Chemical composition and biological activities of the essential oils from Lippia alba and Lippia origanoides

There is an increasing interest in essential oils extracted from Verbenaceae plant species as potential sources of biologically active compounds that could provide a starting point for designing novel phyto-pharmaceuticals in aquaculture. The present study was aimed to investigate the chemical compo...

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Published in:	Anais da Academia Brasileira de Ciências Vol. 95; no. 1; p. e20220359
Main Authors:	Santos Filho, Luiz G A Dos, Reis, Renata B Dos, Souza, Ana Sheila Q, Canuto, Kirley M, Brito, Edy S DE, Castro, Karina N C, Pereira, Alitiene M L, Diniz, Fábio Mendonça
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 2023
Subjects:	Antioxidants - pharmacology Gas Chromatography-Mass Spectrometry Lippia - chemistry MULTIDISCIPLINARY SCIENCES Oils, Volatile - chemistry Oils, Volatile - pharmacology Plant Oils - chemistry Plant Oils - pharmacology Verbenaceae Lippia alba Lippia origanoides oxygenated monoterpenes minimum bactericidal concentration minimum inhibitory concentration
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Summary:	There is an increasing interest in essential oils extracted from Verbenaceae plant species as potential sources of biologically active compounds that could provide a starting point for designing novel phyto-pharmaceuticals in aquaculture. The present study was aimed to investigate the chemical composition, antioxidant activity, acute toxicity and antimicrobial effects against Vibrio parahaemolyticus of essential oils extracted from Lippia alba and L. origanoides. Approximately 23 components were identified and quantified by gas chromatography-mass spectrometry and flame ionization detection in each species' essential oil. The most predominant compounds were geranial (23.0%), limonene (17.0%) and neral (15.5%) in L. alba, and thymol (47.2%), p-cymene (16.0%) and E-caryophyllene (11.3%) in L. origanoides. The essential oils have antibacterial activity against Vibrio parahaemolyticus presenting Minimum Inhibitory Concentration (MIC) and Bactericidal Concentration (MBC) values between 156-625 µg mL-1. The essential oils also show antioxidant potential estimated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays, presenting IC50 of 60.16 mg mL-1 and 0.22 mg mL-1 for L. alba and L. origanoides EO, respectively. Both oils were classified as toxic to Artemia salina nauplii. Therefore, these essential oils may be useful for controlling pathogenic bacteria important to the aquaculture industry.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690
DOI:	10.1590/0001-3765202320220359