Search Results - "Saporita, Anthony"

Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers by Zhang, Yandong, Baysac, Kathleen C, Yee, Lian-Fai, Saporita, Anthony J, Weber, Jason D

“…The DDX21 RNA helicase has been shown to be a nucleolar and nuclear protein involved in ribosome RNA processing and AP-1 transcription. DDX21 is highly…”
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ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis by Forys, Jason T., Kuzmicki, Catherine E., Saporita, Anthony J., Winkeler, Crystal L., Maggi, Leonard B., Weber, Jason D.

“…The ARF and p53 tumor suppressors are thought to act in a linear pathway to prevent cellular transformation in response to various oncogenic signals. Here, we…”
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The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells by Saporita, Anthony J., Ai, Junkui, Wang, Zhou

“…BACKGROUND Androgen receptor (AR) is the key molecule in androgen‐refractory prostate cancer. Despite androgen ablative conditions, AR remains active and is…”
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Hypergrowth mTORC1 Signals Translationally Activate the ARF Tumor Suppressor Checkpoint by Miceli, Alexander P., Saporita, Anthony J., Weber, Jason D.

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RNA Helicase DDX5 Is a p53-Independent Target of ARF That Participates in Ribosome Biogenesis by SAPORITA, Anthony J, CHANG, Hsiang-Chun, WINKELER, Crystal L, APICELLI, Anthony J, KLADNEY, Raleigh D, JIANBO WANG, REID TOWNSEND, R, MICHEL, Loren S, WEBER, Jason D

“…The p19ARF tumor suppressor limits ribosome biogenesis and responds to hyperproliferative signals to activate the p53 checkpoint response. Although its…”
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Identification and Characterization of a Ligand-regulated Nuclear Export Signal in Androgen Receptor by Saporita, Anthony J., Zhang, Qiuheng, Navai, Neema, Dincer, Zehra, Hahn, Junghyun, Cai, Xiaoyan, Wang, Zhou

“…Androgen receptor (AR) belongs to the steroid receptor superfamily that regulates gene expression in a ligand-dependent fashion. AR is localized to the…”
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p19ARF and RasV12 Offer Opposing Regulation of DHX33 Translation To Dictate Tumor Cell Fate by Zhang, Yandong, Saporita, Anthony J., Weber, Jason D.

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Therapeutic targets in the ARF tumor suppressor pathway by Saporita, Anthony J, Maggi, Jr, Leonard B, Apicelli, Anthony J, Weber, Jason D

“…One of the outstanding fundamental questions in cancer cell biology concerns how cells coordinate cellular growth (or macromolecular synthesis) with cell cycle…”
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Ranked abundance of 115 proteins following simultaneous measurement by multiplex immunoassay in serum, plasma, and cell culture supernatant samples by Droll, Deborah, Saporita, Anthony, Gilliam, Brooke, Grana, Paula, Qiang, Xiao

“…Abstract MILLIPLEX™ PLEXpedition, a customizable multiplex immunoassay kit, was developed to simultaneously screen up to 115 targets including cytokines,…”
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Webinar | Characterizing the maternal immune environment during pregnancy: Implications for autism spectrum disorders by Jones, Karen, Saporita, Anthony

“…Under normal conditions, the maternal immune system is uniquely regulated during pregnancy to maintain a pathogen-free, yet noninflammatory environment for the…”
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Abstract 1453: Specific detection of mutant Ras oncoproteins in cell and tissue lysates by multiplex immunoassay by Hwang, Joseph B., Saporita, Anthony, Xiao, Qiang

“…Abstract Ras proteins (HRAS, KRAS, and NRAS) are small GTPases that function as molecular switches by alternating between inactive GDP-bound and active…”
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A Non-Tumor Suppressor Role for Basal p19ARF in Maintaining Nucleolar Structure and Function by Apicelli, Anthony J., Maggi, Leonard B., Hirbe, Angela C., Miceli, Alexander P., Olanich, Mary E., Schulte-Winkeler, Crystal L., Saporita, Anthony J., Kuchenreuther, Michael, Sanchez, José, Weilbaecher, Katherine, Weber, Jason D.

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Analysis of Ras G12V/D Mutation on Downstream Pathways Using Multiplex Immunoassays by Hwang, Joseph, Saporita, Anthony, Xiao, Qiang

“…Ras proteins are members of small GTPases that function as molecular switches by alternating between inactive GDP‐bound and active GTP‐bound states. Active…”
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Establishing an immunological profile of 96 cytokines, chemokines, and growth factors in human biofluids via MILLIPLEX® multiplex immunoassay by Steiner, Harold L, Williams, Sasha, Banerjee, Munmun, Saporita, Anthony, Gilliam, Brooke, Qiang, Xiao

“…Abstract Multiplex immunoassays are well-established research tools enabling the simultaneous measurement of several proteins in biological samples. In the…”
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Characterization of cytokine measurement in human serum, plasma, urine, tears, milk, CSF, and saliva with a MILLIPLEX® multiplex immunoassay by Steiner, Harold L, Luo, Hong, Ahmed, Tanzir, Gilliam, Brooke, Saporita, Anthony J, Qiang, Xiao

“…Abstract Multiplex immunoassays are valuable research tools for studying circulating cytokines. Here we evaluate the ability of the MILLIPLEX® Human…”
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Abstract 5298: Multiplex immunoassay characterization of 48 cytokines, chemokines, and growth factors in colorectal cancer by Lie, Wen-Rong, Steiner, Harold, Williams, Sasha, Banerjee, Munmun, Saporita, Anthony, Gilliam, Brooke, Xiao, Qiang

“…Abstract Cytokines, chemokines, and growth factors are critical mediators of immune system function capable of signaling through autocrine, paracrine, and…”
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Abstract 4611: Interrogation of PI3K signaling via multiplex detection of differential phosphorylation of specific Akt isoforms by Saporita, Anthony J., Schluter, Melissa, MacIvor, Debra, Mistry, Jehangir, Hwang, Joseph

“…Abstract The serine/threonine protein kinase Akt is a key node in the PI3K pathway, one of the primary signaling cascades hyperactivated in human cancer…”
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Abstract 205: Analysis of resistance to RTK inhibitors using a novel RTK multiplex assay by Chen, Lu, Saporita, Anthony J., Lie, Wen-Rong, Maheshwari, Reeti, Schluter, Melissa, Mistry, Jehangir, Hwang, Joseph

“…Abstract A novel multiplex immunoassay was developed for examining acquired resistance to Receptor Tyrosine Kinase (RTK) inhibitors. RTKs are transmembrane…”
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PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor―Positive Breast Cancer by CROWDER, Robert J, PHOMMALY, Chanpheng, SNIDER, Jacqueline, DAVIES, Sherri R, OLSON, John A, WATSON, Mark A, SAPORITA, Anthony, WEBER, Jason D, ELLIS, Matthew J, YU TAO, HOOG, Jeremy, JINGQIN LUO, PEROU, Charles M, PARKER, Joel S, MILLER, Melinda A, HUNTSMAN, David G, LI LIN

“…Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between…”
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p19 ARF and Ras V12 Offer Opposing Regulation of DHX33 Translation To Dictate Tumor Cell Fate by Zhang, Yandong, Saporita, Anthony J., Weber, Jason D.

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