CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome

CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome

The aim of this study is to investigate the frequency of allelic variants, associated with poor response to clopidogrel, and , associated with excessive response to clopidogrel, in patients with acute coronary syndrome (ACS) from Siberia and Moscow regions of Russia. The study included 512 ACS patie...

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Published in:Pharmacogenomics and personalized medicine Vol. 10; pp. 107 - 114
Main Authors: Mirzaev, Karin B, Zelenskaya, Elena M, Barbarash, Olga L, Ganyukov, Vladimir I, Apartsin, Konstantin A, Saraeva, Natalya O, Nikolaev, Konstantin Y, Ryzhikova, Kristina A, Lifshits, Galina I, Sychev, Dmitry A
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2017
Taylor & Francis Ltd
Dove Medical Press
Subjects:
Acute coronary syndrome
Acute coronary syndromes
Biology
Cardiology
Cardiovascular disease
Care and treatment
clopidogrel
CYP2C19
Cytochrome
Cytochrome P-450
Deoxyribonucleic acid
Development and progression
DNA
Drug dosages
Enzymes
ethnic differences
Genes
Genetic aspects
Genetic polymorphisms
Health aspects
Hospitals
Laboratories
Metabolism
Original Research
pharmacogenomics
Polymorphism
Population
Preventive medicine
Professional education
Research centers
Thrombosis
Russia
Siberia
dual antiplatelet therapy
clopidogrel resistance
P2Y12 receptor inhibitors
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Summary:The aim of this study is to investigate the frequency of allelic variants, associated with poor response to clopidogrel, and , associated with excessive response to clopidogrel, in patients with acute coronary syndrome (ACS) from Siberia and Moscow regions of Russia. The study included 512 ACS patients who were subsequently treated with coronary arterial stenting. The subjects assigned were from the cities of Central (Novosibirsk, Kemerovo), Eastern (Irkutsk), Northern (Surgut) Siberia regions and from Moscow region. The mean age of patients enrolled was 63.9±10.9 years. Among the assigned subjects, the proportion of men accounted for 80% and women 20%. According to the results obtained in the present study, from 16% up to 27.5% of patients in different regions of Russia have at least one "poor metabolizer" (PM) allele variant affecting clopidogrel metabolism and, therefore, suppressing its antiplatelet activity. allele variant was identified with the frequency of 15.4% up to 33.3%. The study revealed the presence of statistically significant differences in allele frequency between the Russian ethnic group patients from Eastern and Central Siberia ( =0.001; odds ratio=1.05 [95% confidence interval 1.01-1.09]). The study revealed statistically significant differences between the allele frequencies in Eastern and Central Siberia, which can probably be caused by a considerable number of Buryats inhabiting Eastern Siberia.
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ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S126305