Search Results - "Sanz, Libia"

Integrated Venomics and Venom Gland Transcriptome Analysis of Juvenile and Adult Mexican Rattlesnakes Crotalus simus, C. tzabcan, and C. culminatus Revealed miRNA-modulated Ontogenetic Shifts by Durban, Jordi, Sanz, Libia, Trevisan-Silva, Dilza, Neri-Castro, Edgar, Alagón, Alejandro, Calvete, Juan J

“…Adult rattlesnakes within genus Crotalus express one of two distinct venom phenotypes, type I (hemorrhagic) and type II (neurotoxic). In Costa Rican Central…”
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Venoms, venomics, antivenomics by Calvete, Juan J., Sanz, Libia, Angulo, Yamileth, Lomonte, Bruno, Gutiérrez, José María

“…Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic…”
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Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms by Casewell, Nicholas R., Wagstaff, Simon C., Wüster, Wolfgang, Cook, Darren A. N., Bolton, Fiona M. S., King, Sarah I., Pla, Davinia, Sanz, Libia, Calvete, Juan J., Harrison, Robert A.

“…Variation in venom composition is a ubiquitous phenomenon in snakes and occurs both interspecifically and intraspecifically. Venom variation can have severe…”
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king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system by Vonk, Freek J., Casewell, Nicholas R., Henkel, Christiaan V., Heimberg, Alysha M., Jansen, Hans J., McCleary, Ryan J. R., Kerkkamp, Harald M. E., Vos, Rutger A., Guerreiro, Isabel, Calvete, Juan J., Wüster, Wolfgang, Woods, Anthony E., Logan, Jessica M., Harrison, Robert A., Castoe, Todd A., de Koning, A. P. Jason, Pollock, David D., Yandell, Mark, Calderon, Diego, Renjifo, Camila, Currier, Rachel B., Salgado, David, Pla, Davinia, Sanz, Libia, Hyder, Asad S., Ribeiro, José M. C., Arntzen, Jan W., van den Thillart, Guido E. E. J. M., Boetzer, Marten, Pirovano, Walter, Dirks, Ron P., Spaink, Herman P., Duboule, Denis, McGlinn, Edwina, Kini, Manjunatha, Richardson, Michael K.

“…Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by…”
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Exploring the Venom Proteome of the Western Diamondback Rattlesnake, Crotalus atrox, via Snake Venomics and Combinatorial Peptide Ligand Library Approaches by Calvete, Juan J, Fasoli, Elisa, Sanz, Libia, Boschetti, Egisto, Righetti, Pier Giorgio

“…We report the proteomic characterization of the venom of the medically important North American western diamondback rattlesnake, Crotalus atrox, using two…”
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Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead by Gutiérrez, José María, Solano, Gabriela, Pla, Davinia, Herrera, María, Segura, Álvaro, Vargas, Mariángela, Villalta, Mauren, Sánchez, Andrés, Sanz, Libia, Lomonte, Bruno, León, Guillermo, Calvete, Juan J

“…Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of…”
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What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus by Pla, Davinia, Sanz, Libia, Whiteley, Gareth, Wagstaff, Simon C., Harrison, Robert A., Casewell, Nicholas R., Calvete, Juan J.

“…Non-front-fanged colubroid snakes comprise about two-thirds of extant ophidian species. The medical significance of the majority of these snakes is unknown,…”
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Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations by Alape-Girón, Alberto, Sanz, Libia, Escolano, José, Flores-Díaz, Marietta, Madrigal, Marvin, Sasa, Mahmood, Calvete, Juan J

“…We report the comparative proteomic characterization of the venoms of adult and newborn specimens of the lancehead pitviper Bothrops asper from two…”
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Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing by Durban, Jordi, Juárez, Paula, Angulo, Yamileth, Lomonte, Bruno, Flores-Diaz, Marietta, Alape-Girón, Alberto, Sasa, Mahmood, Sanz, Libia, Gutiérrez, José M, Dopazo, Joaquín, Conesa, Ana, Calvete, Juan J

“…A long term research goal of venomics, of applied importance for improving current antivenom therapy, but also for drug discovery, is to understand the…”
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Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam by Pla, Davinia, Petras, Daniel, Saviola, Anthony J., Modahl, Cassandra M., Sanz, Libia, Pérez, Alicia, Juárez, Elena, Frietze, Seth, Dorrestein, Pieter C., Mackessy, Stephen P., Calvete, Juan J.

“…The Brown Treesnake (Boiga irregularis) is an arboreal, nocturnal, rear-fanged venomous snake native to northern and eastern regions of Australia, Papua New…”
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Phylogeny-based comparative analysis of venom proteome variation in a clade of rattlesnakes (Sistrurus sp.) by Gibbs, H Lisle, Sanz, Libia, Sovic, Michael G, Calvete, Juan J

“…A long-standing question in evolutionary studies of snake venoms is the extent to which phylogenetic divergence and diet can account for between-species…”
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Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage by Herrera, Cristina, Escalante, Teresa, Voisin, Mathieu-Benoit, Rucavado, Alexandra, Morazán, Diego, Macêdo, Jéssica Kele A, Calvete, Juan J, Sanz, Libia, Nourshargh, Sussan, Gutiérrez, José María, Fox, Jay W

“…Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze…”
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Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis) by Pla, Davinia, Sanz, Libia, Sasa, Mahmood, Acevedo, Manuel E., Dwyer, Quetzal, Durban, Jordi, Pérez, Alicia, Rodriguez, Yania, Lomonte, Bruno, Calvete, Juan J.

“…Bothriechis is a genus of eleven currently recognized slender and arboreal venomous snakes, commonly called palm-pitvipers that range from southern Mexico to…”
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Insights into the Evolution of a Snake Venom Multi-Gene Family from the Genomic Organization of Echis ocellatus SVMP Genes by Sanz, Libia, Calvete, Juan J

“…The molecular events underlying the evolution of the Snake Venom Metalloproteinase (SVMP) family from an A Disintegrin And Metalloproteinase (ADAM) ancestor…”
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Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming by Gutiérrez, José María, Lomonte, Bruno, León, Guillermo, Alape-Girón, Alberto, Flores-Díaz, Marietta, Sanz, Libia, Angulo, Yamileth, Calvete, Juan J.

“…Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global…”
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Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism by Núñez, Vitelbina, Cid, Pedro, Sanz, Libia, De La Torre, Pilar, Angulo, Yamileth, Lomonte, Bruno, Gutiérrez, José María, Calvete, Juan J.

“…The venom proteomes of Bothrops atrox from Colombia, Brazil, Ecuador, and Perú were characterized using venomic and antivenomic strategies. Our results…”
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Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management by Calvete, Juan J., Sanz, Libia, Pérez, Alicia, Borges, Adolfo, Vargas, Alba M., Lomonte, Bruno, Angulo, Yamileth, Gutiérrez, José María, Chalkidis, Hipócrates M., Mourão, Rosa H.V., Furtado, M. Fatima D., Moura-Da-Silva, Ana M.

“…We describe two geographically differentiated venom phenotypes across the wide distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley…”
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Venom On-a-Chip: A Fast and Efficient Method for Comparative Venomics by Zancolli, Giulia, Sanz, Libia, Calvete, Juan J, Wüster, Wolfgang

“…Venom research has attracted an increasing interest in disparate fields, from drug development and pharmacology, to evolutionary biology and ecology, and…”
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Omics meets biology: application to the design and preclinical assessment of antivenoms by Calvete, Juan J, Sanz, Libia, Pla, Davinia, Lomonte, Bruno, Gutiérrez, José María

“…Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in…”
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Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms by Madrigal, Marvin, Pla, Davinia, Sanz, Libia, Barboza, Elexandra, Arroyo-Portilla, Cynthia, Corrêa-Netto, Carlos, Gutiérrez, José María, Alape-Girón, Alberto, Flores-Díaz, Marietta, Calvete, Juan J

“…Bothrops, Crotalus and Lachesis represent the most medically relevant genera of pitvipers in Central and South America. Similarity in venom phenotype and…”
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