Search Results - "Sanzari, Jenine K"

Analytical Concordance of PD-L1 Assays Utilizing Antibodies From FDA-Approved Diagnostics in Advanced Cancers: A Systematic Literature Review by Prince, Emily A, Sanzari, Jenine K, Pandya, Dimple, Huron, David, Edwards, Robin

“…Four programmed death ligand 1 (PD-L1) immunohistochemistry assays (28-8, 22C3, SP263, and SP142) have been approved for use by the US Food and Drug…”
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Distinct vascular genomic response of proton and gamma radiation-A pilot investigation by Ricciotti, Emanuela, Sarantopoulou, Dimitra, Grant, Gregory R, Sanzari, Jenine K, Krigsfeld, Gabriel S, Kiliti, Amber J, Kennedy, Ann R, Grosser, Tilo

“…The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the…”
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Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections by Li, Minghong, Holmes, Veronica, Zhou, Yu, Ni, Houping, Sanzari, Jenine K, Kennedy, Ann R, Weissman, Drew

“…A major risk of extended space travel is the combined effects of weightlessness and radiation exposure on the immune system. In this study, we used the…”
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Effect of solar particle event radiation and hindlimb suspension on gastrointestinal tract bacterial translocation and immune activation by Zhou, Yu, Ni, Houping, Li, Minghong, Sanzari, Jenine K, Diffenderfer, Eric S, Lin, Liyong, Kennedy, Ann R, Weissman, Drew

“…The environmental conditions that could lead to an increased risk for the development of an infection during prolonged space flight include: microgravity,…”
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The Predictive and Prognostic Nature of Programmed Death-Ligand 1 in Malignant Pleural Mesothelioma: A Systematic Literature Review by Mansfield, Aaron S., Brown, Rebecca J., Sammon, Cormac, Daumont, Melinda J., McKenna, Mike, Sanzari, Jenine K., Forde, Patrick M.

“…Given the emergence of combination of programmed cell death protein-1 and CTLA4 pathway blockade as effective treatment options in malignant pleural…”
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Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure by Sanzari, Jenine K, Romero-Weaver, Ana L, James, Gabrielle, Krigsfeld, Gabriel, Lin, Liyong, Diffenderfer, Eric S, Kennedy, Ann R

“…Immune system adaptation during spaceflight is a concern in space medicine. Decreased circulating leukocytes observed during and after space flight infer…”
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Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight by Li, Minghong, Holmes, Veronica, Ni, Houping, Sanzari, Jenine K, Romero-Weaver, Ana L, Lin, Liyong, Carabe-Fernandez, Alejandro, Diffenderfer, Eric S, Kennedy, Ann R, Weissman, Drew

“…A major risk for astronauts during prolonged space flight is infection as a result of the combined effects of microgravity, situational and confinement stress,…”
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Ionizing radiation selectively reduces skin regulatory T cells and alters immune function by Zhou, Yu, Ni, Houping, Balint, Klara, Sanzari, Jenine K, Dentchev, Tzvete, Diffenderfer, Eric S, Wilson, Jolaine M, Cengel, Keith A, Weissman, Drew

“…The skin serves multiple functions that are critical for life. The protection from pathogens is achieved by a complicated interaction between aggressive…”
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Comparative analysis of colorimetric staining in skin using open-source software by Billings, Paul C., Sanzari, Jenine K., Kennedy, Ann R., Cengel, Keith A., Seykora, John T.

“…Colorimetric staining techniques such as immunohistochemistry (IHC), immunofluorescence (IF) and histochemistry (HC) provide useful information regarding the…”
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Mechanism of hypocoagulability in proton-irradiated ferrets by Krigsfeld, Gabriel S., Savage, Alexandria R., Sanzari, Jenine K., Wroe, Andrew J., Gridley, Daila S., Kennedy, Ann R.

“…Abstract Purpose: To determine the mechanism of proton radiation- induced coagulopathy. Material and methods: Ferrets were exposed to either solar particle…”
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Protective Effects of Dietary Antioxidants on Proton Total-Body Irradiation-Mediated Hematopoietic Cell and Animal Survival by Wambi, Chris O., Sanzari, Jenine K., Sayers, Carly M., Nuth, Manunya, Zhou, Zhaozong, Davis, James, Finnberg, Niklas, Lewis-Wambi, Joan S., Ware, Jeffrey H., El-Deiry, Wafik S., Kennedy, Ann R.

“…Dietary antioxidants have radioprotective effects after γ-radiation exposure that limit hematopoietic cell depletion and improve animal survival. The purpose…”
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A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments by Kennedy, Ann R., Maity, Amit, Sanzari, Jenine K.

“…Results from our recent studies have led to the novel hypothesis that radiation-induced coagulopathy (RIC) and associated hemorrhage occurring as part of the…”
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Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model by Sanzari, Jenine K., Wan, Steven X., Diffenderfer, Eric S., Cengel, Keith A., Kennedy, Ann R.

“…The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral…”
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Comparison of hindlimb unloading and partial weight suspension models for spaceflight-type condition induced effects on white blood cells by Wilson, Jolaine M, Krigsfeld, Gabriel S., Sanzari, Jenine K., Wagner, Erika B., Mick, Rosemarie, Kennedy, Ann R.

“…Animal models are frequently used to assist in the determination of the long- and short-term effects of space flight. The space environment, including…”
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Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation by Diffenderfer, Eric S., Dolney, Derek, Schaettler, Maximilian, Sanzari, Jenine K., Mcdonough, James, Cengel, Keith A.

“…The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events…”
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Pencil beam scanning dosimetry for large animal irradiation by Lin, Liyong, Solberg, Timothy D., Carabe, Alexandro, Mcdonough, James E., Diffenderfer, Eric, Sanzari, Jenine K., Kennedy, Ann R., Cengel, Keith

“…The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event. These events consist…”
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The effects of proton radiation on the prothrombin and partial thromboplastin times of irradiated ferrets by Krigsfeld, Gabriel S., Sanzari, Jenine K., Kennedy, Ann R.

“…Purpose: To determine whether proton radiation affects coagulation. Material and methods: Ferrets were exposed to solar particle event-like proton radiation at…”
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Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure by Maks, Casey J., Wan, X. Steven, Ware, Jeffrey H., Romero-Weaver, Ana L., Sanzari, Jenine K., Wilson, Jolaine M., Rightnar, Steve, Wroe, Andrew J., Koss, Peter, Gridley, Daila S., Slater, James M., Kennedy, Ann R.

“…In the coming decades human space exploration is expected to move beyond low-Earth orbit. This transition involves increasing mission time and therefore an…”
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Induction of Cytokine Gene Expression in Human Thyroid Epithelial Cells Irradiated with HZE Particles (Iron Ions) by Sanzari, Jenine K., Nuth, Manunya, Kennedy, Ann R.

“…Gene expression profiles were examined using cDNA microarray technology in human thyroid epithelial (Htori-3) cells exposed to a low, non-toxic dose (10 cGy)…”
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Acute hematological effects in mice exposed to the expected doses, dose-rates, and energies of solar particle event-like proton radiation by Sanzari, Jenine K., Cengel, Keith A., Steven Wan, X., Rusek, Adam, Kennedy, Ann R.

“…NASA has funded several projects that have provided evidence for the radiation risk in space. One radiation concern arises from solar particle event (SPE)…”
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