Search Results - "Santos Martínez, Nancy"

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer by Totten, Stephanie P., Im, Young Kyuen, Cepeda Cañedo, Eduardo, Najyb, Ouafa, Nguyen, Alice, Hébert, Steven, Ahn, Ryuhjin, Lewis, Kyle, Lebeau, Benjamin, La Selva, Rachel, Sabourin, Valérie, Martínez, Constanza, Savage, Paul, Kuasne, Hellen, Avizonis, Daina, Santos Martínez, Nancy, Chabot, Catherine, Aguilar-Mahecha, Adriana, Goulet, Marie-Line, Dankner, Matthew, Witcher, Michael, Petrecca, Kevin, Basik, Mark, Pollak, Michael, Topisirovic, Ivan, Lin, Rongtuan, Siegel, Peter M., Kleinman, Claudia L., Park, Morag, St-Pierre, Julie, Ursini-Siegel, Josie

“…Bioenergetic perturbations driving neoplastic growth increase the production of reactive oxygen species (ROS), requiring a compensatory increase in ROS…”
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Calcitriol stimulates gene expression of cathelicidin antimicrobial peptide in breast cancer cells with different phenotype by García-Quiroz, Janice, García-Becerra, Rocío, Santos-Martínez, Nancy, Avila, Euclides, Larrea, Fernando, Díaz, Lorenza

“…In normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial…”
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Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies by García, Santiago, Mercado-Sánchez, Itzel, Bahena, Luis, Alcaraz, Yolanda, García-Revilla, Marco A, Robles, Juvencio, Santos-Martínez, Nancy, Ordaz-Rosado, David, García-Becerra, Rocío, Vazquez, Miguel A

“…Coumarin-hydroxamic acid derivatives - were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were…”
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In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors by García-Quiroz, Janice, García-Becerra, Rocío, Santos-Martínez, Nancy, Barrera, David, Ordaz-Rosado, David, Avila, Euclides, Halhali, Ali, Villanueva, Octavio, Ibarra-Sánchez, Maŕa J, Esparza-López, José, Gamboa-Domínguez, Armando, Camacho, Javier, Larrea, Fernando, Díaz, Lorenza

“…The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D…”
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Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach by Santos-Martínez, Nancy, Díaz, Lorenza, Ordaz-Rosado, David, García-Quiroz, Janice, Barrera, David, Avila, Euclides, Halhali, Ali, Medina-Franco, Heriberto, Ibarra-Sánchez, María J, Esparza-López, José, Camacho, Javier, Larrea, Fernando, García-Becerra, Rocío

“…Approximately 30% of breast tumors do not express the estrogen receptor (ER) α, which is necessary for endocrine therapy approaches. Studies are ongoing in…”
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Calcitriol induces estrogen receptor α expression through direct transcriptional regulation and epigenetic modifications in estrogen receptor-negative breast cancer cells by Santos-Martínez, Nancy, Díaz, Lorenza, Ortiz-Ortega, Victor M, Ordaz-Rosado, David, Prado-Garcia, Heriberto, Avila, Euclides, Larrea, Fernando, García-Becerra, Rocío

“…Patients with estrogen receptor (ER) α-negative breast tumors have a poor prognosis and are not suitable for hormone therapy. Previously, we demonstrated that…”
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Exploring novel capping framework: high substituent pyridine-hydroxamic acid derivatives as potential antiproliferative agents by Hernández-Borja, Fernando, Mercado-Sánchez, Itzel, Alcaraz, Yolanda, García-Revilla, Marco A., Villegas Gómez, Clarisa, Ordaz-Rosado, David, Santos-Martínez, Nancy, García-Becerra, Rocío, Vazquez, Miguel A.

“…Purpose Histone deacetylases (HDACs) play a vital role in the epigenetic regulation of gene expression due to their overexpression in several cancer forms…”
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Chronic moderate ethanol intake differentially regulates vitamin D hydroxylases gene expression in kidneys and xenografted breast cancer cells in female mice by García-Quiroz, Janice, García-Becerra, Rocío, Lara-Sotelo, Galia, Avila, Euclides, López, Sofía, Santos-Martínez, Nancy, Halhali, Ali, Ordaz-Rosado, David, Barrera, David, Olmos-Ortiz, Andrea, Ibarra-Sánchez, María J., Esparza-López, José, Larrea, Fernando, Díaz, Lorenza

“…[Display omitted] •Moderate ethanol intake decreased renal Cyp27b1 gene expression.•Moderate ethanol intake increased tumoral CYP24A1 gene…”
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Abstract 4108: The use of conditionally reprogrammed cells for high throughput screening for novel drug combinations to treat drug resistant triple negative breast cancers by Aguilar-Mahecha, Adriana, Chabot, Catherine, Santos-Martinez, Nancy, Darini, Cedric, Hajira, Midhet, Kong, Tim, Morin, Genevieve, Huang, Sidong, Park, Morag, Basik, Mark

“…Abstract Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer, with prognosis tightly dependent on its responsiveness to cytotoxic…”
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Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis by García-Quiroz, Janice, Rivas-Suárez, Mariana, García-Becerra, Rocío, Barrera, David, Martínez-Reza, Isela, Ordaz-Rosado, David, Santos-Martinez, Nancy, Villanueva, Octavio, Santos-Cuevas, Clara L., Avila, Euclides, Gamboa-Domínguez, Armando, Halhali, Ali, Larrea, Fernando, Díaz, Lorenza

“…•Serum VEGF was significantly elevated in calcitriol-treated mice.•Calcitriol reduced thrombospondin-1 mRNA expression and protein in breast cancer.•Calcitriol…”
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