Search Results - "Santos, Osvaldo dos"

Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition by Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Chen, Zecheng, Ayral-Kaloustian, Semiramis, Dos Santos, Osvaldo, Delos Santos, Efren, Curran, Kevin, Follettie, Max T, Diesl, Veronica, Lucas, Judy, Geng, Yi, DeJoy, Susan Quinn, Petersen, Rosanne, Chaudhary, Inder, Brooijmans, Natasja, Mansour, Tarek S, Arndt, Kim, Chen, Lei

“…We are introducing a novel series of 2,4-diaminoquinazolines as β-catenin/Tcf4 inhibitors which were identified by ligand-based design. Here we elucidate the…”
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Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179 by Chen, Zecheng, Venkatesan, Aranapakam M, Dos Santos, Osvaldo, Delos Santos, Efren, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Ashcroft, Joseph, McDonald, Leonard A, Mansour, Tarek S

“…The synthesis and stereochemical determination of…”
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Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor by MALLON, Robert, FELDBERG, Larry R, HOLLANDER, Irwin, LUCAS, Judy, CHAUDHARY, Inder, DEHNHARDT, Christoph, DELOS SANTOS, Efren, ZECHENG CHEN, DOS SANTOS, Osvaldo, AYRAL-KALOUSTIAN, Semiramis, VENKATESAN, Aranapakam

“…The aim of this study was to show preclinical efficacy and clinical development potential of PKI-587, a dual phosphoinositide 3-kinase (PI3K)/mTOR inhibitor…”
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Sulfonation and anticoagulant activity of botryosphaeran from Botryosphaeria rhodina MAMB-05 grown on fructose by Mendes, Simone Ferreira, Santos, Osvaldo dos, Barbosa, Aneli M., Vasconcelos, Ana Flora D., Aranda-Selverio, Gabriel, Monteiro, Nilson K., Dekker, Robert F.H., Pereira, Mariana Sá, Tovar, Ana Maria F., Mourão, Paulo A. de Souza, Silva, Maria de Lourdes Corradi da

“…Botryosphaeran (EPS FRU), an exopolysaccharide of the β-(1→3,1→6)- d-glucan type with 31% branching at C-6, is produced by the fungus Botryosphaeria rhodina…”
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Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor by Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, James, Abraham, Robert T, Chaudhary, Inder, Mansour, Tarek S

“…The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose metabolism. It has been recognized…”
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Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor by Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Soloveva, Veronica, Venkatesan, Aranapakam, Dehnhardt, Christoph, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Gibbons, Jay

“…PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-alpha mutants, and…”
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PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor by Venkatesan, Aranapakam M., Chen, Zecheng, Santos, Osvaldo Dos, Dehnhardt, Christoph, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Chaudhary, Inder, Mansour, Tarek S.

“…A series of mono-morpholino 1,3,5-triazine derivatives ( 8a– 8q) bearing a 3-oxa-8-azabicyclo[3.2.1]octane were prepared and evaluated for PI3-kinase/mTOR…”
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Overview of syphilis in a northern Brazilian city from 2013 to 2017 by NONATO, OSVALDO CAMPOS DOS SANTOS, Barbosa Martins, Raissa, Bezerra da Silva Sussuarana, Suzana, Albuquerque da Costa, Layra Lucy Maria

“…Justifications and Objectives: Syphilis is the most widespread bacterial infection in the human population, being the main form of transmission through sexual…”
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2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer by Chen, Zecheng, Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Santos, Osvaldo Dos, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Chen, Lei, Geng, Yi, Arndt, Kim T., Lucas, Judy, Chaudhary, Inder, Mansour, Tarek S.

“…The synthesis and SAR of a series of 2,4-diamino-quinazoline derivatives as β-catenin/Tcf-4 inhibitors are described. The synthesis and SAR of a series of…”
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Robotic process automation and artificial intelligence capabilities driving digital strategy: a resource-based view by Moderno, Osvaldo Braz dos Santos, Braz, Antonio Carlos, Nascimento, Paulo Tromboni de Souza

“…PurposeResearch of currently limited literature sees Robotic Process Automation (RPA) as an important tool at the tactical level. However, the literature has…”
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Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors:  Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates by Venkatesan, Aranapakam M, Gu, Yansong, Santos, Osvaldo Dos, Abe, Takao, Agarwal, Atul, Yang, Youjun, Petersen, Peter J, Weiss, William J, Mansour, Tarek S, Nukaga, Michiyoshi, Hujer, Andrea M, Bonomo, Robert A, Knox, James R

“…The design and synthesis of a series of seven tricyclic 6-methylidene penems as novel class A and C serine β-lactamase inhibitors is described. These compounds…”
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o ensino da matemática: memórias de educadores do grupo escolar dom romualdo de seixas (1960-1970) by Carvalho Moia, Romulo Everton de, Pessoa Chaves Rocha, Maria Lúcia, Santos Barros, Osvaldo dos

“…A pesquisa teve como objetivo descrever e analisar as práticas educativas no ensino da matemática nos anos iniciais da escolarização no Grupo Escolar Dom…”
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TRIATOMÍNEOS DE INSETÁRIO E PATOS UTILIZADOS COMO FONTE DE ALIMENTAÇÃO INFECTADOS COM BARTONELLA HENSELAE by dos Santos, Luciene Silva, dos Santos Nonato, Osvaldo Campos, Velho, Paulo Eduardo Neves Ferreira, Oliveira, Jader, da Rosa, João Aristeu, Drummond, Marina Rovani

“…As bartoneloses são doenças negligenciadas causadas por bactérias gram-negativas, fastidiosas e pertencentes ao gênero Bartonella. Estas bactérias têm uma…”
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COMPETÊNCIAS E DESEMPENHO DO VOLUNTARIADO HOSPITALAR: UM ESTUDO DE CASO by Czupriniaki, Débora Regina, PINHEIRO, OSVALDO DANIEL DOS SANTOS

“…As organizações são instigadas a buscar maior competitividade no mercado e o foco, a cada dia, volta-se para as pessoas e suas competências. O capital humano…”
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Synthesis and Cyclic Voltammetry Studies of Copper Complexes of Bromo- and Alkoxyphenyl-Substituted Derivatives of Tris(2-pyridylmethyl)amine:  Influence of Cation−Alkoxy Interactions on Copper Redox Potentials by Chuang, Chang-Lin, dos Santos, Osvaldo, Xu, Xiaodong, Canary, James W.

“…A combination of host−guest chemistry and coordination chemistry in the design of electrochemical sensors for alkali metal and ammonium ions is described. The…”
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O Whatsapp no apoio à resolução de problema de matrizes: um produto educacional na EJA by Reis, Michel Silva, Barros, Osvaldo dos Santos

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A Review of Intelligent Sensor-Based Systems for Pressure Ulcer Prevention by Silva, Arlindo, Metrôlho, José, Ribeiro, Fernando, Fidalgo, Filipe, Santos, Osvaldo, Dionisio, Rogério

“…Pressure ulcers are a critical issue not only for patients, decreasing their quality of life, but also for healthcare professionals, contributing to burnout…”
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Propriedades reológicas e efeito da adição de sal na viscosidade de exopolissacarídeos produzidos por bactérias do gênero Rhizobium by Aranda-Selverio, Gabriel, Penna, Ana Lúcia Barretto, Campos-Sás, Luciana Frizarin, Santos Junior, Osvaldo dos, Vasconcelos, Ana Flora Dalberto, Silva, Maria de Lourdes Corradi da, Lemos, Eliana Gertrudes Macedo, Campanharo, João Carlos, Silveira, Joana Léa Meira

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ESCOLA, TRABALHO INFANTIL E A PRECARIZAÇÃO DA INFÂNCIA COMO TEMPO DE FORMAÇÃO by Machado, Osvaldo dos Santos, Rodrigues, Doriedson do Socorro, Freitas, Neylce Furtado, Pantoja, Eder de Jesus de Sousa, Pinheiro, Vanderlei Maciel

“…Neste trabalho, problematizamos o trabalho infantil como negação ao tempo da infância e ao direito aos tempos-espaços dos processos formativos para a classe…”
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O Whatsapp no apoio à resolução de problema de matrizes: um produto educacional na EJA by Michel Silva Reis, Osvaldo dos Santos Barros

“…Este artigo traz uma reflexão do produto educacional de minha prática docente e derivada da dissertação de mestrado profissional, onde apresentamos um livro…”
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