Search Results - "Santos, Fátima M"
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Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases
Published in Frontiers in immunology (16-02-2023)“…Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are leading causes of visual impairment and blindness in people aged 50 years or older in…”
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2
Proteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: Mechanisms of endothelial dysfunction in chronic kidney disease
Published in Life sciences (1973) (15-08-2024)“…Cardiovascular pathology is the main cause of death in chronic kidney disease (CKD) patients. CKD is associated with the accumulation of uremic toxins in the…”
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3
Proteome analysis of vitreous humor in retinal detachment using two different flow-charts for protein fractionation
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-09-2017)“…•Two fractionation strategies were proposed for the vitreous proteome analysis in retinal detachment.•A total of 127 proteins were identified in vitreous of…”
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4
VEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases and Its Correlation with Structural Parameters
Published in Medical sciences (Basel) (09-08-2017)“…Vascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. The knowledge gap about VEGF-B expression and how its levels…”
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5
Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer
Published in International journal of nanomedicine (01-01-2012)“…Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid) and surface-functionalized with anticarcinoembryonic antigen…”
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6
Venomic and pharmacological activity of Acanthoscurria paulensis (Theraphosidae) spider venom
Published in Toxicon (Oxford) (01-01-2013)“…In the present study we conducted proteomic and pharmacological characterizations of the venom extracted from the Brazilian tarantula Acanthoscurria paulensis,…”
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7
The protective effects of nutritional antioxidant therapy on Ehrlich solid tumor-bearing mice depend on the type of antioxidant therapy chosen: histology, genotoxicity and hematology evaluations
Published in The Journal of nutritional biochemistry (01-11-2011)“…Strong evidence indicates that reactive oxygen species (ROS) play an important role in the initiation as well as the promotion phase of carcinogenesis. Studies…”
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The use of physical and virtual infrastructures for the validation of algal cryopreservation methods in international culture collections
Published in Cryo-Letters (01-09-2007)“…Two cryopreservation methods, colligative cryoprotection coupled with controlled cooling and vitrification-based, encapsulation-dehydration were validated by…”
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9
Refinement of two-dimensional electrophoresis for vitreous proteome profiling using an artificial neural network
Published in Analytical and bioanalytical chemistry (01-08-2019)“…Despite technological advances, two-dimensional electrophoresis (2DE) of biological fluids, such as vitreous, remains a major challenge. In this study,…”
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10
Trends in protein-based biosensor assemblies for drug screening and pharmaceutical kinetic studies
Published in Molecules (18-08-2014)“…The selection of natural and chemical compounds for potential applications in new pharmaceutical formulations constitutes a time-consuming procedure in drug…”
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Trends in proteomic analysis of human vitreous humor samples
Published in Electrophoresis (01-09-2014)“…Proteomic analysis of human vitreous humor (VH) may elucidate the pathogenesis of retinal ocular diseases and may provide information for the development of…”
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12
Biosynthesis and purification of histidine-tagged human soluble catechol-O-methyltransferase
Published in Journal of chemical technology and biotechnology (1986) (01-12-2016)“…BACKGROUND Catechol‐O‐methyltransferase (COMT, EC 2.1.1.6) has been implicated in several human diseases including Parkinson's disease and the most…”
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13
Vitreous humor in the pathologic scope: Insights from proteomic approaches
Published in Proteomics. Clinical applications (01-02-2015)“…The vitreous humor (VH) is the largest component of the eye. It is a colorless, gelatinous, highly hydrated matrix that fills the posterior segment of the eye…”
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14
Metformin (dimethyl-biguanide) induced DNA damage in mammalian cells
Published in Genetics and molecular biology (01-01-2012)“…Metformin (dimethyl-biguanide) is an insulin-sensitizing agent that lowers fasting plasma-insulin concentration, wherefore it's wide use for patients with a…”
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15
Anti-CEA tagged iron nanoparticles for targeting triple-negative breast cancer
Published in Biomedical materials (Bristol) (01-05-2021)“…Systemic therapy is generally required for breast cancer. However, treatment toxicity and side effects are a concern, especially for triple-negative breast…”
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Ultrastructural study of Haematococcus lacustris (Girod.) Rostafinski (Volvocales). I. Some aspects of carotenogenesis
Published in CYTOLOGIA (1984)“…The process of accumulation of secondary carotenoids (astaxanthin) in Haematococcus lacustris was analysed in the optical and electron microscopes. The more…”
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Bracken-fern extracts can be clastogenic or aneugenic depending on the tissue cell assay
Published in Food and chemical toxicology (01-11-2006)“…The consumption of bracken fern ( Pteridium aquilinum) as food is associated with a high incidence of cancer in humans and animals. We investigated the…”
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Interaction of bracken-fern extract with vitamin C in human submandibular gland and oral epithelium cell lines
Published in Mutation research (30-04-2008)“…he consumption of bracken-fern ( Pteridium aquilinum) as food is associated with a high incidence of cancer in humans and animals. Thus far, the carcinogenic…”
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Autonomia municipal e a gestão das políticas educacionais a partir da lógica dos sistemas de ensino: perspectivas de criação e implantação no estado do Pará
Published in Perspectiva (Florianópolis, Brazil) (28-05-2012)“…Este estudo traça um panorama sobre o processo de criação e implantação dos sistemas municipais de ensino no Brasil e, particularmente, no Estado do Pará,…”
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Ultrastructural Study of Haematococcus lacustris (Girod.) Rostafinski (Volvocales) II: Mitosis and cytokinesis
Published in CYTOLOGIA (1984)“…In this article are presented the results of the ultrastructural study of the cell division in Haematococcus lacustris. The more significative data are as…”
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