Administration of Lactobacillus plantarum Lp62 to dam rats at the end of delivery and during lactation affects TGF-β1 level and nutritional milk composition, and body weight of pups

Purpose Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat’s pups; on yield, cytokines and milk composition was studied. Methods Lactob...

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Published in:	European journal of nutrition Vol. 58; no. 3; pp. 1137 - 1146
Main Authors:	Messias, Gladistone Correia, Rocha, Ana Marta Novais, Santos, Beatriz Manuela Silva, Botelho, Ana Marques, Silva, Dhaísa Cristhina Alves, Porto, Erika Santos, dos Anjos, Marina Lima, Sousa, Rayra Almeida, Silva, Mara Viana, da Rocha, Thainara Barros, de Melo, Aracely Vieira, Carneiro, Manoela Rios Trindade, Aguiar, Nayonara Santana, Santos, Patrícia Prado, de Souza, Erika Pereira, Cruz, Mariluze Peixoto, Marques, Lucas Miranda, Rezende, Raquel Passos, Romano, Carla Cristina, Uetanabaro, Ana Paula, Vinderola, Gabriel, Yatsuda, Regiane
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2019 Springer Nature B.V
Subjects:	Administration, Oral Animals Animals, Newborn Animals, Suckling Bacteria Beans Body weight Body Weight - drug effects Breastfeeding & lactation Chemistry Chemistry and Materials Science Cholesterol Cocoa Colorimetry Cytokines Dietary supplements Enzyme-linked immunosorbent assay Female Glands Lactation Lactation - drug effects Lactation - metabolism Lactic acid Lactic acid bacteria Lactobacillus plantarum Lactose Milk Models, Animal Nutrition Oral administration Original Contribution Pregnancy Pregnancy, Animal Probiotics Rats Rats, Wistar Rodents Transforming Growth Factor beta1 - drug effects Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Triglycerides Probiotic Rats Immunology Pups Milk Lactobacillus plantarum
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Summary:	Purpose Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat’s pups; on yield, cytokines and milk composition was studied. Methods Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans. It was administered daily by gavage to Wistar rats ( n = 8), from the 7th day before delivery and for 20 days during lactation, in a concentration of 1.44 × 10 9 CFU/rat. The dam and pups were weighed and milk was collected at 12th and 19th day for determination of protein, triglycerides, cholesterol and lactose by colorimetric assays. TGF-β1 milk levels were analyzed by ELISA. The mammary glands of rats were removed for histological analysis. To detect statistical differences between the groups, tests of mean differences at a significance level of 5% was performed. Results S upplementation with L. plantarum L62 resulted in significant higher weight of pups ( p < 0.05), with similar weight on dams ( p > 0.05). The milk yield was not altered by L. plantarum treatment, but the levels of protein, triglycerides and cholesterol were increased ( p < 0.05), with no difference in lactose concentration ( p > 0.05). Levels of TGF-β1 were higher in the milk of L. plantarum treatment ( p < 0.05). Conclusions The treatment of dams at the end of pregnancy and lactation with L. plantarum Lp62 increased nutritional content of milk, probably contributing to the higher weight of the pups. The higher levels of TGF-β1 in the milk, could promote immune benefits to the pups. Further studies in this field are needed to prove the potential use of L. plantarum Lp62 as a probiotic.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1436-6207 1436-6215
DOI:	10.1007/s00394-018-1628-y