Search Results - "Sarafanov, Andrey G."

Plasma Clearance of Coagulation Factor VIII and Extension of Its Half-Life for the Therapy of Hemophilia A: A Critical Review of the Current State of Research and Practice by Sarafanov, Andrey G

“…Factor VIII (FVIII) is an important component of blood coagulation as its congenital deficiency results in life-threatening bleeding. Current prophylactic…”
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Isolated Variable Domains of an Antibody Can Assemble on Blood Coagulation Factor VIII into a Functional Fv-like Complex by Shestopal, Svetlana A., Parunov, Leonid A., Olivares, Philip, Chun, Haarin, Ovanesov, Mikhail V., Pettersson, John R., Sarafanov, Andrey G.

“…Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (VL and VH) are connected via an…”
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Cluster III of Low-Density Lipoprotein Receptor-Related Protein 1 Binds Activated Blood Coagulation Factor VIII by Kurasawa, James H, Shestopal, Svetlana A, Woodle, Samuel A, Ovanesov, Mikhail V, Lee, Timothy K, Sarafanov, Andrey G

“…Low-density lipoprotein receptor-related protein 1 (LRP) mediates clearance of blood coagulation factor VIII (FVIII). In LRP, FVIII binds the complement-type…”
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Mapping the Binding Region on the Low Density Lipoprotein Receptor for Blood Coagulation Factor VIII by Kurasawa, James H., Shestopal, Svetlana A., Karnaukhova, Elena, Struble, Evi B., Lee, Timothy K., Sarafanov, Andrey G.

“…Low density lipoprotein receptor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulation. To elucidate the…”
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Analysis of iron, zinc, selenium and cadmium in paraffin-embedded prostate tissue specimens using inductively coupled plasma mass-spectrometry by Sarafanov, Andrey G., Todorov, Todor I., Kajdacsy-Balla, André, Gray, Marion A., Macias, Virgilia, Centeno, José A.

“…Formalin-fixed paraffin-embedded (FFPE) tissue specimens represent a valuable and abundant resource of pathologic material for various biomedical studies. In…”
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Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors by Marakasova, Ekaterina, Olivares, Philip, Karnaukhova, Elena, Chun, Haarin, Hernandez, Nancy E., Kurasawa, James H., Hassink, Gabriela U., Shestopal, Svetlana A., Strickland, Dudley K., Sarafanov, Andrey G.

“…The low-density lipoprotein receptor (LDLR) family of receptors are cell-surface receptors that internalize numerous ligands and play crucial role in various…”
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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts by Chun, Haarin, Kurasawa, James H., Olivares, Philip, Marakasova, Ekaterina S., Shestopal, Svetlana A., Hassink, Gabriela U., Karnaukhova, Elena, Migliorini, Mary, Obi, Juliet O., Smith, Ally K., Wintrode, Patrick L., Durai, Prasannavenkatesh, Park, Keunwan, Deredge, Daniel, Strickland, Dudley K., Sarafanov, Andrey G.

“…Deficiency in blood coagulation factor VIII (FVIII) results in life‐threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve…”
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Characterization of protein unable to bind von Willebrand factor in recombinant factor VIII products by Chun, Haarin, Pettersson, John R., Shestopal, Svetlana A., Wu, Wells W., Marakasova, Ekaterina S., Olivares, Philip, Surov, Stepan S., Ovanesov, Mikhail V., Shen, Rong‐Fong, Sarafanov, Andrey G.

“…Background Therapeutic products with coagulation factor VIII (FVIII) have a wide range of specific activities, implying presence of protein with altered…”
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Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII by Sarafanov, Andrey G, Makogonenko, Evgeny M, Andersen, Olav M, Mikhailenko, Irina A, Ananyeva, Natalya M, Khrenov, Alexey V, Shima, Midori, Strickland, Dudley K, Saenko, Evgueni L

“…Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed…”
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Hysteresis-like binding of coagulation factors X/Xa to procoagulant activated platelets and phospholipids results from multistep association and membrane-dependent multimerization by Podoplelova, Nadezhda A., Sveshnikova, Anastasia N., Kurasawa, James H., Sarafanov, Andrey G., Chambost, Herve, Vasil'ev, Sergey A., Demina, Irina A., Ataullakhanov, Fazly I., Alessi, Marie-Christine, Panteleev, Mikhail A.

“…Binding of coagulation factors X (fX) and Xa (fXa) to activated platelets is required for the formation of membrane-dependent enzymatic complexes of intrinsic…”
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Prostate cancer outcome and tissue levels of metal ions by Sarafanov, Andrey G., Todorov, Todor I., Centeno, José A., Macias, Virgilia, Gao, Weihua, Liang, Wei-Min, Beam, Craig, Gray, Marion A., Kajdacsy-Balla, André A.

“…BACKGROUND There are several studies examining prostate cancer and exposure to cadmium, iron, selenium, and zinc. Less data are available on the possible…”
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Insect cell-based expression and characterization of a single-chain variable antibody fragment directed against blood coagulation factor VIII by Kurasawa, James H., Shestopal, Svetlana A., Jha, Naveen K., Ovanesov, Mikhail V., Lee, Timothy K., Sarafanov, Andrey G.

“…A recombinant single-chain variable antibody fragment (scFv) KM33 was previously described as a ligand that can inhibit the function of blood coagulation…”
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Identification of Coagulation Factor VIII A2 Domain Residues Forming the Binding Epitope for Low-Density Lipoprotein Receptor-Related Protein by Sarafanov, Andrey G, Makogonenko, Evgeny M, Pechik, Igor V, Radtke, Klaus-Peter, Khrenov, Alexey V, Ananyeva, Natalya M, Strickland, Dudley K, Saenko, Evgueni L

“…Regulation of the coagulation factor VIII (fVIII) level in circulation involves a hepatic receptor low-density lipoprotein receptor-related protein (LRP). One…”
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Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484–509 by Ananyeva, Natalya M, Makogonenko, Yevgen M, Sarafanov, Andrey G, Pechik, Igor V, Gorlatova, Natalya, Radtke, Klaus P, Shima, Midori, Saenko, Evgueni L

“…Coagulation factor VIII interacts with several members of the low-density lipoprotein receptor family including low-density lipoprotein receptor-related…”
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Role of Activation of the Coagulation Factor VIII in Interaction with vWf, Phospholipid, and Functioning within the Factor Xase Complex by Saenko, Evgueni L, Shima, Midori, Sarafanov, Andrey G

“…Blood coagulation factor VIII (fVIII) in its nonactivated form circulates in plasma in a complex with von Willebrand factor (vWf). Upon activation by thrombin-…”
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Characterization of Interaction of Factor VIII with Engineered Variants of a Single-Chain Variable Antibody Fragment by Shestopal, Svetlana A, Parunov, Leonid A, Ovanesov, Mikhail V, Lee, Timothy K, Sarafanov, Andrey G

“…Introduction Replacement therapy for Hemophilia A requires frequent infusions of Factor VIII (FVIII) due to its relatively short half-life of ~12 h in plasma…”
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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts by Chun, Haarin, Kurasawa, James H., Olivares, Philip, Marakasova, Ekaterina S., Shestopal, Svetlana A., Hassink, Gabriela U., Karnaukhova, Elena, Migliorini, Mary, Obi, Juliet O., Smith, Ally K., Wintrode, Patrick L., Durai, Prasannavenkatesh, Park, Keunwan, Deredge, Daniel, Strickland, Dudley K., Sarafanov, Andrey G.

“…Not provided…”
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Von Willebrand Factor A1 Domain Binds to Clusters II and IV of Low-Density Lipoprotein Receptor-Related Protein 1 by Uceda Cortez, Gabriela, Shestopal, Svetlana A, Kurasawa, James H, Lee, Timothy K, Sarafanov, Andrey G

“…Introduction. Von Willebrand factor (VWF) is a large multimeric plasma glycoprotein involved in hemostasis and thrombosis. Genetic and in vivo studies have…”
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Characterization of Protein Unable to Bind Von Willebrand Factor in Recombinant Factor VIII Products: Can We Reduce Their Immunogenicity? by Chun, Haarin, Pettersson, John R, Shestopal, Svetlana A, Wu, Wells W, Marakasova, Ekaterina S, Olivares, Philip, Surov, Stepan S, Ovanesov, Mikhail V, Shen, Rong-Fong, Lee, Timothy K, Sarafanov, Andrey G

“…Introduction Therapeutic products with blood coagulation factor VIII (FVIII) have a wide range of protein contents per activity unit (or IU/mg, specific…”
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Structural and Functional Characterization of a Codon Optimized Coagulation Factor VIII by Shestopal, Svetlana A, Kurasawa, James H, Hao, Jian-Jiang, Karnaukhova, Elena, Liang, Yideng, Lin, Min, Ovanesov, Mikhail V, Lee, Timothy K, McVey, John H, Sarafanov, Andrey G

“…Background. Production of recombinant factor VIII (FVIII) is challenging due to its low expression. Previously, it was shown that codon optimization of a B…”
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