Search Results - "Sanz, Inãki"

GLaMST: grow lineages along minimum spanning tree for b cell receptor sequencing data by Yang, Xingyu, Tipton, Christopher M, Woodruff, Matthew C, Zhou, Enlu, Lee, F Eun-Hyung, Sanz, Inãki, Qiu, Peng

“…B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor…”
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B cells instruct their own fate through IL-12 by Sanz, Iñaki

“…Extrafollicular and germinal center reactions are considered to represent sequential phases of a primary B cell response. A study now demonstrates the ability…”
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New Perspectives in Rheumatology: May You Live in Interesting Times: Challenges and Opportunities in Lupus Research by Sanz, Iñaki

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May you live in interesting times: challenges and opportunities in Lupus research by Sanz, Iñaki

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Extent and patterns of off-label use of rituximab for SLE by Sanz, Iñaki

“…Despite conflicting evidence from clinical trials, rituximab continues to be used off-label in the treatment of systemic lupus erythematosus (SLE). A new study…”
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B cells as therapeutic targets for rheumatic diseases by Looney, R John, Anolik, Jennifer, Sanz, Inãki

“…PURPOSE OF REVIEWTrials treating human rheumatic diseases with biologic agents and drugs that selectively affect B cells will be reviewed. Rituximab, an…”
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Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus by Tipton, Christopher M, Fucile, Christopher F, Darce, Jaime, Chida, Asiya, Ichikawa, Travis, Gregoretti, Ivan, Schieferl, Sandra, Hom, Jennifer, Jenks, Scott, Feldman, Ron J, Mehr, Ramit, Wei, Chungwen, Lee, F Eun-Hyung, Cheung, Wan Cheung, Rosenberg, Alexander F, Sanz, Iñaki

“…Patients with systemic lupus erythematosus (SLE) experience flares of autoantibody secretion. Sanz and colleagues track the plasma cell repertoires of patients…”
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Epigenetic programming underpins B cell dysfunction in human SLE by Scharer, Christopher D., Blalock, Emily L., Mi, Tian, Barwick, Benjamin G., Jenks, Scott A., Deguchi, Tsuneo, Cashman, Kevin S., Neary, Bridget E., Patterson, Dillon G., Hicks, Sakeenah L., Khosroshahi, Arezou, Eun-Hyung Lee, F., Wei, Chungwen, Sanz, Iñaki, Boss, Jeremy M.

“…Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naive cells. Although…”
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Dysregulation of germinal centres in autoimmune disease by Vinuesa, Carola G, Sanz, Iñaki, Cook, Matthew C

“…Key Points Long-lived high-affinity antibody responses are key components of adaptive immunity. High-affinity antibodies are the products of somatic…”
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Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy by Palanichamy, Arumugam, Barnard, Jennifer, Zheng, Bo, Owen, Teresa, Quach, Tam, Wei, Chungwen, Looney, R. John, Sanz, Inaki, Anolik, Jennifer H

“…Transitional cells represent a crucial step in the differentiation and selection of the mature B cell compartment. Human transitional B cells have previously…”
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Factors Affecting Early Antibody Secreting Cell Maturation Into Long-Lived Plasma Cells by Nguyen, Doan C, Joyner, Chester J, Sanz, Iñaki, Lee, F Eun-Hyung

“…Antibody secreting cells (ASCs) are terminally differentiated cells of the humoral immune response and must adapt morphologically, transcriptionally, and…”
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Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion by Nguyen, Doan C., Garimalla, Swetha, Xiao, Haopeng, Kyu, Shuya, Albizua, Igor, Galipeau, Jacques, Chiang, Kuang-Yueh, Waller, Edmund K., Wu, Ronghu, Gibson, Greg, Roberson, James, Lund, Frances E., Randall, Troy D., Sanz, Iñaki, Lee, F. Eun-Hyung

“…Human antibody-secreting cells (ASC) in peripheral blood are found after vaccination or infection but rapidly apoptose unless they migrate to the bone marrow…”
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A New Population of Cells Lacking Expression of CD27 Represents a Notable Component of the B Cell Memory Compartment in Systemic Lupus Erythematosus by Wei, Chungwen, Anolik, Jennifer, Cappione, Amedeo, Zheng, Bo, Pugh-Bernard, Aimee, Brooks, James, Lee, Eun-Hyung, Milner, Eric C. B, Sanz, Inaki

“…Human memory B cells comprise isotype-switched and nonswitched cells with both subsets displaying somatic hypermutation. In addition to somatic hypermutation,…”
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Rationale for B cell targeting in SLE by Sanz, Iñaki

“…B cells are central pathogenic players in systemic lupus erythematosus and multiple other autoimmune diseases through antibody production as well as antibody…”
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Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow by Halliley, Jessica L, Tipton, Christopher M, Liesveld, Jane, Rosenberg, Alexander F, Darce, Jaime, Gregoretti, Ivan V, Popova, Lana, Kaminiski, Denise, Fucile, Christopher F, Albizua, Igor, Kyu, Shuya, Chiang, Kuang-Yueh, Bradley, Kyle T, Burack, Richard, Slifka, Mark, Hammarlund, Erika, Wu, Hao, Zhao, Liping, Walsh, Edward E, Falsey, Ann R, Randall, Troy D, Cheung, Wan Cheung, Sanz, Iñaki, Lee, F Eun-Hyung

“…Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans…”
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Updates on B-cell immunotherapies for systemic lupus erythematosus and Sjogrenʼs syndrome by Coca, Andreea, Sanz, Iñaki

“…PURPOSE OF REVIEWLast year was marked by important clinical and mechanistic studies that improved our understanding of B-cell immunotherapy for systemic lupus…”
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Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function by Portugal, Silvia, Tipton, Christopher M, Sohn, Haewon, Kone, Younoussou, Wang, Jing, Li, Shanping, Skinner, Jeff, Virtaneva, Kimmo, Sturdevant, Daniel E, Porcella, Stephen F, Doumbo, Ogobara K, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Sanz, Inaki, Pierce, Susan K, Crompton, Peter D

“…Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a…”
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B cells as therapeutic targets in SLE by Lee, F. Eun-Hyung, Sanz, Iñaki

“…B cells promote the pathogenesis of SLE in a number of ways. In this article, the authors provide an overview of the role of B cells in SLE, review the…”
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Phenotypic and functional heterogeneity of human memory B cells by Sanz, Iñaki, Wei, Chungwen, Lee, F. Eun-Hyung, Anolik, Jennifer

“…Abstract Memory B cells are more heterogeneous than previously thought. Given that B cells play powerful antibody-independent effector functions, it seems…”
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Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus by Gomez-Bañuelos, Eduardo, Yu, Yikai, Li, Jessica, Cashman, Kevin S., Paz, Merlin, Trejo-Zambrano, Maria Isabel, Bugrovsky, Regina, Wang, Youliang, Chida, Asiya Seema, Sherman-Baust, Cheryl A., Ferris, Dylan P., Goldman, Daniel W., Darrah, Erika, Petri, Michelle, Sanz, Iñaki, Andrade, Felipe

“…Anti-dsDNA antibodies are pathogenically heterogeneous, implying distinct origins and antigenic properties. Unexpectedly, during the clinical and molecular…”
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