Search Results - "Santos Passos, Fabiolla Rocha"
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Oxidative stress and inflammatory markers in patients with COVID-19: Potential role of RAGE, HMGB1, GFAP and COX-2 in disease severity
Published in International immunopharmacology (01-03-2022)“…•Several oxidative stress-related molecules can be used as COVID-19 severity markers.•Higher GFAP, HMGB1, RAGE and COX-2 plasma levels were found in severe…”
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Hecogenin and its derivates: A pharmacology review
Published in Biomedicine & pharmacotherapy (01-03-2023)“…Despite the several uses of drugs from natural compounds in the pharmaceutical industry, new molecules have been discovered and associated with pharmacological…”
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Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz
Published in Journal of ethnopharmacology (23-05-2020)“…Poncianella pyramidalis (Leguminosae) is a Caatinga plant used in folk medicine because of its pharmacological properties, which include anti-inflammatory…”
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Pharmacological effects of a complex α-bisabolol/β-cyclodextrin in a mice arthritis model with involvement of IL-1β, IL-6 and MAPK
Published in Biomedicine & pharmacotherapy (01-07-2022)“…Inflammatory arthritis is the most prevalent chronic inflammatory disease worldwide. The pathology of the disease is characterized by increased inflammation…”
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Chrysin-Loaded Microemulsion: Formulation Design, Evaluation and Antihyperalgesic Activity in Mice
Published in Applied sciences (01-01-2022)“…Chrysin is a bioactive flavonoid found in pollens, passion flowers, honey, royal jelly, and propolis, which is commonly used as an ingredient in natural food…”
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Enhancing orofacial pain relief: α-phellandrene complexed with hydroxypropyl-β-cyclodextrin mitigates orofacial nociception in rodents
Published in Naunyn-Schmiedeberg's archives of pharmacology (04-11-2024)“…Orofacial pain affects 10-15% of adults and can severely impact quality of life. Despite ongoing treatment challenges, monoterpene alpha-phellandrene (PHE)…”
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Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice
Published in Molecules (Basel, Switzerland) (07-05-2020)“…Nootkatone (NTK) is a sesquiterpenoid found in essential oils of many species of (Rutaceae). Considering previous reports demonstrating that NTK inhibited…”
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Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease – A systematic review
Published in International immunopharmacology (01-06-2022)“…•Systematic review that shows the GFAP as a biomarker to detect neurological disorder.•Serum levels of GFAP is a useful prognostic tool for neurological…”
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Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research
Published in Phytomedicine (Stuttgart) (01-02-2022)“…Saponins are glycosides which, after acid hydrolysis, liberate sugar(s) and an aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal…”
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Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways
Published in Neuropharmacology (15-03-2021)“…Neuropathic pain develops due to injury to the somatosensory system, affecting the patient's quality of life. In view of the ineffectiveness of the current…”
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Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement
Published in International immunopharmacology (01-09-2020)“…•POH and LIM improve the regeneration process.•POH and LIM improve the sensory and motor function recovery.•These effects are due the anti-inflammatory effect…”
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Naringenin complexed with hydroxypropyl-β-cyclodextrin improves the sciatic nerve regeneration through inhibition of p75NTR and JNK pathway
Published in Life sciences (1973) (15-01-2020)“…Peripheral nerve injuries are common conditions that often lead to dysfunctions. Although much knowledge exists on the several factors that mediate the complex…”
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Naringenin complexed with hydroxypropyl-β-cyclodextrin improves the sciatic nerve regeneration through inhibition of p75 NTR and JNK pathway
Published in Life sciences (1973) (15-01-2020)“…Peripheral nerve injuries are common conditions that often lead to dysfunctions. Although much knowledge exists on the several factors that mediate the complex…”
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