Search Results - "Santos, Charlene M"

Gulp1 is associated with the pharmacokinetics of PEGylated liposomal doxorubicin (PLD) in inbred mouse strains by Song, Gina, PharmD, PhD, Suzuki, Oscar T., PhD, Santos, Charlene M., RLATG, Lucas, Andrew T., PharmD, Wiltshire, Tim, PhD, Zamboni, William C., PharmD, PhD

“…Abstract Nanoparticles (NP) including liposomes are cleared by phagocytes of the mononuclear phagocyte system. High inter-patient variability in…”
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Minibeam radiation therapy enhanced tumor delivery of PEGylated liposomal doxorubicin in a triple-negative breast cancer mouse model by Price, Lauren S.L., Rivera, Judith N., Madden, Andrew J., Herity, Leah B., Piscitelli, Joseph A., Mageau, Savannah, Santos, Charlene M., Roques, Jose R., Midkiff, Bentley, Feinberg, Nana N., Darr, David, Chang, Sha X., Zamboni, William C.

“…Background: Minibeam radiation therapy is an experimental radiation therapy utilizing an array of parallel submillimeter planar X-ray beams. In preclinical…”
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Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer by Song, Gina, PhD, Tarrant, Teresa K., MD, White, Taylor F., PharmD, Barrow, David A., PhD, Santos, Charlene M., RLATG, Timoshchenko, Roman G., BS, Hanna, Suzan K., BS, Ramanathan, Ramesh K., MD, Lee, Craig R., PhD, Bae-Jump, Victoria L., MD, Gehrig, Paola A., MD, Zamboni, William C., PhD

“…Abstract Nanoparticles (NPs) are cleared by monocytes and macrophages. Chemokines CCL2 and CCL5 are key mediators for recruitment of these immune cells into…”
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GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer by Bevill, Samantha M, Olivares-Quintero, Jose F, Sciaky, Noah, Golitz, Brian T, Singh, Darshan, Beltran, Adriana S, Rashid, Naim U, Stuhlmiller, Timothy J, Hale, Andrew, Moorman, Nathaniel J, Santos, Charlene M, Angus, Steven P, Zawistowski, Jon S, Johnson, Gary L

“…Screening of an inhibitor library targeting kinases and epigenetic regulators identified several molecules having antiproliferative synergy with extraterminal…”
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Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models by Song, Gina, Darr, David B, Santos, Charlene M, Ross, Mark, Valdivia, Alain, Jordan, Jamie L, Midkiff, Bentley R, Cohen, Stephanie, Nikolaishvili-Feinberg, Nana, Miller, C Ryan, Tarrant, Teresa K, Rogers, Arlin B, Dudley, Andrew C, Perou, Charles M, Zamboni, William C

“…Tumor cells are surrounded by a complex microenvironment. The purpose of our study was to evaluate the role of heterogeneity of the tumor microenvironment in…”
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Genome-wide cancer-specific chromatin accessibility patterns derived from archival processed xenograft tumors by Marcel, Shelsa S, Quimby, Austin L, Noel, Melodie P, Jaimes, Oscar C, Mehrab-Mohseni, Marjan, Ashur, Suud A, Velasco, Brian, Tsuruta, James K, Kasoji, Sandeep K, Santos, Charlene M, Dayton, Paul A, Parker, Joel S, Davis, Ian J, Pattenden, Samantha G

“…Chromatin accessibility states that influence gene expression and other nuclear processes can be altered in disease. The constellation of transcription factors…”
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A sensitive high performance liquid chromatography assay for the quantification of doxorubicin associated with DNA in tumor and tissues by Lucas, Andrew T., O’Neal, Sara K., Santos, Charlene M., White, Taylor F., Zamboni, William C.

“…[Display omitted] •A HPLC method was validated to quantify doxorubicin associated to DNA from tissue.•Successfully applied to an in vivo mouse-based…”
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Profiling the relationship between tumor-associated macrophages and pharmacokinetics of liposomal agents in preclinical murine models by Lucas, Andrew T, White, Taylor F, Deal, Allison M, Herity, Leah B, Song, Gina, Santos, Charlene M, Zamboni, William C., PharmD, PhD

“…Abstract The mononuclear phagocyte system (MPS) has previously been shown to significantly affect the clearance, tumor delivery, and efficacy of nanoparticles…”
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Abstract LB-280: High carbohydrate and fat diet hastens tumor growth, increases pro-inflammatory signals and metabolic shifts in a mouse model of basal-like breast cancer by Madduri, Supradeep S., Rezeli, Erika T., Santos, Charlene M., Freeman, Herman L., McRitchie, Susan L., Kirchner, David R., Sumner, Susan J., Hursting, Stephen D., Stewart, Delisha A.

“…Numerous studies have established obesity as an important risk factor for most cancers, but the mechanisms underlying the links between obesity and cancer are…”
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Abstract B21: Suppression of adaptive resistance mechanisms to trametinib by inhibition of BET bromodomains in TNBC by Miller, Samantha M., Zawistowski, Jon S., Stuhlmiller, Timothy J., Sciaky, Noah, Santos, Charlene M., Darr, David B., Johnson, Gary L.

“…The RAF-MEK-ERK signaling pathway regulates the proliferation of Triple Negative Breast Cancer (TNBC). Although MEK inhibition by trametinib in TNBC cell lines…”
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Abstract A03: Several rational combination kinase inhibitor treatments identified by synthetic lethality screens are efficacious in intracranial triple negative breast cancer models by Swearingen, Amanda E.D. Van, Sambade, Maria J., Siegel, Marni B., Sud, Shivani, Bevill, Samantha M., Golitz, Brian T., Bash, Ryan E., Santos, Charlene M., Darr, David B., Parker, Joel S., Miller, C. Ryan, Johnson, Gary L., Anders, Carey K.

“…Introduction: Nearly half of metastatic triple negative breast cancer (TNBC) patients develop brain metastases (BMs) and face a poor prognosis. There are no…”
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Abstract 2579: Combination therapy with MEK inhibition is efficacious in intracranial triple negative breast cancer models by Van Swearingen, Amanda E.D., Siegel, Marni B., Sambade, Maria J., Sud, Shivani, Miller, Samantha M., Silva, Grace, Bash, Ryan E., Santos, Charlene M., Darr, David B., Golitz, Brian, Parker, Joel S., Miller, C. Ryan, Johnson, Gary L., Anders, Carey K.

“…Introduction: Nearly half of metastatic triple negative breast cancer (TNBC) patients develop brain metastases (BM) and face a poor prognosis. The blood-brain…”
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Abstract 3354: Relationship between tumor-associated macrophages (TAMs), tumor delivery, and efficacy of PEGylated liposomal doxorubicin (PLD) and non-liposomal doxorubicin (NL-doxo) in genetically engineered mouse models (GEMMs) of breast cancer (BC) by Song, Gina, Darr, David B., Santos, Charlene M., White, Taylor F., Jordan, Jamie L., Kim, Mimi, Midkiff, Bentley R., Feinberg, Nana N., Miller, Ryan, Rogers, Arlin B., Dudley, Andrew C., Perou, Charles M., Zamboni, William C.

“…Introduction: Solid tumors consist of both malignant cells and non-malignant stromal cells. Stromal cells typically include vascular, mesenchymal, and…”
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