Search Results - "Sapp, D W"

The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol by Kokka, N, Sapp, D W, Taylor, A M, Olsen, R W

“…Rats on a chronic intermittent ethanol (CIE) regimen showed a persistent reduction in seizure threshold to the convulsant drug pentylenetetrazol (PTZ). CIE…”
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Identification of a Selective Inverse Agonist for the Orphan Nuclear Receptor Estrogen-Related Receptor α by Busch, Brett B, Stevens, William C, Martin, Richard, Ordentlich, Peter, Zhou, Sihong, Sapp, Douglas W, Horlick, Robert A, Mohan, Raju

“…The estrogen-related receptor α (ERRα) is an orphan receptor belonging to the nuclear receptor superfamily. The physiological role of ERRα has yet to be…”
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Human Striatal Dopamine Receptors are Organized in Compartments by Joyce, Jeffrey N., Sapp, Douglas W., Marshall, John F.

“…Dopamine (D2) receptors visualized in postmortem human striatum by quantitative autoradiography of [3H]spiroperidol binding are organized into circumscribed…”
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Regulation of PPARγ Coactivator 1α (PGC-1α) Signaling by an Estrogen-Related Receptor α (ERRα) Ligand by Willy, Patricia J., Murray, Ian R., Qian, Jing, Busch, Brett B., Stevens, William C., Martin, Richard, Mohan, Raju, Zhou, Sihong, Ordentlich, Peter, Wei, Ping, Sapp, Douglas W., Horlick, Robert A., Heyman, Richard A., Schulman, Ira G., Spiegelman, Bruce M.

“…Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a transcriptional coactivator that is a key component in the regulation of…”
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Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells by Rieff, H I, Raetzman, L T, Sapp, D W, Yeh, H H, Siegel, R E, Corfas, G

“…Neuregulin (NRG), a growth and differentiation factor that signals via erbB receptor tyrosine kinases, has been shown to have biological effects in both the…”
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Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates by Srinivasan, S, Sapp, D W, Tobin, A J, Olsen, R W

“…Neuroactive steroids and other positive modulators of GABA(A) receptors showed regional variation in both the efficacy and potency for modulation of [35S]TBPS…”
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The benzodiazepine/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepam by Turner, D M, Sapp, D W, Olsen, R W

“…The imidazobenzodiazepinone Ro 15-4513 has been shown previously to bind to central benzodiazepine receptors as well as to a second, uncharacterized class of…”
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Regional variation in steroid anesthetic modulation of [35S]TBPS binding to gamma-aminobutyric acidA receptors in rat brain by Sapp, D W, Witte, U, Turner, D M, Longoni, B, Kokka, N, Olsen, R W

“…Steroids that enhance gamma-aminobutyric acid (GABA)A receptor function in the central nervous system allosterically modulate the binding of the convulsant…”
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Persistent reduction of GABA A receptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment by Kang, Maenghee, Spigelman, Igor, Sapp, Douglas W., Olsen, Richard W.

“…GABA A receptor-mediated function was studied in rats treated with chronic intermittent ethanol (CIE). Rats were given 60 doses of 6 g/kg ethanol every 24 h by…”
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Age-related regional loss of caudate-putamen dopamine receptors revealed by quantitative autoradiography by Joyce, J N, Loeschen, S K, Sapp, D W, Marshall, J F

“…Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from…”
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Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding by Kokka, N, Sapp, D W, Witte, U, Olsen, R W

“…Female rats have a higher threshold than males for seizures induced by the convulsant pentylenetetrazol, a GABAA receptor-chloride channel complex blocker. No…”
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GABA alters GABAA receptor mRNAs and increases ligand binding by Kim, H Y, Sapp, D W, Olsen, R W, Tobin, A J

“…In addition to its role as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) influences the cytodifferentiation of developing neurons both in…”
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[3H]hemicholinium-3 binding in rabbit striatum: correspondence with patchy acetylcholinesterase staining and a method for quantifying striatal compartments by Rhodes, K J, Joyce, J N, Sapp, D W, Marshall, J F

“…Comparisons were made of the distribution of acetylcholinesterase (AChE) staining and [3H]hemicholinium-3 binding in adjacent tissue sections through the…”
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Neuroactive steroid modulation of GABAA receptors by Olsen, R W, Sapp, D W

“…In summary, the discovery of neuroactive steroids has led to a new appreciation of endocrine-nervous system interactions. The modulation of GABAA receptors by…”
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Persistent reduction of GABAA receptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment by KANG, M, SPIGELMAN, I, SAPP, D. W, OLSEN, R. W

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Altered GABAA Receptor Subunit and Splice Variant Expression in Rats Treated With Chronic Intermittent Ethanol by Petrie, Jennifer, Sapp, Douglas W., Tyndale, Rachel F., Park, Maenghee Kang, Fanselow, Michael, Olsen, Richard W.

“…Background: Intermittent chronic administration of ethanol to rats has been shown previously to produce a hyperexcitable, kindling‐like state, accompanied by…”
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Heterogeneity of GABA sub(A) Receptor-Mediated Responses in the Human IMR-32 Neuroblastoma Cell Line by Sapp, D W, Yeh, H H

“…The gamma -aminobutyric acid (GABA) response profiles of IMR-32 human neuroblastoma cells were examined using whole-cell patch clamp and RT-PCR techniques…”
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Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line by Sapp, D W, Yeh, H H

“…The gamma-aminobutyric acid (GABA) response profiles of IMR-32 human neuroblastoma cells were examined using whole-cell patch clamp and RT-PCR techniques. GABA…”
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Biphasic modulation of GABAA receptor binding by steroids suggests functional correlates by SRINIVASAN, S, SAPP, D. W, TOBIN, A. J, OLSEN, R. W

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Neuregulin Induces GABA sub(A) Receptor Subunit Expression and Neurite Outgrowth in Cerebellar Granule Cells by Rieff, H I, Raetzman, L T, Sapp, D W, Yeh, H H, Siegel, R E, Corfas, G

“…Neuregulin (NRG), a growth and differentiation factor that signals via erbB receptor tyrosine kinases, has been shown to have biological effects in both the…”
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