Search Results - "Sao, Kimheak"

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages by Witherel, Claire E., Sao, Kimheak, Brisson, Becky K., Han, Biao, Volk, Susan W., Petrie, Ryan J., Han, Lin, Spiller, Kara L.

“…Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become…”
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Proteoglycan Dysfunction: A Common Link Between Intervertebral Disc Degeneration and Skeletal Dysplasia by Sao, Kimheak, Risbud, Makarand V.

“…Proteoglycans through their sulfated glycosaminoglycans regulate cell-matrix signaling during tissue development, regeneration, and degeneration processes…”
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Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc by Ohnishi, Takashi, Tran, Victoria, Sao, Kimheak, Ramteke, Pranay, Querido, William, Barve, Ruteja A., van de Wetering, Koen, Risbud, Makarand V.

“…Pathological mineralization of intervertebral disc is debilitating and painful and linked to disc degeneration in a subset of human patients. An adenosine…”
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Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine by Sao, Kimheak, Risbud, Makarand V.

“…•Syndecan 4 null mice show vertebral osteopenia, reduced bone stiffness, and functionally altered bone biomechanics.•Osteopenic phenotype in Sdc4 null mice is…”
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Myosin II and Arp2/3 cross-talk governs intracellular hydraulic pressure and lamellipodia formation by Patel, Shivani, McKeon, Donna, Sao, Kimheak, Yang, Changsong, Naranjo, Nicole M, Svitkina, Tatyana M, Petrie, Ryan J

“…Human fibroblasts can switch between lamellipodia-dependent and -independent migration mechanisms on two-dimensional surfaces and in three-dimensional (3D)…”
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Intracellular Pressure: A Driver of Cell Morphology and Movement by Chengappa, Pragati, Sao, Kimheak, Jones, Tia M, Petrie, Ryan J

“…Intracellular pressure, generated by actomyosin contractility and the directional flow of water across the plasma membrane, can rapidly reprogram cell shape…”
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Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms by Sao, Kimheak, Jones, Tia M, Doyle, Andrew D, Maity, Debonil, Schevzov, Galina, Chen, Yun, Gunning, Peter W, Petrie, Ryan J

“…Two-dimensional (2D) substrate rigidity promotes myosin II activity to increase traction force in a process negatively regulated by tropomyosin (Tpm) 2.1. We…”
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Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation by Tessier, Steven, Doolittle, Alexandra C, Sao, Kimheak, Rotty, Jeremy D, Bear, James E, Ulici, Veronica, Loeser, Richard F, Shapiro, Irving M, Diekman, Brian O, Risbud, Makarand V

“…Extracellular matrix and osmolarity influence the development and homeostasis of skeletal tissues through Rho GTPase-mediated alteration of the actin…”
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