Tobey J., Packer, Roger J., Nazarian, Javad

“…The original version of this article unfortunately contained a mistake…”
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