Search Results - "Santos, Gema Sanz"
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Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity
Published in Cancer discovery (01-12-2021)“…The repression of repetitive elements is an important facet of p53's function as a guardian of the genome. Paradoxically, we found that p53 activated by MDM2…”
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Journal Article -
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Identification and targeting of selective vulnerability rendered by tamoxifen resistance
Published in Breast cancer research : BCR (29-07-2020)“…Background The estrogen receptor (ER)-positive breast cancer represents over 80% of all breast cancer cases. Even though adjuvant hormone therapy with…”
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Journal Article -
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Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
Published in British journal of cancer (23-11-2022)“…Background p53 mutants contribute to the chronic inflammatory tumour microenvironment (TME). In this study, we address the mechanism of how p53 mutants lead to…”
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Gene expression pattern in swine neutrophils after lipopolysaccharide exposure: a time course comparison
Published in BMC proceedings (03-06-2011)“…Experimental exposure of swine neutrophils to bacterial lipopolysaccharide (LPS) represents a model to study the innate immune response during bacterial…”
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Journal Article