Search Results - "Sapay, Nicolas"

Atomistic Simulations of Pore Formation and Closure in Lipid Bilayers by Bennett, W. F. Drew, Sapay, Nicolas, Tieleman, D. Peter

“…Cellular membranes separate distinct aqueous compartments, but can be breached by transient hydrophilic pores. A large energetic cost prevents pore formation,…”
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Prediction of amphipathic in-plane membrane anchors in monotopic proteins using a SVM classifier by Sapay, Nicolas, Guermeur, Yann, Deléage, Gilbert

“…Membrane proteins are estimated to represent about 25% of open reading frames in fully sequenced genomes. However, the experimental study of proteins remains…”
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Molecular modeling of the interaction between heparan sulfate and cellular growth factors: Bringing pieces together by Sapay, Nicolas, Cabannes, Eric, Petitou, Maurice, Imberty, Anne

“…Heparan sulfate is a polysaccharide belonging to the glycaminoglycan family. It interacts with numerous proteins of the extracellular matrix, in particular…”
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Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region by Voegele, Alexis, Subrini, Orso, Sapay, Nicolas, Ladant, Daniel, Chenal, Alexandre

“…The adenylate cyclase toxin CyaA is involved in the early stages of infection by , the causative agent of whooping cough. CyaA intoxicates target cells by a…”
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NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus by Montserret, Roland, Saint, Nathalie, Vanbelle, Christophe, Salvay, Andrés Gerardo, Simorre, Jean-Pierre, Ebel, Christine, Sapay, Nicolas, Renisio, Jean-Guillaume, Böckmann, Anja, Steinmann, Eike, Pietschmann, Thomas, Dubuisson, Jean, Chipot, Christophe, Penin, François

“…The small membrane protein p7 of hepatitis C virus forms oligomers and exhibits ion channel activity essential for virus infectivity. These viroporin features…”
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Regulation of Cardiac ATP-sensitive Potassium Channel Surface Expression by Calcium/Calmodulin-dependent Protein Kinase II by Sierra, Ana, Zhu, Zhiyong, Sapay, Nicolas, Sharotri, Vikas, Kline, Crystal F., Luczak, Elizabeth D., Subbotina, Ekaterina, Sivaprasadarao, Asipu, Snyder, Peter M., Mohler, Peter J., Anderson, Mark E., Vivaudou, Michel, Zingman, Leonid V., Hodgson-Zingman, Denice M.

“…Cardiac ATP-sensitive potassium (KATP) channels are key sensors and effectors of the metabolic status of cardiomyocytes. Alteration in their expression impacts…”
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NMR Structure and Molecular Dynamics of the In-Plane Membrane Anchor of Nonstructural Protein 5A from Bovine Viral Diarrhea Virus by Sapay, Nicolas, Montserret, Roland, Chipot, Christophe, Brass, Volker, Moradpour, Darius, Deléage, Gilbert, Penin, François

“…Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a monotopic membrane protein anchored to the membrane by an N-terminal in-plane amphipathic α-helix…”
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Conserved Determinants for Membrane Association of Nonstructural Protein 5A from Hepatitis C Virus and Related Viruses by BRASS, Volker, PAL, Zsuzsanna, SAPAY, Nicolas, DELEAGE, Gilbert, BLUM, Hubert E, PENIN, Francois, MORADPOUR, Darius

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Conserved Determinants for Membrane Association of Nonstructural Protein 5A fromHepatitis C Virus and Related Viruses by Brass, Volker, Pal, Zsuzsanna, Sapay, Nicolas, Deléage, Gilbert, Blum, Hubert E., Penin, François, Moradpour, Darius

“…ABSTRACT Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal…”
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Chapter 4 Molecular Dynamics Simulation of Lipid–Protein Interactions by Sapay, Nicolas, Tieleman, D. Peter

“…Membrane proteins and membrane-active peptides are attractive targets for computer simulations, both because of their intrinsic importance and the difficulties…”
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Arginine Contributions to the Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region by Voegele, Alexis, Sapay, Nicolas, Ladant, Daniel, Chenal, Alexandre

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Combination of the CHARMM27 force field with united-atom lipid force fields by Sapay, Nicolas, Tieleman, D. Peter

“…Computer simulations offer a valuable way to study membrane systems, from simple lipid bilayers to large transmembrane protein complexes and lipid‐nucleic acid…”
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Membrane-active properties of arginines residues of an amphitropic peptide from the CyaA toxin translocation domain by Voegele, Alexis, Subrini, Orso, Sapay, Nicolas, Ladant, Daniel, Chenal, Alexandre

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Immune Profiling Demonstrates a Common Immune Signature of Delayed Acquired Immunodeficiency in Patients With Various Etiologies of Severe Injury by Venet, Fabienne, Textoris, Julien, Blein, Sophie, Rol, Mary-Luz, Bodinier, Maxime, Canard, Bertrand, Cortez, Pierre, Meunier, Boris, Tan, Lionel K., Tipple, Craig, Quemeneur, Laurence, Reynier, Frédéric, Leissner, Philippe, Védrine, Christophe, Bouffard, Yves, Delwarde, Benjamin, Martin, Olivier, Girardot, Thibaut, Truc, Cyrille, Griffiths, Andrew D., Moucadel, Virginie, Pachot, Alexandre, Monneret, Guillaume, Rimmelé, Thomas

“…The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described the overtime…”
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Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients by Bodinier, Maxime, Peronnet, Estelle, Llitjos, Jean-François, Kreitmann, Louis, Brengel-Pesce, Karen, Rimmelé, Thomas, Fleurie, Aurore, Textoris, Julien, Venet, Fabienne, Maucort-Boulch, Delphine, Monneret, Guillaume

“…The immune response of critically ill patients, such as those with sepsis, severe trauma, or major surgery, is heterogeneous and dynamic, but its…”
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Characterization of a Membrane-active Peptide from the Bordetella pertussis CyaA Toxin by Subrini, Orso, Sotomayor-Pérez, Ana-Cristina, Hessel, Audrey, Spiaczka-Karst, Johanna, Selwa, Edithe, Sapay, Nicolas, Veneziano, Rémi, Pansieri, Jonathan, Chopineau, Joel, Ladant, Daniel, Chenal, Alexandre

“…Bordetella pertussis, the pathogenic bacteria responsible for whooping cough, secretes several virulence factors, among which is the adenylate cyclase toxin…”
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Mapping of heparin/heparan sulfate binding sites on αvβ3 integrin by molecular docking by Ballut, Lionel, Sapay, Nicolas, Chautard, Émilie, Imberty, Anne, Ricard-Blum, Sylvie

“…Heparin/heparan sulfate interact with growth factors, chemokines, extracellular proteins, and receptors. Integrins are αβ heterodimers that serve as receptors…”
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Molecular Simulations of Lipid Flip-Flop in the Presence of Model Transmembrane Helices by Sapay, Nicolas, Bennett, W. F. Drew, Tieleman, D. Peter

“…The transport of lipids between membrane leaflets, also known as flip-flop, is a key process in regulating the lipid composition of biological membranes. It is…”
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A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score by Tremblay, Jan-Alexis, Peron, Florian, Kreitmann, Louis, Textoris, Julien, Brengel-Pesce, Karen, Lukaszewicz, Anne-Claire, Quemeneur, Laurence, Vedrine, Christophe, Tan, Lionel K., Venet, Fabienne, Rimmele, Thomas, Monneret, Guillaume

“…Background Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness,…”
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Rebuilding a macromolecular membrane complex at the atomic scale: Case of the Kir6.2 potassium channel coupled to the muscarinic acetylcholine receptor M2: Molecular Modeling of an Ion Channel-Coupled Receptor by Sapay, Nicolas, Estrada-Mondragon, Argel, Moreau, Christophe, Vivaudou, Michel, Crouzy, Serge

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