Search Results - "Sapuru, Vinay"
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1
Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor
Published in Nature communications (28-10-2023)“…Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are endoplasmic reticulum Ca 2+ channels whose biphasic dependence on cytosolic Ca 2+ gives rise to Ca 2+…”
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2
Membrane-mediated protein interactions drive membrane protein organization
Published in Nature communications (30-11-2022)“…The plasma membrane’s main constituents, i.e., phospholipids and membrane proteins, are known to be organized in lipid-protein functional domains and…”
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3
Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175
Published in Journal of the American Chemical Society (21-08-2024)“…TMEM175 is a lysosomal potassium and proton channel that is associated with the development of Parkinson’s disease. Advances in understanding the physiological…”
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4
Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor
Published in Nature communications (28-10-2023)“…Inositol 1,4,5-trisphosphate receptors (IP Rs) are endoplasmic reticulum Ca channels whose biphasic dependence on cytosolic Ca gives rise to Ca oscillations…”
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Journal Article -
5
A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease
Published in Science advances (13-09-2024)“…Inositol 1,4,5-trisphosphate (IP3) receptor type 1 ( ), ( ), and ( ) encode the IP3 receptor (IP3R), a key player in intracellular calcium release. In four…”
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