Search Results - "Saparbaev, M"

Predictive biomarkers for cancer therapy with PARP inhibitors by Michels, J, Vitale, I, Saparbaev, M, Castedo, M, Kroemer, G

“…Poly(ADP-ribose) polymerase (PARP) inhibitors have raised high expectations for the treatment of multiple malignancies. PARP inhibitors, which can be used as…”
Get full text

An Assay for the Activity of Base Excision Repair Enzymes in Cellular Extracts Using Fluorescent DNA Probes by Kladova, O. A., Iakovlev, D. A., Groisman, R., Ishchenko, A. A., Saparbaev, M. K., Fedorova, O. S., Kuznetsov, N. A.

“…Damaged DNA bases are removed by the base excision repair (BER) mechanism. This enzymatic process begins with the action of one of DNA glycosylases, which…”
Get full text

DNA repair and the origins of urinary oxidized 2′-deoxyribonucleosides by Evans, Mark D., Saparbaev, Murat, Cooke, Marcus S.

“…Monitoring oxidative stress in vivo is made easier by the ability to use samples obtained non-invasively, such as urine. The analysis of DNA oxidation, by…”
Get full text

Aberrant DNA glycosylase-initiated repair pathway of free radicals in-duced DNA damage: implications for age-related diseases and natural aging by Matkarimov, B. T., Saparbaev, M. K.

“…Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that…”
Get full text

Characterization of Aspergillus niger endo-1,4-β-glucanase ENG1 secreted from Saccharomyces cerevisiae using different expression vectors by Taipakova, S M, Smekenov, I T, Saparbaev, M K, Bissenbaev, A K

“…Heterologous expression of Aspergillus niger endo-1,4-β-glucanase (ENG1) in Saccharomyces cerevisiae was tested both with an episomal plasmid vector…”
Get full text

Excision of Hypoxanthine from DNA Containing dIMP Residues by the Escherichia coli, Yeast, Rat, and Human Alkylpurine DNA Glycosylases by Saparbaev, Murat, Laval, Jacques

“…The deamination of adenine residues in DNA generates hypoxanthine, which is mutagenic since it gives rise to an A·T to G·C transition. Hypoxanthine is removed…”
Get full text

Kinetic mechanism of human apurinic/apyrimidinic endonuclease action in nucleotide incision repair by Timofeyeva, N. A, Koval, V. V, Ishchenko, A. A, Saparbaev, M. K, Fedorova, O. S

“…Human major apurinic/apyrimidinic endonuclease (APE1) is a multifunctional enzyme that plays a central role in DNA repair through the base excision repair…”
Get full text

Alternative nucleotide incision repair pathway for oxidative DNA damage by Saparbaev, Murat K, Ischenko, Alexander A

“…The DNA glycosylase pathway, which requires the sequential action of two enzymes for the incision of DNA, presents a serious problem for the efficient repair…”
Get full text

Enzymology of the repair of free radicals-induced DNA damage by Gros, Laurent, Saparbaev, Murat K, Laval, Jacques

“…A number of intrinsic and extrinsic mutagens induce structural damage in cellular DNA. These DNA damages are cytotoxic, miscoding or both and are believed to…”
Get full text

Conformational Dynamics of Human AP Endonuclease in Base Excision and Nucleotide Incision Repair Pathways by Timofeyeva, N. A., Koval, V. V., Knorre, D. G., Zharkov, D. O., Saparbaev, M. K., Ishchenko, A. A., Fedorova, O. S.

“…APE1 is a multifunctional enzyme that plays a central role in base excision repair (BER) of DNA. APE1 is also involved in the alternative nucleotide incision…”
Get full text

Characterisation of new substrate specificities of Escherichia coli and Saccharomyces cerevisiae AP endonucleases by Ishchenko, Alexander A., Sanz, Guenhaël, Privezentzev, Cyril V., Maksimenko, Andrei V., Saparbaev, Murat

“…Despite the progress in understanding the base excision repair (BER) pathway it is still unclear why known mutants deficient in DNA glycosylases that remove…”
Get full text

Kinetic mechanism of the interaction of Saccharomyces cerevisiae AP-endonuclease 1 with DNA substrates by Dyakonova, E. S., Koval, V. V., Ishchenko, A. A., Saparbaev, M. K., Kaptein, R., Fedorova, O. S.

“…The apurinic/apyrimidinic endonuclease from Saccharomyces cerevisiae Apn1 is one of the key enzymes involved in base excision repair of DNA lesions. A major…”
Get full text

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway by Gros, Laurent, Ishchenko, Alexander A., Ide, Hiroshi, Elder, Rhoderick H., Saparbaev, Murat K.

“…In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase‐independent manner, providing the correct ends for DNA…”
Get full text

Initiation of 8-oxoguanine base excision repair within trinucleotide tandem repeats by Derevyanko, A. G., Endutkin, A. V., Ishchenko, A. A., Saparbaev, M. K., Zharkov, D. O.

“…Trinucleotide repeat expansion provides a molecular basis for several devastating neurodegenerative diseases. In particular, expansion of a CAG run in the…”
Get full text

Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells by Couvé-Privat, Sophie, Macé, Gaëtane, Rosselli, Filippo, Saparbaev, Murat K

“…Interstrand cross-link (ICL) is a covalent modification of both strands of DNA, which prevents DNA strand separation during transcription and replication. Upon…”
Get full text

Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae by Saparbaev, M, Prakash, L, Prakash, S

“…The RAD1 and RAD10 genes of Saccharomyces cerevisiae are required for nucleotide excision repair and they also act in mitotic recombination. The Rad1-Rad10…”
Get full text

Characterisation of the substrate specificity of homogeneous vaccinia virus uracil‐DNA glycosylase by Scaramozzino, Natale, Sanz, Guenhael, Crance, Jean Marc, Saparbaev, Murat, Drillien, Robert, Laval, Jacques, Kavli, Bodil, Garin, Daniel

“…The decision to stop smallpox vaccination and the loss of specific immunity in a large proportion of the population could jeopardise world health due to the…”
Get full text

Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues by Saparbaev, M, Mani, J C, Laval, J

“…In DNA, the deamination of dAMP generates 2'-deoxy-inosine 5'-monophosphate (dIMP). Hypoxanthine (HX) residues are mutagenic since they give rise to A.T-->G.C…”
Get full text

A molecular beacon assay for measuring base excision repair activities by Maksimenko, Andrei, Ishchenko, Alexander A, Sanz, Guenhaël, Laval, Jacques, Elder, Rhoderick H, Saparbaev, Murat K

“…The base excision repair (BER) pathway plays a key role in protecting the genome from endogenous DNA damage. Current methods to measure BER activities are…”
Get full text

Enzymology of the repair of etheno adducts in mammalian cells and in Escherichia coli by Saparbaev, M, Laval, J

“…Exocyclic adducts are generated in cellular DNA by reaction with epoxides that are formed metabolically from various industrial pollutants and by reaction with…”
Get more information