Search Results - "Saotome, Mika"

Biochemical characterization of the RNA-binding and RNA-DNA strand exchange activities of the human RAD52 protein by Tsuchiya, Ryohei, Saotome, Mika, Kinoshita, Chiaki, Kamoi, Kazuki, Kagawa, Wataru

“…RAD52 is a single-stranded DNA (ssDNA) binding protein that functions in the repair of DNA double-strand breaks (DSBs) by promoting the annealing of…”
Get full text

The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring by Kinoshita, Chiaki, Takizawa, Yoshimasa, Saotome, Mika, Ogino, Shun, Kurumizaka, Hitoshi, Kagawa, Wataru

“…The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily…”
Get full text

GATA3 Truncation Mutants Alter EMT Related Gene Expression via Partial Motif Recognition in Luminal Breast Cancer Cells by Saotome, Mika, Poduval, Deepak Balakrishnan, Nair, Renju, Cooper, Mikhala, Takaku, Motoki

“…GATA3 is known to be one of the most frequently mutated genes in breast cancer. More than 10% of breast tumors carry mutations in this gene. However, the…”
Get full text

Structure determination of the nucleosome core particle by selenium SAD phasing by Saotome, Mika, Horikoshi, Naoki, Urano, Kazuki, Kujirai, Tomoya, Yuzurihara, Hidetaka, Kurumizaka, Hitoshi, Kagawa, Wataru

“…The eukaryotic genome is compacted inside the nucleus of the cell in the form called chromatin. The fundamental unit of chromatin is the nucleosome, which…”
Get full text

Structural Basis of Homology-Directed DNA Repair Mediated by RAD52 by Saotome, Mika, Saito, Kengo, Yasuda, Takeshi, Ohtomo, Hideaki, Sugiyama, Shusei, Nishimura, Yoshifumi, Kurumizaka, Hitoshi, Kagawa, Wataru

“…RAD52 mediates homologous recombination by annealing cDNA strands. However, the detailed mechanism of DNA annealing promoted by RAD52 has remained elusive…”
Get full text

Improved Methods for Preparing the Telomere Tethering Complex Bqt1–Bqt2 for Structural Studies by Yuzurihara, Hidetaka, Aizawa, Yuuki, Saotome, Mika, Ichikawa, Yuichi, Yokoyama, Hiroshi, Chikashige, Yuji, Haraguchi, Tokuko, Hiraoka, Yasushi, Kurumizaka, Hitoshi, Kagawa, Wataru

“…In eukaryotes, chromosome ends (telomeres) are tethered to the inner nuclear membrane. During the early stages of meiosis, telomeres move along the nuclear…”
Get full text

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites by Yasuda, Takeshi, Kagawa, Wataru, Ogi, Tomoo, Kato, Takamitsu A, Suzuki, Takehiro, Dohmae, Naoshi, Takizawa, Kazuya, Nakazawa, Yuka, Genet, Matthew D, Saotome, Mika, Hama, Michio, Konishi, Teruaki, Nakajima, Nakako Izumi, Hazawa, Masaharu, Tomita, Masanori, Koike, Manabu, Noshiro, Katsuko, Tomiyama, Kenichi, Obara, Chizuka, Gotoh, Takaya, Ui, Ayako, Fujimori, Akira, Nakayama, Fumiaki, Hanaoka, Fumio, Sugasawa, Kaoru, Okayasu, Ryuichi, Jeggo, Penny A, Tajima, Katsushi

“…The p300 and CBP histone acetyltransferases are recruited to DNA double-strand break (DSB) sites where they induce histone acetylation, thereby influencing the…”
Get full text

Structure of the human DNA-repair protein RAD52 containing surface mutations by Saotome, Mika, Saito, Kengo, Onodera, Keiichi, Kurumizaka, Hitoshi, Kagawa, Wataru

“…The Rad52 protein is a eukaryotic single‐strand DNA‐annealing protein that is involved in the homologous recombinational repair of DNA double‐strand breaks…”
Get full text

Abstract P3-09-12: Breast cancer derived GATA3 mutations disrupt luminal transcriptional network by Takaku, Motoki, Saotome, Mika, Nair, Renju

“…GATA3 has been identified as one of the most frequently mutated genes in breast cancer. In the METABRIC cohort, among 1,980 patient cases, 230 breast cancers…”
Get full text

Abstract 1700: Interplay of pioneer and chromatin remodeling factors: New insights into breast cancer mechanisms by Takaku, Motoki, Cooper, Mikhal, Saotome, Mika

“…Eukaryotic cells utilize chromatin to package their genomic DNA, which can hinder transcription factor binding and gene activation. Pioneer factors, which can…”
Get full text

Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome by Osumi, Ken, Kujirai, Tomoya, Ehara, Haruhiko, Ogasawara, Mitsuo, Kinoshita, Chiaki, Saotome, Mika, Kagawa, Wataru, Sekine, Shun-ichi, Takizawa, Yoshimasa, Kurumizaka, Hitoshi

“…[Display omitted] •During transcription-coupled repair, it is unclear how RNAPII recognizes DNA damage in the nucleosome.•Structures of RNAPII stalled at…”
Get full text

Autocrine GM-CSF signaling contributes to growth of HER2+ breast leptomeningeal carcinomatosis by Ansari, Khairul I., Bhan, Arunoday, Saotome, Mika, Tyagi, Antariksh, De Kumar, Bony, Chen, Clara, Takaku, Motoki, Jandial, Rahul

“…Leptomeningeal carcinomatosis (LC) occurs when tumor cells spread to the cerebrospinal fluid-containing leptomeninges surrounding the brain and spinal cord. LC…”
Get full text

Autocrine GMCSF Signaling Contributes to Growth of HER2 + Breast Leptomeningeal Carcinomatosis by Ansari, Khairul I, Bhan, Arunoday, Saotome, Mika, Tyagi, Antariksh, De Kumar, Bony, Chen, Clara, Takaku, Motoki, Jandial, Rahul

“…Leptomeningeal carcinomatosis (LC) occurs when tumor cells spread to the cerebrospinal fluid-containing leptomeninges surrounding the brain and spinal cord. LC…”
Get full text

Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4 by Saotome, Mika, Poduval, Deepak B, Grimm, Sara A, Nagornyuk, Aerica, Gunarathna, Sakuntha, Shimbo, Takashi, Wade, Paul A, Takaku, Motoki

“…Biologically precise enhancer licensing by lineage-determining transcription factors enables activation of transcripts appropriate to biological demand and…”
Get full text

Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein by Kagawa, Wataru, Arai, Naoto, Ichikawa, Yuichi, Saito, Kengo, Sugiyama, Shusei, Saotome, Mika, Shibata, Takehiko, Kurumizaka, Hitoshi

“…The Saccharomyces cerevisiae Rad52 protein is essential for efficient homologous recombination (HR). An important role of Rad52 in HR is the loading of Rad51…”
Get full text