Search Results - "Sapir, Tamar"

Using multi-organ culture systems to study Parkinson’s disease by Reiner, Orly, Sapir, Tamar, Parichha, Arpan

“…In recent years, it has been revealed that Parkinson’s disease pathology may begin to manifest in the gastrointestinal track at a much earlier time point than…”
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Developmental activities of the complement pathway in migrating neurons by Gorelik, Anna, Sapir, Tamar, Haffner-Krausz, Rebecca, Olender, Tsviya, Woodruff, Trent M., Reiner, Orly

“…In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune…”
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S1219 A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With Inflammatory Bowel DiSease Therapy: Updates From the ASSIST Study by Axelrad, Jordan, Sapir, Tamar, Horst, Sara N., DeFelice, Kara, Afzali, Anita, Abdelrehem, Aya, Noyes, Abigail, Anderson, Chelsea, Long, Millie D., Cross, Raymond K.

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Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1) by Segal-Salto, Michal, Sapir, Tamar, Reiner, Orly

“…Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative…”
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Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex by Sapir, Tamar, Kshirsagar, Aditya, Gorelik, Anna, Olender, Tsviya, Porat, Ziv, Scheffer, Ingrid E., Goldstein, David B., Devinsky, Orrin, Reiner, Orly

“…HNRNPU encodes the heterogeneous nuclear ribonucleoprotein U, which participates in RNA splicing and chromatin organization. Microdeletions in the 1q44 locus…”
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Microtubule dynamics in neuronal morphogenesis by Sakakibara, Akira, Ando, Ryota, Sapir, Tamar, Tanaka, Teruyuki

“…Microtubules (MTs) are essential for neuronal morphogenesis in the developing brain. The MT cytoskeleton provides physical support to shape the fine structure…”
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The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells by Chan, Susana M, Sapir, Tamar, Park, Sung-Soo, Rual, Jean-François, Contreras-Galindo, Rafael, Reiner, Orly, Markovitz, David M

“…Human endogenous retroviruses are remnants of ancient germline infections that make up approximately 8% of the modern human genome. The HERV-K (HML-2) family…”
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Tau's role in the developing brain: implications for intellectual disability by SAPIR, Tamar, FROTSCHER, Michael, LEVY, Talia, MANDELKOW, Eva-Maria, REINED, Orly

“…Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the…”
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LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways by Kshirsagar, Aditya, Doroshev, Svetlana Maslov, Gorelik, Anna, Olender, Tsviya, Sapir, Tamar, Tsuboi, Daisuke, Rosenhek-Goldian, Irit, Malitsky, Sergey, Itkin, Maxim, Argoetti, Amir, Mandel-Gutfreund, Yael, Cohen, Sidney R., Hanna, Jacob H., Ulitsky, Igor, Kaibuchi, Kozo, Reiner, Orly

“…Lissencephaly-1 ( LIS1 ) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show…”
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Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases by Sapir, Tamar, Levy, Talia, Kozer, Noga, Shin, Irina, Zamor, Vanessa, Haffner-Krausz, Rebecca, McGlade, Jane C, Reiner, Orly

“…Abstract The evolutionarily conserved Notch pathway plays an important role in regulation of stem cell renewal and cell fate determination in numerous organs,…”
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Serping1/ C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner by Gorelik, Anna, Sapir, Tamar, Woodruff, Trent M, Reiner, Orly

“…Current knowledge regarding regulation of radial neuronal migration is mainly focused on intracellular molecules. Our unbiased screen aimed at identification…”
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Polarity Regulation in Migrating Neurons in the Cortex by Reiner, Orly, Sapir, Tamar

“…The formation of the cerebral cortex requires migration of billions of cells from their birth position to their final destination. A motile cell must have…”
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The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function by Sapir, Tamar, Segal, Michal, Grigoryan, Gayane, Hansson, Karin M, James, Peter, Segal, Menahem, Reiner, Orly

“…Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the…”
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Complement C3 Affects Rac1 Activity in the Developing Brain by Gorelik, Anna, Sapir, Tamar, Ben-Reuven, Lihi, Reiner, Orly

“…The complement system, which is part of the innate immune response system, has been recently shown to participate in multiple key processes in the developing…”
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Brain Organization and Human Diseases by Sapir, Tamar, Sela-Donenfeld, Dalit, Karlinski, Maayan, Reiner, Orly

“…The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for…”
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Accurate Balance of the Polarity Kinase MARK2/Par-1 Is Required for Proper Cortical Neuronal Migration by Sapir, Tamar, Sapoznik, Sivan, Levy, Talia, Finkelshtein, Danit, Shmueli, Anat, Timm, Thomas, Mandelkow, Eva-Maria, Reiner, Orly

“…Radial neuronal migration is key in structuring the layered cortex. Here we studied the role of MARK2/Par-1 in this process. The dual name stands for the…”
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Increased LIS1 expression affects human and mouse brain development by Lu, Xin-Yan, Horner, Michele, Day-Salvatore, Debra-Lynn, Sahoo, Trilochan, Withers, Marjorie A, Cheung, Sau Wai, Gunderson, Kevin L, Hunter, Jill V, Sapir, Tamar, Peiffer, Daniel A, Yanagawa, Yuchio, Reiner, Orly, Shchelochkov, Oleg A, Levy, Talia, Lupski, James R, Nezarati, Marjan M, Martinez, Salvador, Savage, Sarah K, Shinder, Vera, Harris, David J, Ann Shotts, Vern, Bi, Weimin, Amato, Stephen S, Beaudet, Arthur L, Zhang, Feng

“…James Lupski, Orly Reiner and colleagues report seven individuals with submicroscopic copy number gains in the 17p13.3 region, supported by additional studies…”
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Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex by Reiner, Orly, Sapir, Tamar, Gerlitz, Gabi

“…The nuclei of neuroepithelial cells move along the apicobasal axis in synchronization with their cell cycle status. This motility is known as interkinetic…”
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A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and Persistence With Inflammatory Bowel Disease Therapy (ASSIST Study): Protocol for a Randomized Controlled Trial by Axelrad, Jordan, Long, Millie, Horst, Sara, Afzali, Anita, Sapir, Tamar, Fajardo, Kristina, De Felice, Kara, Sandler, Robert, Cross, Raymond

“…Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract. Although adherence to IBD therapies is associated with…”
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Cell-Replacement Therapy for Diabetes: Generating Functional Insulin-Producing Tissue from Adult Human Liver Cells by Sapir, Tamar, Shternhall, Keren, Meivar-Levy, Irit, Blumenfeld, Tamar, Cohen, Hamutal, Skutelsky, Ehud, Eventov-Friedman, Smadar, Barshack, Iris, Goldberg, Iris, Pri-Chen, Sarah, Ben-Dor, Lya, Polak-Charcon, Sylvie, Karasik, Avraham, Shimon, Ilan, Mor, Eytan, Ferber, Sarah, Kahn, C. Ronald

“…Shortage in tissue availability from cadaver donors and the need for life-long immunosuppression severely restrict the large-scale application of…”
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