Huntington's Disease-Related Mortality Patterns: A Two-Decade Analysis of Mortality Trends in the United States, from 1999-2019

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder debilitating mainly in adults. This study aimed to assess the trends in HD-related mortality regarding various demographic factors. Death certificates from the CDC WONDER were studied from 1999 to 2019, f...

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Bibliographic Details
Published in:	Journal of Huntington's disease Vol. 13; no. 3; p. 329
Main Authors:	Bin Kashif, Muhammad Arham, Mahmood, Samar, Saqib, Tahrim, Waheed, Syeda Tahira, Kumar, Piresh, Javaid, Aima, Riaz, Muhammad Asjad, Fatima, Urooj, Nadeem, Zain Ali, Nasir, Shahbaz Ali, Hassan, Afrah
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2024
Subjects:	Adult Aged Aged, 80 and over Female Humans Huntington Disease - mortality Male Middle Aged Mortality - trends United States - epidemiology United States neurodegenerative CDC WONDER database Huntington’s disease autosomal dominant United States Mortality trends
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Summary:	Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder debilitating mainly in adults. This study aimed to assess the trends in HD-related mortality regarding various demographic factors. Death certificates from the CDC WONDER were studied from 1999 to 2019, for HD-related mortality in adults aged 25 + years. Age-adjusted Mortality Rate (AAMR) per 100,000 persons and Annual Percentage Change (APC) were calculated and stratified by year, age groups, gender, race/ethnicity, state, census region, urbanization, and place of death. Between 1999 to 2019, 22,595 deaths occurred in adults due to HD. The AAMR increased from 0.43 to 0.54 during this period (APC = 0.50; 95% CI: 0.18 to 0.84). Old adults (65-85 + years) had the highest overall AAMR, followed by middle-aged adults (45-64 years) and young adults (25-44 years) (AAMR old: 1.01 vs. AAMR middle-age: 0.68 vs. AAMR young: 0.16). Men had slightly greater overall AAMRs than women (AAMR men: 0.54 vs. AAMR women: 0.48). When stratified by race, non-Hispanic (NH) Whites had significantly higher mortality rates than NH African Americans (AAMR NH White: 0.61 vs. NH African American: 0.35), while the AAMR were lowest in Hispanic/Latino (0.28). The AAMRs also showed variation by region (overall AAMR: Midwest: 0.63, Northeast: 0.47, West: 0.48, South: 0.46), and non-metropolitan areas had higher HD-related AAMR (0.66) than metropolitan areas (0.47). HD-related mortality in US adults has increased since 1999. Reflecting on the variations in trends observed, new strategies are required to optimize the quality of care in long-term care facilities.
ISSN:	1879-6400
DOI:	10.3233/JHD-240037