Search Results - "Santos, Clementina M. M."

The antioxidant activity of prenylflavonoids by Santos, Clementina, Silva, Artur

“…Prenylated flavonoids combine the flavonoid moiety and the lipophilic prenyl side-chain. A great number of derivatives belonging to the class of chalcones,…”
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Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications by Albuquerque, Hélio M T, Santos, Clementina M M, Silva, Artur M S

“…This review reports on the latest developments (since 2014) in the chemistry of cholesterol and its applications in different research fields. These…”
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Synthesis of Chromone-Related Pyrazole Compounds by Santos, Clementina M M, Silva, Vera L M, Silva, Artur M S

“…Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of…”
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2,3-Diarylxanthones as Potential Inhibitors of Arachidonic Acid Metabolic Pathways by Santos, Clementina M. M., Ribeiro, Daniela, Silva, Artur M. S., Fernandes, Eduarda

“…In response to an inflammatory stimulus, arachidonic acid (AA), the main polyunsaturated fatty acid present in the phospholipid layer of cell membranes, is…”
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A comprehensive review on xanthone derivatives as α-glucosidase inhibitors by Santos, Clementina M.M., Freitas, Marisa, Fernandes, Eduarda

“…α-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and…”
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2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study by Santos, Clementina M.M., Freitas, Marisa, Ribeiro, Daniela, Gomes, Ana, Silva, Artur M.S., Cavaleiro, José A.S., Fernandes, Eduarda

“…Several 2,3-diarylxanthones were tested for their scavenging activity for ROS (O2·-, H2O2, 1O2, HOCl and ROO) and RNS (NO and ONOO−). Structure–activity…”
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Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways by Gomes, Ana, Fernandes, Eduarda, Silva, Artur M.S., Pinto, Diana C.G.A., Santos, Clementina M.M., Cavaleiro, José A.S., Lima, José L.F.C.

“…Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly…”
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Transition Metal‐Catalyzed Transformations of Chalcones by Santos, Clementina M. M., Silva, Artur M. S.

“…Chalcones are a class of naturally occurring flavonoid compounds associated to a variety of biological and pharmacological properties. Several reviews have…”
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Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity by Gomes, Ana, Fernandes, Eduarda, Garcia, M. Beatriz Q., Silva, Artur M.S., Pinto, Diana C.G.A., Santos, Clementina M.M., Cavaleiro, José A.S., Lima, José L.F.C.

“…The scavenging effects of the studied 2-styrylchromones are related to their electrochemical behaviour. Our cyclic voltammetry results suggest an oxidation…”
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Characterization of 2,3-diarylxanthones by electrospray mass spectrometry: gas-phase chemistry versus known antioxidant activity properties by Silva, Eduarda M. P., Barros, Cristina M. R. F., Santos, Clementina M. M., Barros, António S., Domingues, M. Rosário M., Silva, Artur M. S.

“…Rationale Xanthones (XH) are a class of heterocyclic compounds widely distributed in nature that hold numerous noteworthy biological and antioxidant…”
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An Overview of 2‐Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties by Santos, Clementina M. M., Silva, Artur M. S.

“…2‐Styrylchromones are a small class of oxygen‐containing heterocycles. Despite their sparse occurrence in nature, several synthetic approaches have been…”
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2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species by Gomes, Ana, Fernandes, Eduarda, Silva, Artur M.S., Santos, Clementina M.M., Pinto, Diana C.G.A., Cavaleiro, José A.S., Lima, José L.F.C.

“…2-Styrylchromones were tested for their scavenging activity against ROS and RNS. Some of the studied compounds proved to be extremely efficient scavengers of…”
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A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives by Rocha, Sónia, Sousa, Adelaide, Ribeiro, Daniela, Correia, Catarina M, Silva, Vera L M, Santos, Clementina M M, Silva, Artur M S, Araújo, Alberto N, Fernandes, Eduarda, Freitas, Marisa

“…The inhibition of carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase, is one of the major therapeutic strategies for the treatment of type 2…”
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Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities by Proença, Carina, Albuquerque, Hélio M.T., Ribeiro, Daniela, Freitas, Marisa, Santos, Clementina M.M., Silva, Artur M.S., Fernandes, Eduarda

“…Chromones and xanthones are oxygen-containing heterocyclic compounds acknowledged by their antioxidant properties. In an effort to develop novel agents with…”
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2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus by Santos, Clementina, Proença, Carina, Freitas, Marisa, Araújo, Alberto N., Silva, Artur M. S., Fernandes, Eduarda

“…alpha-amylase and alpha-glucosidase are key enzymes implicated in carbohydrate digestion and their inhibition has been suggested as a powerful approach for…”
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Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes by Albuquerque, Hélio M. T., Nunes da Silva, Raquel, Pereira, Marisa, Maia, André, Guieu, Samuel, Soares, Ana Raquel, Santos, Clementina M. M., Vieira, Sandra I., Silva, Artur M. S.

“…Reversing protein aggregation within cells may be an important tool to fight protein-misfolding disorders such as Alzheimer’s, Parkinson’s, and cardiovascular…”
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Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes by Fernandes, Eduarda, Carvalho, Márcia, Carvalho, Félix, Silva, Artur, Santos, Clementina, Pinto, Diana, Cavaleiro, José, Bastos, Maria de Lourdes

“…2-Styrylchromones are a novel class of chromones, vinylogues of flavones (2-phenylchromones), which have recently been found in nature. The best described…”
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1,6‐Conjugate Additions of Carbon Nucleophiles to 2‐[(1E,3E)‐4‐Arylbuta‐1,3‐dien‐1‐yl]‐4H‐chromen‐4‐ones by Albuquerque, Hélio M. T., Santos, Clementina M. M., Balanay, Mannix P., Cavaleiro, José A. S., Silva, Artur M. S.

“…The 1,6‐conjugate addition of nitromethane to 2‐[(1E,3E)‐4‐arylbuta‐1,3‐dien‐1‐yl]‐4H‐chromen‐4‐ones was accomplished and led mainly to the corresponding…”
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(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads by Albuquerque, Hélio M. T., Santos, Clementina M. M., Cavaleiro, José A. S., Silva, Artur M. S.

“…Xanthone‐1,2,3‐triazole dyads have been synthesized by two different approaches, both starting from novel (E)‐2‐(4‐arylbut‐1‐en‐3‐yn‐1‐yl)chromones, prepared…”
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2‐[(1E,3E)‐4‐Arylbuta‐1,3‐dien‐1‐yl]‐4H‐chromen‐4‐ones as Dienes in Diels–Alder Reactions – Experimental and Computational Studies by Albuquerque, Hélio M. T., Santos, Clementina M. M., Lima, Carlos F. R. A. C., Santos, Luís M. N. B. F., Cavaleiro, José A. S., Silva, Artur M. S.

“…The synthesis and reactivity of 2‐[(1E,3E)‐4‐arylbuta‐1,3‐dien‐1‐yl]‐4H‐chromen‐4‐ones as dienes in Diels–Alder (DA) reactions with several electron‐poor and…”
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