Search Results - "Sanzone, Jillian R"

High Reactivity of Strained Seven-Membered-Ring trans-Alkenes by Sanzone, Jillian R., Woerpel, K. A.

“…trans‐Oxasilacycloheptenes are highly reactive strained alkenes. Competition reactions showed that these seven‐membered ring trans‐alkenes underwent [4+2]…”
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Uncatalyzed Carboboration of Seven-Membered-Ring trans-Alkenes: Formation of Air-Stable Trialkylboranes by Sanzone, Jillian R, Hu, Chunhua T, Woerpel, K. A

“…Seven-membered-ring trans-alkenes undergo rapid, uncatalyzed carboboration reactions to form trialkylboranes as single diastereomers. In contrast with other…”
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Acceleration of Acetal Hydrolysis by Remote Alkoxy Groups: Evidence for Electrostatic Effects on the Formation of Oxocarbenium Ions by Garcia, Angie, Otte, Douglas A. L., Salamant, Walter A., Sanzone, Jillian R., Woerpel, K. A.

“…In contrast to observations with carbohydrates, experiments with 4‐alkoxy‐substituted acetals indicate that an alkoxy group can accelerate acetal hydrolysis by…”
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Influence of Alkoxy Groups on Rates of Acetal Hydrolysis and Tosylate Solvolysis: Electrostatic Stabilization of Developing Oxocarbenium Ion Intermediates and Neighboring-Group Participation To Form Oxonium Ions by Garcia, Angie, Otte, Douglas A. L, Salamant, Walter A, Sanzone, Jillian R, Woerpel, K. A

“…The hydrolysis of 4-alkoxy-substituted acetals was accelerated by about 20-fold compared to that of sterically comparable substrates that do not have an alkoxy…”
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Microscale Purification with Direct Charged Aerosol Detector Quantitation Using Selective Online One- or Two-Dimensional Liquid Chromatography by Hettiarachchi, Kanaka, Streckfuss, Eric, Sanzone, Jillian R., Wang, Jun, Hayes, Michael, Kong, May, Greshock, Thomas J.

“…The pharmaceutical industry is increasingly faced with challenging separations of complex crude reaction mixtures at the microscale that require the adoption…”
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Carboalumination of Seven-Membered-Ring trans-Alkenes by Greene, Margaret A, Liu, Yudong, Sanzone, Jillian R, Woerpel, K. A

“…Seven-membered-ring trans-alkenes undergo rapid hydro- and carboalumination reactions in the absence of a catalyst with complete regio- and…”
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Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads by Patel, Akash M, Willingham, Aarron, Cheng, Alan C, Tomazela, Daniela, Bowman, Eddie, Kofman, Esther, Zhang, Fan, Bao, Jianming, Sanzone, Jillian R, Choy, Jonathan W, Flygare, John A, Han, Jin-Hwan, Pradhan, Komal, Kieffer, Madeleine, Chernyak, Natalia, Akbari, Peyman, Liu, Ping, Mehmood, Rimsha, Naravula, Saraswathi, Hollingsworth, Scott A, Bhagwat, Bhagyashree, Lang, Simon B, Seganish, W Michael

“…Toll-like receptors 7 and 8 are involved in modulating the adaptive and innate immune responses, and their activation has shown promise as a therapeutic…”
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[4+2] Cycloadditions of Seven-Membered-Ring trans-Alkenes: Decreasing Reactivity with Increasing Substitution of the Seven-Membered Ring by Santucci III, John, Sanzone, Jillian R., Woerpel, K. A.

“…The reactivity of trans‐oxasilacycloheptenes in [4+2] cycloadditions depends on the substitution pattern on the seven‐membered ring. Unhindered trans‐alkenes…”
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Participation of Alkoxy Groups in Reactions of Acetals: Violation of the Reactivity/Selectivity Principle in a Curtin-Hammett Kinetic Scenario by Garcia, Angie, Sanzone, Jillian R., Woerpel, K. A.

“…Nucleophilic substitution reactions of acetals having benzyloxy groups four carbon atoms away can be highly diastereoselective. The selectivity in several…”
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High Reactivity of Strained Seven-Membered-Ring trans-Alkenes by Sanzone, Jillian R., Woerpel, K. A.

“…trans‐Oxasilacycloheptenes are highly reactive strained alkenes. Competition reactions showed that these seven‐membered ring trans‐alkenes underwent [4+2]…”
Get full text

Participation of Alkoxy Groups in Reactions of Acetals: Violation of the Reactivity/Selectivity Principle in a Curtin-Hammett Kinetic Scenario by Garcia, Angie, Sanzone, Jillian R., Woerpel, K. A.

“…Nucleophilic substitution reactions of acetals having benzyloxy groups four carbon atoms away can be highly diastereoselective. The selectivity in several…”
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Acceleration of Acetal Hydrolysis by Remote Alkoxy Groups: Evidence for Electrostatic Effects on the Formation of Oxocarbenium Ions by Garcia, Angie, Otte, Douglas A. L., Salamant, Walter A., Sanzone, Jillian R., Woerpel, K. A.

“…In contrast to observations with carbohydrates, experiments with 4‐alkoxy‐substituted acetals indicate that an alkoxy group can accelerate acetal hydrolysis by…”
Get full text