Search Results - "Santos, Lúcio Lara"

Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks by Peixoto, Andreia, Relvas-Santos, Marta, Azevedo, Rita, Santos, Lúcio Lara, Ferreira, José Alexandre

“…Decades of research have disclosed a plethora of alterations in protein glycosylation that decisively impact in all stages of disease and ultimately contribute…”
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Treatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report by Santos, Lúcio Lara, Oliveira, Júlio, Monteiro, Eurico, Santos, Juliana, Sarmento, Cristina

“…Advanced head and neck squamous cell carcinoma, after locoregional treatment and multiple lines of systemic therapies, represents a great challenge to overcome…”
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Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation by Ferreira, José Alexandre, Peixoto, Andreia, Neves, Manuel, Gaiteiro, Cristiana, Reis, Celso A, Assaraf, Yehuda G, Santos, Lúcio Lara

“…Abstract Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based…”
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Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics by Ferreira, José Alexandre, Magalhães, Ana, Gomes, Joana, Peixoto, Andreia, Gaiteiro, Cristiana, Fernandes, Elisabete, Santos, Lúcio Lara, Reis, Celso A

“…Highlights • Alterations in glycosylation are hallmarks of malignant transformation in the gastric and colorectal tract. • Altered protein glycosylation favors…”
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A roadmap for translational cancer glycoimmunology at single cell resolution by Peixoto, Andreia, Miranda, Andreia, Santos, Lúcio Lara, Ferreira, José Alexandre

“…Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints. Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and…”
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Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival by Poças, Juliana, Marques, Catarina, Gomes, Catarina, Otake, Andreia Hanada, Pinto, Filipe, Ferreira, Mariana, Silva, Tiago, Faria-Ramos, Isabel, Matos, Rita, Ribeiro, Ana Raquel, Senra, Emanuel, Cavadas, Bruno, Batista, Sílvia, Maia, Joana, Macedo, Joana A, Lima, Luís, Afonso, Luís Pedro, Ferreira, José Alexandre, Santos, Lúcio Lara, Polónia, António, Osório, Hugo, Belting, Mattias, Reis, Celso A, Costa-Silva, Bruno, Magalhães, Ana

“…Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane…”
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Targeted and Self-Adjuvated Nanoglycovaccine Candidate for Cancer Immunotherapy by Freitas, Rui, Ferreira, Eduardo, Miranda, Andreia, Ferreira, Dylan, Relvas-Santos, Marta, Castro, Flávia, Santos, Beatriz, Gonçalves, Martina, Quintas, Sofia, Peixoto, Andreia, Palmeira, Carlos, Silva, André M. N., Santos, Lúcio Lara, Oliveira, Maria José, Sarmento, Bruno, Ferreira, José Alexandre

“…Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific…”
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Synthesis and Optimization of Lectin Functionalized Nanoprobes for the Selective Recovery of Glycoproteins from Human Body Fluids by Ferreira, José A, Daniel-da-Silva, Ana Luísa, Alves, Renato M. P, Duarte, Daniel, Vieira, Igor, Santos, Lúcio Lara, Vitorino, Rui, Amado, Francisco

“…Biomedical sciences, and in particular biomarker research, demand efficient glycoprotein enrichment platforms. Herein magnetic nanoprobes (MNP), after being…”
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Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology by Fernandes, Elisabete, Sores, Janine, Cotton, Sofia, Peixoto, Andreia, Ferreira, Dylan, Freitas, Rui, Reis, Celso A, Santos, Lúcio Lara, Ferreira, José Alexandre

“…Esophageal (OC), gastric (GC) and colorectal (CRC) cancers are amongst the digestive track tumors with higher incidence and mortality due to significant…”
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Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review by Pereira, Francisca, Domingues, M Rosário, Vitorino, Rui, Guerra, Inês M S, Santos, Lúcio Lara, Ferreira, José Alexandre, Ferreira, Rita

“…Bladder cancer (BCa) research relying on Omics approaches has increased over the last few decades, improving the understanding of BCa pathology and…”
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Target Score-A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness by Cotton, Sofia, Ferreira, Dylan, Soares, Janine, Peixoto, Andreia, Relvas-Santos, Marta, Azevedo, Rita, Piairo, Paulina, Diéguez, Lorena, Palmeira, Carlos, Lima, Luís, Silva, André M N, Lara Santos, Lúcio, Ferreira, José Alexandre

“…Esophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly…”
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On the predictability of postoperative complications for cancer patients: a Portuguese cohort study by Gonçalves, Daniel, Henriques, Rui, Santos, Lúcio Lara, Costa, Rafael S

“…Abstract Postoperative complications are still hard to predict despite the efforts towards the creation of clinical risk scores. The published scores…”
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Neoadjuvant Gastric Cancer Treatment and Associated Nutritional Critical Domains for the Optimization of Care Pathways: A Systematic Review by Correia, Marta, Moreira, Ines, Cabral, Sonia, Castro, Carolina, Cruz, Andreia, Magalhães, Bruno, Santos, Lúcio Lara, Irving, Susana Couto

“…(1) Background: Gastric cancer patients are known to be at a high risk of malnutrition, sarcopenia, and cachexia, and the latter impairs the patient's…”
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Targeted O‐glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced‐stage bladder tumours by Cotton, Sofia, Azevedo, Rita, Gaiteiro, Cristiana, Ferreira, Dylan, Lima, Luís, Peixoto, Andreia, Fernandes, Elisabete, Neves, Manuel, Neves, Diogo, Amaro, Teresina, Cruz, Ricardo, Tavares, Ana, Rangel, Maria, Silva, André M. N., Santos, Lúcio Lara, Ferreira, José Alexandre

“…Bladder carcinogenesis and tumour progression is accompanied by profound alterations in protein glycosylation on the cell surface, which may be explored for…”
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Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion by Gaiteiro, Cristiana, Soares, Janine, Relvas-Santos, Marta, Peixoto, Andreia, Ferreira, Dylan, Paulo, Paula, Brandão, Andreia, Fernandes, Elisabete, Azevedo, Rita, Palmeira, Carlos, Freitas, Rui, Miranda, Andreia, Osório, Hugo, Prieto, Jesús, Lima, Luís, Silva, André M N, Santos, Lúcio Lara, Ferreira, José Alexandre

“…Bladder cancer (BC) management demands the introduction of novel molecular targets for precision medicine. Cell surface glycoprotein CD44 has been widely…”
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Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids by Loureiro, Liliana R., Sousa, Diana P., Ferreira, Dylan, Chai, Wengang, Lima, Luís, Pereira, Carina, Lopes, Carla B., Correia, Viviana G., Silva, Lisete M., Li, Chunxia, Santos, Lúcio Lara, Ferreira, José Alexandre, Barbas, Ana, Palma, Angelina S., Novo, Carlos, Videira, Paula A.

“…Incomplete O -glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen…”
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Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer by Soares, Janine, Eiras, Mariana, Ferreira, Dylan, Santos, Daniela A R, Relvas-Santos, Marta, Santos, Beatriz, Gonçalves, Martina, Ferreira, Eduardo, Vieira, Renata, Afonso, Luís Pedro, Santos, Lúcio Lara, Dinis-Ribeiro, Mário, Lima, Luís, Ferreira, José Alexandre

“…Colorectal cancer (CRC) screening relies primarily on stool analysis to identify occult blood. However, its sensitivity for detecting precancerous lesions is…”
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A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway by Freitas, Micaela, Ferreira, Fábio, Carvalho, Sónia, Silva, Fernanda, Lopes, Paula, Antunes, Luís, Salta, Sofia, Diniz, Francisca, Santos, Lúcio Lara, Videira, José Flávio, Henrique, Rui, Jerónimo, Carmen

“…Colorectal cancer (CRC) is one of the most incident cancers, associated with significant morbidity and mortality, and usually classified into three main…”
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Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer by Ferreira, Eduardo, Ferreira, Dylan, Relvas-Santos, Marta, Freitas, Rui, Soares, Janine, Azevedo, Rita, Afonso, Luís Pedro, Lima, Luís, Santos, Beatriz, Gonçalves, Martina, Silva, André M N, Santos, Lúcio Lara, Peixoto, Andreia, Ferreira, José Alexandre

“…Muscle-invasive bladder cancer (MIBC) remains a pressing health concern due to conventional treatment failure and significant molecular heterogeneity,…”
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Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells by Fernandes, Elisabete, Freitas, Rui, Ferreira, Dylan, Soares, Janine, Azevedo, Rita, Gaiteiro, Cristiana, Peixoto, Andreia, Oliveira, Sara, Cotton, Sofia, Relvas-Santos, Marta, Afonso, Luis Pedro, Palmeira, Carlos, Oliveira, Maria José, Ferreira, Rita, Silva, André M N, Lara Santos, Lúcio, Ferreira, José Alexandre

“…Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for…”
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