Search Results - "Sanz Juste, Sara"
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A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins
Published in Cell reports (Cambridge) (29-08-2023)“…Development of effective therapies against SARS-CoV-2 infections relies on mechanistic knowledge of virus-host interface. Abundant physical interactions…”
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Next-generation CRISPR gene-drive systems using Cas12a nuclease
Published in Nature communications (12-10-2023)“…One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their…”
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Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives
Published in Molecular cell (15-10-2020)“…CRISPR-Cas9-based gene drive systems possess the inherent capacity to spread progressively throughout target populations. Here we describe two self-copying (or…”
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A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in Drosophila
Published in Cell reports (Cambridge) (24-05-2022)“…CRISPR-based gene-drives have been proposed for managing insect populations, including disease-transmitting mosquitoes, due to their ability to bias their…”
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Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells
Published in Science advances (01-07-2022)“…Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise…”
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