Unveiling in Vivo Subcutaneous Thermal Dynamics by Infrared Luminescent Nanothermometers

Unveiling in Vivo Subcutaneous Thermal Dynamics by Infrared Luminescent Nanothermometers

The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, th...

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Bibliographic Details
Published in:Nano letters Vol. 16; no. 3; pp. 1695 - 1703
Main Authors: Ximendes, Erving Clayton, Santos, Weslley Queiroz, Rocha, Uéslen, Kagola, Upendra Kumar, Sanz-Rodríguez, Francisco, Fernández, Nuria, Gouveia-Neto, Artur da Silva, Bravo, David, Domingo, Agustín Martín, del Rosal, Blanca, Brites, Carlos D. S, Carlos, Luís Dias, Jaque, Daniel, Jacinto, Carlos
Format: Journal Article
Language:English
Published: United States American Chemical Society 09-03-2016
Subjects:
Administration, Cutaneous
Animals
Biological
Body Temperature
Detection
Infrared
Infrared Rays
Luminescence
Luminescent Measurements - instrumentation
Mice
Monitoring
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanostructure
Neodymium - administration & dosage
Neodymium - chemistry
Rare earth metals
Skin Physiological Phenomena
Thermometers
Ytterbium - administration & dosage
Ytterbium - chemistry
Nanothermometry
rare earth nanoparticles
second biological window
subcutaneous thermal sensing
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Summary:The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level.
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ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.5b04611