Search Results - "Sapozhnikov, Alexander M"

HSP70 Multi-Functionality in Cancer by Albakova, Zarema, Armeev, Grigoriy A, Kanevskiy, Leonid M, Kovalenko, Elena I, Sapozhnikov, Alexander M

“…The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic…”
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Extracellular heat shock proteins and cancer: New perspectives by Albakova, Zarema, Siam, Mohammad Kawsar Sharif, Sacitharan, Pradeep Kumar, Ziganshin, Rustam H., Ryazantsev, Dmitriy Y., Sapozhnikov, Alexander M.

“…•High expression of extracellular heat shock proteins (HSPs) indicates highly aggressive tumors.•HSP profiling of extracellular vesicles (EVs) derived from…”
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Analysis of NK cell clones obtained using interleukin-2 and gene-modified K562 cells revealed the ability of "senescent" NK cells to lose CD57 expression and start expressing NKG2A by Streltsova, Maria A, Erokhina, Sofya A, Kanevskiy, Leonid M, Lee, Dean A, Telford, William G, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…In this work, we analyzed the phenotype and growth of human NK cell clones obtained by the stimulation of individual NK cells with IL-2 and gene-modified K562…”
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The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors by Velichinskii, Rodion A, Streltsova, Maria A, Kust, Sofya A, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…NK cells are an attractive target for cancer immunotherapy due to their potent antitumor activity. The main advantage of using NK cells as cytotoxic effectors…”
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Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson's and Alzheimer's Diseases by Boyko, Anna A, Troyanova, Natalya I, Kovalenko, Elena I, Sapozhnikov, Alexander M

“…Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common age-related neurodegenerative disorders. Both diseases are characterized by chronic…”
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HLA-DR-Positive NK Cells Expand in Response to Mycobacterium Tuberculosis Antigens and Mediate Mycobacteria-Induced T Cell Activation by Kust, Sofya A, Streltsova, Maria A, Panteleev, Alexander V, Karpina, Natalya L, Lyadova, Irina V, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…NK cells play an important role in the control of tuberculosis infection: they are not only able to kill the infected cells, but also control the activity of…”
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Heat Shock Protein 70 kDa as a Target for Diagnostics and Therapy of Cardiovascular and Cerebrovascular Diseases by Konstantinova, Ekaterina V, Chipigina, Natalia S, Shurdumova, Marina H, Kovalenko, E I, Sapozhnikov, Alexander M

“…Acute focal ischemia is a main factor of pathogenesis of a number of widespread cardiovascular and cerebrovascular diseases, in particular, myocardial…”
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Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background by Vavilova, Julia D, Boyko, Anna A, Ponomareva, Natalya V, Fokin, Vitaly F, Fedotova, Ekaterina Y, Streltsova, Maria A, Kust, Sofya A, Grechikhina, Maria V, Bril, Ekaterina V, Zimnyakova, Olga S, Kovalenko, Elena I, Sapozhnikov, Alexander M

“…Immunosenescence is a process of remodeling the immune system under the influence of chronic inflammation during aging. Parkinson's disease (PD) is a common…”
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Coordinated Loss and Acquisition of NK Cell Surface Markers Accompanied by Generalized Cytokine Dysregulation in COVID-19 by Ustiuzhanina, Maria O, Vavilova, Julia D, Boyko, Anna A, Streltsova, Maria A, Kust, Sofya A, Kanevskiy, Leonid M, Sapozhnikov, Alexander M, Iskhakov, Rustam N, Gubernatorova, Ekaterina O, Drutskaya, Marina S, Bychinin, Mikhail V, Zhukova, Oksana A, Novikova, Oksana N, Sotnikova, Anna G, Yusubalieva, Gaukhar M, Baklaushev, Vladimir P, Kovalenko, Elena I

“…Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, is accompanied by a dysregulated immune response. In particular, NK cells, involved in the…”
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Short-Term Effect of SARS-CoV-2 Spike Protein Receptor-Binding Domain-Specific Antibody Induction on Neutrophil-Mediated Immune Response in Mice by Bolkhovitina, Elena L., Vavilova, Julia D., Bogorodskiy, Andrey O., Zagryadskaya, Yuliya A., Okhrimenko, Ivan S., Sapozhnikov, Alexander M., Borshchevskiy, Valentin I., Shevchenko, Marina A.

“…Vaccination protects against COVID-19 via the spike protein receptor-binding domain (RBD)-specific antibody formation, but it also affects the innate immunity…”
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Alterations in the CD56 - and CD56 + T Cell Subsets during COVID-19 by Vavilova, Julia D, Ustiuzhanina, Maria O, Boyko, Anna A, Streltsova, Maria A, Kust, Sofya A, Kanevskiy, Leonid M, Iskhakov, Rustam N, Sapozhnikov, Alexander M, Gubernatorova, Ekaterina O, Drutskaya, Marina S, Bychinin, Mikhail V, Novikova, Oksana N, Sotnikova, Anna G, Yusubalieva, Gaukhar M, Baklaushev, Vladimir P, Kovalenko, Elena I

“…The effectiveness of the antiviral immune response largely depends on the activation of cytotoxic T cells. The heterogeneous group of functionally active T…”
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Lipopolysaccharide induces IFN-γ production in human NK cells by Kanevskiy, Leonid M, Telford, William G, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…Natural killer (NK) cells have been shown to play a regulatory role in sepsis. According to the current view, NK cells become activated via macrophages or…”
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Increased Susceptibility of the CD57 - NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response by Palamarchuk, Anastasia I, Alekseeva, Nadezhda A, Streltsova, Maria A, Ustiuzhanina, Maria O, Kobyzeva, Polina A, Kust, Sofya A, Grechikhina, Maria V, Boyko, Anna A, Shustova, Olga A, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…Nowadays, the use of genetically modified NK cells is a promising strategy for cancer immunotherapy. The additional insertion of genes capable of inducing cell…”
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Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood by Kovalenko, Elena I, Zvyagin, Ivan V, Streltsova, Maria A, Mikelov, Artem I, Erokhina, Sofya A, Telford, William G, Sapozhnikov, Alexander M, Lebedev, Yury B

“…T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for…”
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Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations by Bogdanov, Ivan V, Streltsova, Maria A, Kovalenko, Elena I, Sapozhnikov, Alexander M, Panteleev, Pavel V, Ovchinnikova, Tatiana V

“…The only human cathelicidin, LL-37, is a host defense antimicrobial peptide with antimicrobial activities against protozoans, fungi, Gram(+) and Gram(−)…”
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Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and Lifespan by Streltsova, Maria A, Erokhina, Sofya A, Kanevskiy, Leonid M, Grechikhina, Maria V, Kobyzeva, Polina A, Lee, Dean A, Telford, William G, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…A pattern of natural killer cell (NK cell) heterogeneity determines proliferative and functional responses to activating stimuli in individuals. Obtaining the…”
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Three-Dimensional Model Analysis Revealed Differential Cytotoxic Effects of the NK-92 Cell Line and Primary NK Cells on Breast and Ovarian Carcinoma Cell Lines Mediated by Variations in Receptor-Ligand Interactions and Soluble Factor Profiles by Alekseeva, Nadezhda A, Boyko, Anna A, Shevchenko, Marina A, Grechikhina, Maria V, Streltsova, Maria A, Alekseeva, Ludmila G, Sapozhnikov, Alexander M, Deyev, Sergey M, Kovalenko, Elena I

“…The functional activity of a certain tumor determines the effectiveness of primary NK cells and NK-92 cell line-based cancer therapy; their therapeutic…”
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Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair by Alekseeva, Ludmila G, Ovsyanikova, Olga V, Schulga, Alexey A, Grechikhina, Maria V, Shustova, Olga A, Kovalenko, Elena I, Svirshchevskaya, Elena V, Deyev, Sergey M, Sapozhnikov, Alexander M

“…(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins…”
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The Role of O-Antigen in LPS-Induced Activation of Human NK Cells by Kovalenko, Elena I., Telford, William G., Ziganshin, Rustam H., Streltsova, Maria A., Erokhina, Sofya A., Kanevskiy, Leonid M., Sapozhnikov, Alexander M.

“…NK cells can be stimulated by bacterial lipopolysaccharides (LPS). Unlike macrophages, human NK cells do not express or express very low level of surface TLR4…”
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Barnase as a new therapeutic agent triggering apoptosis in human cancer cells by Edelweiss, Evelina, Balandin, Taras G, Ivanova, Julia L, Lutsenko, Gennady V, Leonova, Olga G, Popenko, Vladimir I, Sapozhnikov, Alexander M, Deyev, Sergey M

“…RNases are currently studied as non-mutagenic alternatives to the harmful DNA-damaging anticancer drugs commonly used in clinical practice. Many mammalian…”
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