Search Results - "Santos Nascimento, Igor José"

Targeting Cysteine and Serine Proteases to Discover New Drugs Against Neglected Tropical Diseases by Dos Santos Nascimento, Igor José, de Moura, Ricardo Olimpio

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Cruzain and Rhodesain Inhibitors: Last Decade of Advances in Seeking for New Compounds Against American and African Trypanosomiases by Dos Santos Nascimento, Igor José, de Aquino, Thiago Mendonça, da Silva-Júnior, Edeildo Ferreira

“…Neglected tropical diseases (NTDs) are a group of approximately 20 diseases that affect part of the population in Sub- and Tropical countries. In the past,…”
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Overview of the New Bioactive Heterocycles as Targeting Topoisomerase Inhibitors Useful Against Colon Cancer by Santos, Mirelly Barbosa, de Azevedo Teotônio Cavalcanti, Misael, de Medeiros E Silva, Yvnni Maria Sales, Dos Santos Nascimento, Igor José, de Moura, Ricardo Olimpio

“…Colorectal cancer (CRC) is the third most common cancer globally, with high mortality. Metastatic CRC is incurable in most cases, and multiple drug therapy can…”
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Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses by Dos Santos Nascimento, Igor José, da Silva-Júnior, Edeildo Ferreira, de Aquino, Thiago Mendonça

“…Since December 2019, the new Coronavirus disease (COVID-19) caused by the etiological agent SARS-CoV-2 has been responsible for several cases worldwide,…”
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Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria by Monteiro, Kadja Luana Chagas, Silva, Osmar Nascimento, Dos Santos Nascimento, Igor José, Mendonça Júnior, Francisco Jaime Bezerra, Aquino, Pedro Gregório Vieira, da Silva-Júnior, Edeildo Ferreira, de Aquino, Thiago Mendonça

“…The discovery of antibiotics was a revolutionary feat that provided countless health benefits. The identification of penicillin by Alexander Fleming initiated…”
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Computer-aided Drug Design against Emerging Viruses: Part I by Dos Santos Nascimento, Igor José

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C-KIT Receptor Inhibition as a Promising Approach to Design Anticancer Drugs by Dos Santos Nascimento, Igor José, de Moura, Ricardo Olimpio

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TNF-α Inhibitors from Natural Compounds: An Overview, CADD Approaches, and their Exploration for Anti-inflammatory Agents by Dos Santos Nascimento, Igor José, da Silva-Júnior, Edeildo Ferreira

“…Inflammation is a natural process that occurs in the organism in response to harmful external agents. Despite being considered beneficial, exaggerated cases…”
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Molecular Dynamics Simulations in Drug Discovery by Dos Santos Nascimento, Igor José, de Moura, Ricardo Olimpio

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Pharmacokinetic Limitations to Overcome and Enable K777 as a Potential Drug against Chagas Disease by De Souza, Marianny, Medeiros, Daniel Calazans, de Moura, Ricardo Olimpio, Dos Santos Nascimento, Igor José

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Targeting SmCB1: Perspectives and Insights to Design Antischistosomal Drugs by Dos Santos Nascimento, Igor José, Albino, Sonaly Lima, da Silva Menezes, Karla Joane, de Azevedo Teotônio Cavalcanti, Misael, de Oliveira, Mozaniel Santana, Mali, Suraj N, de Moura, Ricardo Olimpio

“…Neglected tropical diseases (NTDs) are prevalent in tropical and subtropical countries, and schistosomiasis is among the most relevant diseases worldwide. In…”
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Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains by Araújo, Ana Carolina Justino, Freitas, Priscilla Ramos, Araújo, Isaac Moura, Siqueira, Gustavo Miguel, Oliveira Borges, João Arthur, Alves, Daniel Sampaio, Miranda, Gustavo Marinho, Santos Nascimento, Igor José, Araújo‐Júnior, João Xavier, Silva‐Júnior, Edeildo Ferreira, Aquino, Thiago Mendonça, Junior, Francisco Jaime Bezerra Mendonça, Marinho, Emmanuel Silva, Santos, Helcio Silva, Tintino, Saulo Relison, Coutinho, Henrique Douglas Melo

“…Background Thiadiazines are heterocyclic compounds that contain two nitrogen atoms and one sulfur atom in their structure. These synthetic molecules have…”
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The new psychoactive substances 25H-NBOMe and 25H-NBOH induce abnormal development in the zebrafish embryo and interact in the DNA major groove by de Barros, Wellington Alves, Nunes, Camila da Silva, Souza, Juliana Alves da Costa Ribeiro, Nascimento, Igor José dos Santos, Figueiredo, Isis Martins, de Aquino, Thiago Mendonça, Vieira, Leonardo, Farias, Davi, Santos, Josué Carinhanha Caldas, de Fátima, Ângelo

“…[Display omitted] •25H-NBOMe and 25H-NBOH recreational drugs induces abnormal formation in zebrafish embryos.•Biophysical and theoretical studies indicate that…”
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Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors by Nascimento, Igor José dos Santos, Santos-Júnior, Paulo Fernando da Silva, Aquino, Thiago Mendonça de, Araújo-Júnior, João Xavier de, Silva-Júnior, Edeildo Ferreira da

“…Over recent years, many outbreaks caused by (re)emerging RNA viruses have been reported worldwide, including life-threatening Flaviviruses, such as Dengue…”
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The influence of N-alkyl chains in benzoyl-thiourea derivatives on urease inhibition: Soil studies and biophysical and theoretical investigations on the mechanism of interaction by Tavares, Maria Célia, dos Santos Nascimento, Igor José, de Aquino, Thiago Mendonça, de Oliveira Brito, Tiago, Macedo, Fernando, Modolo, Luzia Valentina, de Fátima, Ângelo, Santos, Josué Carinhanha C.

“…Ureases are enzymes produced by fungi, plants, and bacteria associated with agricultural and clinical problems. The urea hydrolysis in NH3 and CO2 leads to the…”
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Would the Development of a Multitarget Inhibitor of 3CL pro and TMPRSS2 be Promising in the Fight Against SARS-CoV-2? by Dos Santos Nascimento, Igor José, de Moura, Ricardo Olimpio

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), responsible for generating COVID-19, has spread worldwide and was declared a pandemic by the World…”
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Advances in Computational Methods to Discover New NS2B-NS3 Inhibitors Useful Against Dengue and Zika Viruses by Dos Santos Nascimento, Igor José, da Silva Rodrigues, Érica Erlanny, da Silva, Manuele Figueiredo, de Araújo-Júnior, João Xavier, de Moura, Ricardo Olimpio

“…The Flaviviridae virus family consists of the genera Hepacivirus, Pestivirus, and Flavivirus, with approximately 70 viral types that use arthropods as vectors…”
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A consensus reverse docking approach for identification of a competitive inhibitor of acetyltransferase enhanced intracellular survival protein from Mycobacterium tuberculosis by Santos-Júnior, Paulo Fernando da Silva, Batista, Vitoria de Melo, Nascimento, Igor José dos Santos, Nunes, Isabelle Cavalcante, Silva, Leandro Rocha, Costa, Clara Andrezza Crisóstomo Bezerra, Freitas, Johnnatan Duarte de, Quintans-Júnior, Lucindo José, Araújo-Júnior, João Xavier de, Freitas, Maria Eugênia G. de, Zhan, Peng, Green, Keith D., Garneau-Tsodikova, Sylvie, Mendonça-Júnior, Francisco Jaime Bezerra, Rodrigues-Junior, Valnês S., Silva-Júnior, Edeildo Ferreira da

“…[Display omitted] Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which remains a significant global health challenge…”
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The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors by Dos Santos Nascimento, Igor José, Gomes, Joilly Nilce Santana, de Oliveira Viana, Jéssika, de Medeiros E Silva, Yvnni Maria Sales, Barbosa, Euzébio Guimarães, de Moura, Ricardo Olimpio

“…A large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories…”
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ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation by Albino, Sonaly Lima, da Silva Moura, Willian Charles, Reis, Malu Maria Lucas Dos, Sousa, Gleyton Leonel Silva, da Silva, Pablo Rayff, de Oliveira, Mayara Gabriele Carvalho, Borges, Tatiana Karla Dos Santos, Albuquerque, Lucas Fraga Friaça, de Almeida, Sinara Mônica Vitalino, de Lima, Maria do Carmo Alves, Kuckelhaus, Selma Aparecida Souza, Nascimento, Igor José Dos Santos, Junior, Francisco Jaime Bezerra Mendonca, da Silva, Teresinha Gonçalves, de Moura, Ricardo Olímpio

“…The present study proposed the synthesis of a novel acridine derivative not yet described in the literature, chemical characterization by NMR, MS, and IR,…”
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