Search Results - "Sappino, A. P."

ATM gene and lymphoid malignancies by GUMY-PAUSE, F, WACKER, P, SAPPINO, A-P

“…Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with…”
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Socio-demographic predictors of high support needs in newly diagnosed breast cancer patients by GRIESSER, A.-C., VLASTOS, G., MOREL, L., BEAUME, C., SAPPINO, A.-P., HALLER, G.

“…GRIESSER A.‐C., VLASTOS G., MOREL L., BEAUME C., SAPPINO A.‐P. & HALLER G. (2010) European Journal of Cancer Care
Socio‐demographic predictors of high support…”
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Recent increase of breast cancer incidence among women under the age of forty by BOUCHARDY, C, FIORETTA, G, CHAPPUIS, P, SAPPINO, A.-P, RAPITI, E, VERKOOIJEN, H. M, VLASTOS, G, SCHAEFER, P, DELALOYE, J.-F, NEYROUD-CASPAR, I, BALMER MAJNO, S, WESPI, Y, FORNI, M

“…Using data from the Geneva Cancer Registry, we found that in 2002-2004, breast cancer incidence in women aged 25-39 years increased by 46.7% per year (95% CI:…”
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Trend of burnout among Swiss doctors by Arigoni, F, Bovier, P A, Sappino, A P

“…Over the last decade the Swiss health care system has undergone several changes, resulting in stronger economic constraints, a heavier administrative workload…”
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Primary care physicians' knowledge and attitudes towards genetic testing for breast-ovarian cancer predisposition by Escher, M., Sappino, A.-P.

“…Background: Primary health care providers are expected to be directly involved in the genetic testing for cancer susceptibility. This study assessed…”
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A Simple p53 Functional Assay for Screening Cell Lines, Blood, and Tumors by J. -M. Flaman, Frebourg, T., Moreau, V., Charbonnier, F., Martin, C., Chappuis, P., A. -P. Sappino, J. -M. Limacher, Bron, L., Benhattar, J., Tada, M., Van Meir, E. G., Estreicher, A., Iggo, R. D.

“…Mutations in the p53 gene are implicated in the pathogenesis of half of all human tumors. We have developed a simple functional assay for p53 mutation in which…”
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Upregulation of Urokinase Receptor Expression on Migrating Endothelial Cells by Pepper, M. S., A.-P. Sappino, Stöcklin, R., Montesano, R., Orci, L., J.-D. Vassalli

“…One of the phenotypic hallmarks of migrating endothelial cells, both in vivo and in vitro, is expression of the urokinase-type plasminogen activator (u-PA), a…”
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Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study by VERKOOIJEN, H. M, CHAPPUIS, P. O, RAPITI, E, VLASTOS, G, FIORETTA, G, SARP, S, SAPPINO, A. P, SCHUBERT, H, BOUCHARDY, C

“…This population-based study evaluates the impact of a strong family history of breast cancer on management and survival of women with early-onset disease. We…”
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Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations by Sappino, A P, Schürch, W, Gabbiani, G

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ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia by Gumy-Pause, F, Wacker, P, Maillet, P, Betts, D R, Sappino, A-P

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The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage by Sappino, A-P, Buser, R, Seguin, Q, Fernet, M, Lesne, L, Gumy-Pause, F, Reith, W, Favaudon, V, Mandriota, S J

“…The p53 tumor-suppressor protein has a key role in the induction of cellular senescence, an important barrier to cancer development. However, very little is…”
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The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection by Kindler, V, Sappino, A P, Grau, G E, Piguet, P F, Vassalli, P

“…Granuloma formation in the liver of mice infected with BCG coincides with local TNF synthesis. Injection of rabbit anti-TNF antibody, after 1 or 2 weeks of…”
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The plasminogen activator/plasmin system by VASSALLI, J.-D, SAPPINO, A.-P, BELIN, D

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Plasminogen activation in synovial tissues: differences between normal, osteoarthritis, and rheumatoid arthritis joints by Busso, Nathalie, Péclat, Véronique, So, Alexander, Sappino, André-Pascal

“…OBJECTIVE To analyse the functional activity of the plasminogen activators urokinase (uPA) and tissue type plasminogen activator (tPA) in human synovial…”
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A polymorphism in the ATM gene modulates the penetrance of hereditary non‐polyposis colorectal cancer by Maillet, P., Chappuis, P.O., Vaudan, G., Dobbie, Z., Müller, H., Hutter, P., Sappino, A.‐P.

“…Germ‐line mutations in MLH1 and MSH2 genes predispose to hereditary non‐polyposis colorectal cancer (HNPCC) syndrome, but they do not predict a specific…”
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Set-up of a population-based familial breast cancer registry in Geneva, Switzerland: validation of first results by Verkooijen, H. M., Fioretta, G., Chappuis, P. O., Vlastos, G., Sappino, A. P., Benhamou, S., Bouchardy, C.

“…Background: This article evaluates the accuracy of family history of breast and ovarian cancer among first-degree relatives of breast cancer patients,…”
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Constitutional alterations of the ATM gene in early onset sporadic breast cancer by Maillet, P, Bonnefoi, H, Vaudan-Vutskits, G, Pajk, B, Cufer, T, Foulkes, W D, Chappuis, P O, Sappino, A-P

“…After initial denaturation at 94°C for five minutes, each of the 35 cycles of amplification consisted of 30 seconds at 94°C, 30 seconds at optimal annealing…”
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Malignant glioma: Should chemotherapy be overthrown by experimental treatments? by Hösli, P., Sappino, A. P., de Tribolet, N., Dietrich, P. Y.

“…Despite more than two decades of clinical research with chemotherapy, the outcome of malignant gliomas remains poor. Recent years have seen major advances in…”
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Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues by Sappino, A P, Skalli, O, Jackson, B, Schürch, W, Gabbiani, G

“…A mouse monoclonal antibody (MAb) recognizing alpha-smooth-muscle actin has been used to study smooth-muscle differentiation features in the stromal cells of…”
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Extracellular proteolysis in the adult murine brain by SAPPINO, A.-P, MADANI, R, HUARTE, J, BELIN, D, KISS, J. Z, WOHLWEND, A, VASSALLI, J.-D

“…Plasminogen activators are important mediators of extracellular metabolism. In the nervous system, plasminogen activators are thought to be involved in the…”
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