Search Results - "Sar, Astrid M."

Towards a new combination therapy for tuberculosis with next generation benzothiazinones by Makarov, Vadim, Lechartier, Benoit, Zhang, Ming, Neres, João, van der Sar, Astrid M, Raadsen, Susanne A, Hartkoorn, Ruben C, Ryabova, Olga B, Vocat, Anthony, Decosterd, Laurent A, Widmer, Nicolas, Buclin, Thierry, Bitter, Wilbert, Andries, Koen, Pojer, Florence, Dyson, Paul J, Cole, Stewart T

“…The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo‐enzyme DprE1, decaprenylphosphoryl‐beta‐D‐ribose…”
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First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio) by Yoon, Sohye, Mitra, Suman, Wyse, Cathy, Alnabulsi, Ayham, Zou, Jun, Weerdenburg, Eveline M, van der Sar, Astrid M, Wang, Difei, Secombes, Christopher J, Bird, Steve

“…Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and…”
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Mycobacteria employ two different mechanisms to cross the blood–brain barrier by Leeuwen, Lisanne M., Boot, Maikel, Kuijl, Coen, Picavet, Daisy I., Stempvoort, Gunny, Pol, Susanne M.A., Vries, Helga E., Wel, Nicole N., Kuip, Martijn, Furth, A. Marceline, Sar, Astrid M., Bitter, Wilbert

“…Central nervous system (CNS) infection by Mycobacterium tuberculosis is one of the most devastating complications of tuberculosis, in particular in early…”
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CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity by Majolée, Jisca, Pronk, Manon C. A., Jim, Kin K., van Bezu, Jan S. M., van der Sar, Astrid M., Hordijk, Peter L., Kovačević, Igor

“…RhoGTPases regulate cytoskeletal dynamics, migration and cell-cell adhesion in endothelial cells. Besides regulation at the level of guanine nucleotide…”
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Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer Cells by Belo, Ana I, van der Sar, Astrid M, Tefsen, Boris, van Die, Irma

“…Galectin-4 (Gal-4) is a member of the galectin family of glycan binding proteins that shows a significantly higher expression in cystic tumors of the human…”
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Analysis of SecA2‐dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector by Woude, Aniek D., Stoop, Esther J. M., Stiess, Michael, Wang, Sen, Ummels, Roy, Stempvoort, Gunny, Piersma, Sander R., Cascioferro, Alessandro, Jiménez, Connie R., Houben, Edith N. G., Luirink, Joen, Pieters, Jean, Sar, Astrid M., Bitter, Wilbert

“…Summary The pathogenicity of mycobacteria is closely associated with their ability to export virulence factors. For this purpose, mycobacteria possess…”
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MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model by Sar, Astrid M. van der, Stockhammer, Oliver W, Laan, Carina van der, Spaink, Herman P, Bitter, Wilbert, Meijer, Annemarie H

“…Innate immunity signaling mechanisms during vertebrate embryogenesis are largely unknown. To study Toll-like receptor (TLR) signaling function in the zebrafish…”
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Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity by Stoop, Esther J. M., Mishra, Arun K., Driessen, Nicole N., Stempvoort, Gunny, Bouchier, Pascale, Verboom, Theo, Leeuwen, Lisanne M., Sparrius, Marion, Raadsen, Susanne A., Zon, Maaike, Wel, Nicole N., Besra, Gurdyal S., Geurtsen, Jeroen, Bitter, Wilbert, Appelmelk, Ben J., Sar, Astrid M.

“…Summary The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, remains an important worldwide health threat. Although TB is one of the oldest…”
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Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development by Van Wijk, Rob C., Sar, Astrid M., Krekels, Elke H.J., Verboom, Theo, Spaink, Herman P., Simonsson, Ulrika S.H., Graaf, Piet H.

“…The zebrafish infected with Mycobacterium marinum (M. marinum) is an attractive tuberculosis disease model, showing similar pathogenesis to Mycobacterium…”
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The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection by Torraca, Vincenzo, Cui, Chao, Boland, Ralf, Bebelman, Jan-Paul, van der Sar, Astrid M, Smit, Martine J, Siderius, Marco, Spaink, Herman P, Meijer, Annemarie H

“…The recruitment of leukocytes to infectious foci depends strongly on the local release of chemoattractant mediators. The human CXC chemokine receptor 3 (CXCR3)…”
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EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF by Phan, Trang H, van Leeuwen, Lisanne M, Kuijl, Coen, Ummels, Roy, van Stempvoort, Gunny, Rubio-Canalejas, Alba, Piersma, Sander R, Jiménez, Connie R, van der Sar, Astrid M, Houben, Edith N G, Bitter, Wilbert

“…The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of…”
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Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry by Bruinen, Anne L., Fisher, Gregory L., Balez, Rachelle, van der Sar, Astrid M., Ooi, Lezanne, Heeren, Ron M. A.

“…A unique method for identification of biomolecular components in different biological specimens, while preserving the capability for high speed 2D and 3D…”
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Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease by Burggraaf, Maroeska J, Speer, Alexander, Meijers, Aniek S, Ummels, Roy, van der Sar, Astrid M, Korotkov, Konstantin V, Bitter, Wilbert, Kuijl, Coenraad

“…Tuberculosis, one of the world's most severe infectious diseases, is caused by A major weapon of this pathogen is a unique cell wall that protects the pathogen…”
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Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model by Jim, Kin Ki, Engelen-Lee, JooYeon, van der Sar, Astrid M, Bitter, Wilbert, Brouwer, Matthijs C, van der Ende, Arie, Veening, Jan-Willem, van de Beek, Diederik, Vandenbroucke-Grauls, Christina M J E

“…Streptococcus pneumoniae is one of the most important causes of bacterial meningitis, an infection where unfavourable outcome is driven by bacterial and…”
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Structure and Function of RNase AS, a Polyadenylate-Specific Exoribonuclease Affecting Mycobacterial Virulence In Vivo by Romano, Maria, van de Weerd, Robert, Brouwer, Femke C.C., Roviello, Giovanni N., Lacroix, Ruben, Sparrius, Marion, van den Brink-van Stempvoort, Gunny, Maaskant, Janneke J., van der Sar, Astrid M., Appelmelk, Ben J., Geurtsen, Jeroen J., Berisio, Rita

“…The cell-envelope of Mycobacterium tuberculosis plays a key role in bacterial virulence and antibiotic resistance. Little is known about the molecular…”
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Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components by van der Sar, Astrid M., Spaink, Herman P., Zakrzewska, Anna, Bitter, Wilbert, Meijer, Annemarie H.

“…Pathogenic mycobacteria have the ability to survive within macrophages and persist inside granulomas. The complex host–pathogen interactions that determine the…”
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The role of gamma interferon in innate immunity in the zebrafish embryo by Sieger, Dirk, Stein, Cornelia, Neifer, David, van der Sar, Astrid M, Leptin, Maria

“…The zebrafish genome contains ten genes that encode class II cytokine-like peptides, of which the two that are related most closely to mammalian interferon…”
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Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component by Stoop, Esther J M, Schipper, Tim, Rosendahl Huber, Sietske K, Nezhinsky, Alexander E, Verbeek, Fons J, Gurcha, Sudagar S, Besra, Gurdyal S, Vandenbroucke-Grauls, Christina M J E, Bitter, Wilbert, van der Sar, Astrid M

“…The hallmark of tuberculosis (TB) is the formation of granulomas, which are clusters of infected macrophages surrounded by additional macrophages, neutrophils…”
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Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum by van Leeuwen, Lisanne M, van der Kuip, Martijn, Youssef, Sameh A, de Bruin, Alain, Bitter, Wilbert, van Furth, A Marceline, van der Sar, Astrid M

“…Tuberculous meningitis (TBM) is one of the most severe extrapulmonary manifestations of tuberculosis, with a high morbidity and mortality. Characteristic…”
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Correction: First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio) by Yoon, Sohye, Mitra, Suman, Wyse, Cathy, Alnabulsi, Ayham, Zou, Jun, Weerdenburg, Eveline M, van der Sar, Astrid M, Wang, Difei, Secombes, Christopher J, Bird, Steve

“…[This corrects the article DOI: 10.1371/journal.pone.0126378.]…”
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