Bilateral proliferative retinopathy as the initial presentation of chronic myeloid leukemia

The authors report a rare case of a 48-year-old male with chronic myeloid leukemia (CML) who initially presented with a bilateral proliferative retinopathy. The patient complained of recent visual loss and floaters in both eyes (BE). Ophthalmologic evaluation revealed a best corrected visual acuity...

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Bibliographic Details
Published in:	Middle East African journal of ophthalmology Vol. 20; no. 4; pp. 353 - 356
Main Authors:	Macedo, Mafalda S F, Figueiredo, Ana R M, Ferreira, Natália N, Barbosa, Irene M A, Furtado, Maria João F B S, Correia, Nuno F C B A, Gomes, Miguel P, Lume, Miguel R B, Menéres, Maria João S, Santos, Marinho M N, Meireles, M Angelina C S
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-10-2013 Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd
Subjects:	Allopurinol Allopurinol - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Benzamides - administration & dosage Bone marrow Care and treatment Case Report Chromosomes, Human, Pair 22 - genetics Chromosomes, Human, Pair 9 - genetics Chronic myeloid leukemia Combined Modality Therapy Complications and side effects Diagnosis Dosage and administration Drug therapy Fluorescein Angiography Humans Hydroxyurea Hydroxyurea - administration & dosage Hypertension Imatinib Mesylate Laser Coagulation Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Male Medical imaging Methods Middle Aged Ophthalmology Patients Piperazines - administration & dosage Proteins Pyrimidines - administration & dosage Retinal diseases Retinal Neovascularization - diagnosis Retinal Neovascularization - genetics Retinal Neovascularization - therapy Rodents Translocation, Genetic - genetics Visual Acuity - physiology Vitrectomy Hyperviscosity Syndrome Proliferative Retinopathy Chronic Myeloid Leukemia
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Summary:	The authors report a rare case of a 48-year-old male with chronic myeloid leukemia (CML) who initially presented with a bilateral proliferative retinopathy. The patient complained of recent visual loss and floaters in both eyes (BE). Ophthalmologic evaluation revealed a best corrected visual acuity (BCVA) of 20/50 in the right eye and 20/200 in the left eye (LE). Fundoscopy showed the presence of bilateral peripheral capillary dropout with multiple retinal sea fan neovascularisations, which were confirmed on fluorescein angiography. Full blood count revealed hyperleukocytosis, thrombocytosis, anemia, and hyperuricemia. Bone marrow aspiration and biopsy showed the reciprocal chromosomal translocation t (9;22), diagnostic of CML. The patient was started on hydroxyurea, allopurinol and imatinib mesylate. He received bilateral panretinal laser photocoagulation and a vitrectomy was performed in the LE. The patient has been in complete hematologic, cytogenetic, and major molecular remission while on imatinib and his BCVA is 20/25 in BE.
ISSN:	0974-9233 0975-1599 0975-1599 0974-9233
DOI:	10.4103/0974-9233.120016