Search Results - "Santos, Raul D."

Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps by Santos, Raul D., Valenti, Luca, Romeo, Stefano

“…Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and includes a spectrum of abnormalities ranging from steatosis to cirrhosis. In this review, we…”
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Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity by Ross, Robert, Neeland, Ian J., Yamashita, Shizuya, Shai, Iris, Seidell, Jaap, Magni, Paolo, Santos, Raul D., Arsenault, Benoit, Cuevas, Ada, Hu, Frank B., Griffin, Bruce A., Zambon, Alberto, Barter, Philip, Fruchart, Jean-Charles, Eckel, Robert H., Matsuzawa, Yuji, Després, Jean-Pierre

“…Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of…”
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Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement by Neeland, Ian J, Ross, Robert, Després, Jean-Pierre, Matsuzawa, Yuji, Yamashita, Shizuya, Shai, Iris, Seidell, Jaap, Magni, Paolo, Santos, Raul D, Arsenault, Benoit, Cuevas, Ada, Hu, Frank B, Griffin, Bruce, Zambon, Alberto, Barter, Philip, Fruchart, Jean-Charles, Eckel, Robert H

“…Findings from epidemiological studies over the past 30 years have shown that visceral adipose tissue, accurately measured by CT or MRI, is an independent risk…”
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NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis by Tsimikas, Sotirios, Fazio, Sergio, Ferdinand, Keith C., Ginsberg, Henry N., Koschinsky, Marlys L., Marcovina, Santica M., Moriarty, Patrick M., Rader, Daniel J., Remaley, Alan T., Reyes-Soffer, Gissette, Santos, Raul D., Thanassoulis, George, Witztum, Joseph L., Danthi, Simhan, Olive, Michelle, Liu, Lijuan

“…Pathophysiological, epidemiological, and genetic studies provide strong evidence that lipoprotein(a) [Lp(a)] is a causal mediator of cardiovascular disease…”
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International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia by Watts, Gerald F., Gidding, Samuel S., Hegele, Robert A., Raal, Frederick J., Sturm, Amy C., Jones, Laney K., Sarkies, Mitchell N., Al-Rasadi, Khalid, Blom, Dirk J., Daccord, Magdalena, de Ferranti, Sarah D., Folco, Emanuela, Libby, Peter, Mata, Pedro, Nawawi, Hapizah M., Ramaswami, Uma, Ray, Kausik K., Stefanutti, Claudia, Yamashita, Shizuya, Pang, Jing, Thompson, Gilbert R., Santos, Raul D.

“…This contemporary, international, evidence-informed guidance aims to achieve the greatest good for the greatest number of people with familial…”
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Targeting PCSK9 for therapeutic gains: Have we addressed all the concerns? by Banerjee, Yajnavalka, Santos, Raul D, Al-Rasadi, Khalid, Rizzo, Manfredi

“…Abstract Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) regulates the expression of low-density lipoprotein (LDL)-receptors, through reducing their…”
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Lomitapide and Mipomersen—Inhibiting Microsomal Triglyceride Transfer Protein (MTP) and apoB100 Synthesis by Blom, Dirk J., Raal, Frederick J., Santos, Raul D., Marais, A. David

“…Purpose of Review The goal of this review is to evaluate the role of inhibiting the synthesis of lipoproteins when there is no or little residual LDL-receptor…”
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Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation by Watts, Gerald F, Gidding, Samuel, Wierzbicki, Anthony S, Toth, Peter P, Alonso, Rodrigo, Brown, W. Virgil, Bruckert, Eric, Defesche, Joep, Lin, Khoo Kah, Livingston, Michael, Mata, Pedro, Parhofer, Klaus G, Raal, Frederick J, Santos, Raul D, Sijbrands, Eric J.G, Simpson, William G, Sullivan, David R, Susekov, Andrey V, Tomlinson, Brian, Wiegman, Albert, Yamashita, Shizuya, Kastelein, John J.P

“…Abstract Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL)…”
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Uric acid: A marker of increased cardiovascular risk by Gagliardi, Ana C.M, Miname, Marcio H, Santos, Raul D

“…Abstract The relationship between uric acid and cardiovascular disease has been known since the 19th century, after that many authors reported the classical…”
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Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial by Raal, Frederick J, Prof, Santos, Raul D, MD, Blom, Dirk J, MD, Marais, A David, Prof, Charng, Min-Ji, MD, Cromwell, William C, MD, Lachmann, Robin H, MRCP, Gaudet, Daniel, MD, Tan, Ju L, MB BS, Chasan-Taber, Scott, PhD, Tribble, Diane L, PhD, Flaim, JoAnn D, PhD, Crooke, Stanley T, MD

“…Summary Background Homozygous familial hypercholesterolaemia is a rare genetic disorder in which both LDL-receptor alleles are defective, resulting in very…”
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Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study by Raal, Frederick J, Prof, Hovingh, G Kees, PhD, Blom, Dirk, MD, Santos, Raul D, Prof, Harada-Shiba, Mariko, Prof, Bruckert, Eric, Prof, Couture, Patrick, MD, Soran, Handrean, Prof, Watts, Gerald F, Prof, Kurtz, Christopher, MD, Honarpour, Narimon, MD, Tang, Lihua, PhD, Kasichayanula, Sree, PhD, Wasserman, Scott M, MD, Stein, Evan A, Prof

“…Summary Background Homozygous familial hypercholesterolaemia is a genetic disorder characterised by substantially raised LDL cholesterol, reduced LDL receptor…”
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Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS) by Danchin, Nicolas, Almahmeed, Wael, Al-Rasadi, Khalid, Azuri, Joseph, Berrah, Abdelkrim, Cuneo, Carlos Alberto, Karpov, Yuri, Kaul, Upendra, Kayıkçıoğlu, Meral, Mitchenko, Olena, Ruiz, Alvaro J, Aguilar Salinas, Carlos A, Santos, Raul D, Mercier, Florence, Blom, Dirk

“…Background Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable…”
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The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta-analysis by Jamialahmadi, Tannaz, Reiner, Željko, Alidadi, Mona, Kroh, Matthew, Almahmeed, Wael, Ruscica, Massimiliano, Sirtori, Cesare, Rizzo, Manfredi, Santos, Raul D., Sahebkar, Amirhossein

“…Background. Obesity, especially severe obesity, is associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD) morbidity and mortality…”
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Effects of phytosterols on markers of inflammation: A systematic review and meta-analysis by Rocha, Viviane Z, Ras, Rouyanne T, Gagliardi, Ana C, Mangili, Leonardo C, Trautwein, Elke A, Santos, Raul D

“…Abstract Background and aims Regular intake of phytosterols (PS) is proven to dose-dependently lower LDL-cholesterol (LDL-C). Whether PS consumption can also…”
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World Heart Federation Cholesterol Roadmap 2022 by Ray, Kausik K., Ference, Brian A., Séverin, Tania, Blom, Dirk, Nicholls, Stephen J., Shiba, Mariko H., Almahmeed, Wael, Alonso, Rodrigo, Daccord, Magdalena, Ezhov, Marat, Olmo, Rosa Fernández, Jankowski, Piotr, Lanas, Fernando, Mehta, Roopa, Puri, Raman, Wong, Nathan D., Wood, David, Zhao, Dong, Gidding, Samuel S., Virani, Salim S., Lloyd-Jones, Donald, Pinto, Fausto, Perel, Pablo, Santos, Raul D.

“…BackgroundAtherosclerotic cardiovascular diseases (ASCVD) including myocardial infarction, stroke and peripheral arterial disease continue to be major causes…”
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Targeting PCSK9 as a key player in lipid metabolism: exploiting the therapeutic and biosensing potential of aptamers by Mahjoubin-Tehran, Maryam, Rezaei, Samaneh, Santos, Raul D, Jamialahmadi, Tannaz, Almahmeed, Wael, Sahebkar, Amirhossein

“…The degradation of low-density lipoprotein receptor (LDLR) is induced by proprotein convertase subtilisin/kexin type 9 (PCSK9), resulting in elevated plasma…”
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Marked HDL deficiency and premature coronary heart disease by Schaefer, Ernst J, Santos, Raul D, Asztalos, Bela F

“…Our purpose is to review recent publications in the area of marked human HDL deficiency, HDL particles, coronary heart disease (CHD), amyloidosis, the immune…”
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Prognostic utility of triglyceride-rich lipoprotein-related markers in patients with coronary artery disease by Cao, Ye-Xuan, Zhang, Hui-Wen, Jin, Jing-Lu, Liu, Hui-Hui, Zhang, Yan, Xu, Rui-Xia, Gao, Ying, Guo, Yuan-Lin, Zhu, Cheng-Gang, Hua, Qi, Li, Yan-Fang, Santos, Raul D., Wu, Na-Qiong, Li, Jian-Jun

“…TG-rich lipoprotein (TRL)-related biomarkers, including TRL-cholesterol (TRL-C), remnant-like lipoprotein particle-cholesterol (RLP-C), and apoC-III have been…”
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Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia by Duell, P. Barton, MD, Santos, Raul D., MD, MSc, PhD, Kirwan, Bridget-Anne, PhD, Witztum, Joseph L., MD, Tsimikas, Sotirios, MD, Kastelein, John J.P., MD, PhD

“…Background Familial hypercholesterolemia (FH) is characterized by severely elevated LDL-cholesterol and up to a 20-fold increase in premature cardiovascular…”
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Identification of Critical Genes Differentiating Stable and Unstable Atherosclerotic Plaques: A Bioinformatic and Computational Analysis by Mahjoubin-Tehran, Maryam, Santos, Raul D, Almahmeed, Wael, Al-Rasadi, Khalid, Sahebkar, Amirhossein

“…Identification of biomarkers to distinguish between stable and unstable plaque formation would be very useful to predict plaque vulnerability. We downloaded…”
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