Search Results - "Santos, Mariana Silva dos"
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1
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Published in Nature communications (06-06-2019)“…Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms…”
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2
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Published in Science (American Association for the Advancement of Science) (28-06-2019)“…Tuberculosis, caused by the intracellular pathogen , remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of…”
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3
Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells
Published in Nature communications (15-01-2021)“…Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are…”
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4
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1
Published in Nature communications (26-10-2023)“…Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA -deficient breast, ovarian and prostate cancers. As their efficacy is…”
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5
Paraquat-loaded alginate/chitosan nanoparticles: Preparation, characterization and soil sorption studies
Published in Journal of hazardous materials (15-06-2011)“…Agrochemicals are amongst the contaminants most widely encountered in surface and subterranean hydrological systems. They comprise a variety of molecules, with…”
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6
Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes
Published in Molecular systems biology (01-08-2018)“…Circadian rhythms are cell‐autonomous biological oscillations with a period of about 24 h. Current models propose that transcriptional feedback loops are the…”
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7
MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
Published in Nature chemical biology (01-11-2018)“…α-Ketoglutarate (αKG) is a key node in many important metabolic pathways. The αKG analog N-oxalylglycine (NOG) and its cell-permeable prodrug…”
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8
Hypoxic and Reoxygenated Microenvironment: Stemness and Differentiation State in Glioblastoma
Published in Molecular neurobiology (01-10-2017)“…Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. Hypoxia is a distinct feature in GBM and plays a significant role…”
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9
OXIDATIVE AND MICROBIOLOGICAL STABILITY OF FRESH PORK SAUSAGE WITH ADDED SUN MUSHROOM POWDER
Published in Ciência e agrotecnologia (01-08-2015)“…Consumers are becoming more aware of the toxicological implications of artificial additives in foods. Natural antioxidants, in addition to reducing the…”
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10
Improved canine and human visceral leishmaniasis immunodiagnosis using combinations of synthetic peptides in enzyme-linked immunosorbent assay
Published in PLoS neglected tropical diseases (01-05-2012)“…Zoonotic visceral leishmaniasis (VL) is a severe infectious disease caused by protozoan parasites of the genus Leishmania and the domestic dogs are the main…”
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11
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors
Published in Science (American Association for the Advancement of Science) (09-04-2021)“…Mutations in the or tumor suppressor genes predispose individuals to breast and ovarian cancer. In the clinic, these cancers are treated with inhibitors that…”
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12
The impacts of abnormal color vision on people’s life: an integrative review
Published in Quality of life research (01-04-2019)“…Background This article shows an integrative review on the impact that abnormal color vision may have on the daily routine of individuals. Purpose We followed…”
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13
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
Published in Nature communications (28-11-2022)“…Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal…”
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14
Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
Published in Developmental cell (22-05-2023)“…Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In the adult brain, NSCs are…”
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15
Collagen quantification in rabbit dermal wounds treated with heterologous platelet-rich plasma gel
Published in Semina. Ciências agrárias : revista cultural e científica da Universidade Estadual de Londrina (01-01-2017)“…Platelet-rich plasma (PRP) has been extensively studied as a biomaterial for wound treatment, and the heterologous PRP is usefulin the event that obtaining the…”
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16
Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
Published in Nature chemical biology (01-12-2019)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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17
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer
Published in Nature metabolism (01-11-2023)“…Tumors are intrinsically heterogeneous and it is well established that this directs their evolution, hinders their classification and frustrates therapy 1 – 3…”
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18
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine
Published in Communications biology (26-08-2022)“…α-ketoglutarate (αKG) is a central metabolic node with a broad influence on cellular physiology. The αKG analogue N -oxalylglycine (NOG) and its…”
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19
Publisher Correction: MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine
Published in Communications biology (27-09-2022)Get full text
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20
Stability of vacuum-packed meat from finishing steers fed different inclusion levels of brewer's spent grain
Published in Meat science (01-01-2019)“…Brewer's spent grain (BSG) as a partial substitute for corn silage (CS) was evaluated in finishing feedlot steers on the lipid, protein, color, and…”
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