Search Results - "Santos, Jéssica Cristina"
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Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis
Published in PLoS neglected tropical diseases (01-02-2020)“…Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by…”
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Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives
Published in Clinical & translational immunology (2020)“…COVID‐19 is a severe health problem in many countries and has altered day‐to‐day life in the whole world. This infection is caused by the SARS‐CoV‐2 virus, and…”
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Trained immunity: adaptation within innate immune mechanisms
Published in Physiological reviews (01-01-2023)“…The mechanisms underlying innate immune memory have been extensively explored in the last decades but are in fact largely unknown. Although the specificity of…”
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Immunotherapeutic Potential of Interleukin-32 and Trained Immunity for Leishmaniasis Treatment
Published in Trends in parasitology (01-02-2021)“…Neglected tropical diseases annually account for several million infections worldwide. Efficacious treatment for these poorly understood infectious diseases is…”
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The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors
Published in Neurotherapeutics (01-01-2022)“…Chemotherapy-induced peripheral neuropathy (CIPN) is the main dose-limiting adverse effect of chemotherapy drugs such as paclitaxel (PTX). PTX causes marked…”
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Interleukin 32: a novel player in the control of infectious diseases
Published in Journal of leukocyte biology (01-01-2017)“…Interleukin 32 (IL‐32) is a proinflammatory cytokine, expressed as 9 distinct isoforms. The most active isoform is the predominantly intracellular‐functioning…”
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Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes
Published in Atherosclerosis (01-04-2018)“…The role of interleukin (IL-)32 in inflammatory conditions is well-established, however, the mechanism behind its role in atherosclerosis remains unexplained…”
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β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32
Published in Cell reports (Cambridge) (03-09-2019)“…American tegumentary leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoans. Innate immune cells undergo long-term functional…”
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Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice
Published in Infection and immunity (01-05-2018)“…Visceral leishmaniasis (VL) is a chronic parasitic disease caused by in the Americas. During VL, several proinflammatory cytokines are produced in spleen,…”
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The NOD2 receptor is crucial for immune responses towards New World Leishmania species
Published in Scientific reports (09-11-2017)“…American Tegumentary Leishmaniasis is a chronic infection caused by Leishmania protozoan. It is not known whether genetic variances in NOD-like receptor (NLR)…”
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Genomic study of the resilience of buffalo cows to a negative energy balance
Published in Journal of applied genetics (01-05-2022)“…The research article was carried out with the objective of studying the genetic variation on the resilience of buffaloes to negative energy balance—NEB…”
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IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
Published in BMC medicine (16-11-2021)“…Background Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are…”
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Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity
Published in Cell reports (Cambridge) (26-03-2024)“…Innate immune cells can undergo long-term functional reprogramming after certain infections, a process called trained immunity (TI). Here, we focus on antigens…”
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Analysis of the population structure of buffaloes in Brazil
Published in Tropical animal health and production (01-11-2020)“…The aim of this study was to evaluate the population structure of Brazilian buffaloes using of pedigree information. The pedigree used in the analyses included…”
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Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species
Published in PLoS neglected tropical diseases (27-02-2017)“…Interleukin-32 (IL-32) is expressed in lesions of patients with American Tegumentary Leishmaniasis (ATL), but its precise role in the disease remains unknown…”
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High-throughput proteomic analysis reveals systemic dysregulation in virally suppressed people living with HIV
Published in JCI insight (08-06-2023)“…BACKGROUNDPeople living with HIV (PLHIV) receiving antiretroviral therapy (ART) exhibit persistent immune dysregulation and microbial dysbiosis, leading to…”
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IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
Published in Parasites & vectors (14-07-2017)“…Interleukin 32 (IL-32) is a pro-inflammatory cytokine induced in patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis…”
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Genome-Wide Association Study Reveals CLEC7A and PROM1 as Potential Regulators of Paracoccidioides brasiliensis -Induction of Cytokine Production in Peripheral Blood Mononuclear Cells
Published in Journal of fungi (Basel) (30-03-2023)“…Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus and the different clinical forms of the disease are associated with the host…”
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Behavioral and cardiorespiratory responses to bilateral microinjections of oxytocin into the central nucleus of amygdala of Wistar rats, an experimental model of compulsion
Published in PloS one (18-07-2014)“…The central nucleus of amygdala plays an important role mediating fear and anxiety responses. It is known that oxytocin microinjections into the central…”
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Targeted plasma proteomics identifies MICA and IL1R1 proteins associated with HIV-1 reservoir size
Published in iScience (21-04-2023)“…HIV-1 reservoir shows high variability in size and activity among virally suppressed individuals. Differences in the size of the viral reservoir may relate to…”
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