Search Results - "Santos, Antônio Cardozo"

Brazilian Green Propolis’ Artepillin C and Its Acetylated Derivative Activate the NGF‐Signaling Pathways and Induce Neurite Outgrowth in NGF‐Deprived PC12 Cells by Rocha Caldas, Gabriel, Amaral, Lilian, Munhoz Rodrigues, Débora, Mayrink de Miranda, Aline, Aparecida Guinaim dos Santos, Neife, Machado Rocha, Leandro, Tame Parreira, Renato Luis, Cardozo dos Santos, Antônio, Kenupp Bastos, Jairo

“…Artepillin C is the most studied compound in Brazilian Green Propolis and, along with its acetylated derivative, displays neurotrophic activity on PC12 cells…”
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Doxycycline inhibits dopaminergic neurodegeneration through upregulation of axonal and synaptic proteins by do Amaral, Lilian, dos Santos, Neife Aparecida Guinaim, Sisti, Flávia Malvestio, Del Bel, Elaine, dos Santos, Antônio Cardozo

“…Doxycycline (DOX) is a widely used antibiotic that is able to cross the blood–brain barrier. Several studies have shown its neuroprotective effect against…”
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Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents by Santos, Neife Aparecida Guinaim dos, Ferreira, Rafaela Scalco, Santos, Antonio Cardozo dos

“…Cisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this…”
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The antibiotic doxycycline mimics the NGF signaling in PC12 cells: A relevant mechanism for neuroprotection by Amaral, Lilian do, Santos, Neife Aparecida Guinaim dos, Sisti, Flávia Malvestio, Del Bel, Elaine, Santos, Antônio Cardozo dos

“…Doxycycline has been used as antibiotic since the 1960s. Recently, studies have shown that doxycycline is neuroprotective in models of neurodegenerative…”
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The neuroprotection of cannabidiol against MPP+-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease by Santos, Neife Aparecida Guinaim, Martins, Nádia Maria, Sisti, Flávia Malvestio, Fernandes, Laís Silva, Ferreira, Rafaela Scalco, Queiroz, Regina Helena Costa, Santos, Antônio Cardozo

“…Cannabidiol (CBD) is a non-psychoactive constituent of Cannabis sativa with potential to treat neurodegenerative diseases. Its neuroprotection has been mainly…”
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The cannabinoid beta-caryophyllene (BCP) induces neuritogenesis in PC12 cells by a cannabinoid-receptor-independent mechanism by Santos, Neife Aparecida Guinaim, Martins, Nádia Maria, Sisti, Flávia Malvestio, Fernandes, Laís Silva, Ferreira, Rafaela Scalco, de Freitas, Osvaldo, Santos, Antônio Cardozo

“…Beta-caryophyllene (BCP) is a phytocannabinoid whose neuroprotective activity has been mainly associated with selective activation of cannabinoid-type-2 (CB2)…”
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Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update by dos Santos, Neife Aparecida Guinaim, Carvalho Rodrigues, Maria Augusta, Martins, Nadia Maria, dos Santos, Antonio Cardozo

“…Cisplatin is a highly effective antitumor agent whose clinical application is limited by the inherent nephrotoxicity. The current measures of nephroprotection…”
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Dual effects of S‐adenosyl‐methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP by Cantelmo, Rebeca Araujo, Santos, Neife Aparecida G., Santos, Antonio Cardozo, Joca, Sâmia Regiane Lourenço

“…Objectives To investigate S‐adenosyl‐methyonine (SAM) effects on PC12 cells viability and neuritogenesis treated with MPP+ (1‐methyl‐4‐phenylpyridinium)…”
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Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway by Bernardes, Carolina Petri, Lopes Pinheiro, Ernesto, Ferreira, Isabela Gobbo, de Oliveira, Isadora Sousa, Dos Santos, Neife Aparecida Guinaim, Sampaio, Suely Vilela, Arantes, Eliane Candiani, Dos Santos, Antonio Cardozo

“…Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. There is no effective treatment for neurodegenerative diseases. Snake venoms…”
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Caffeic acid phenethyl ester (CAPE) protects PC12 cells from MPP+ toxicity by inducing the expression of neuron-typical proteins by Santos, Neife Aparecida Guinaim dos, Martins, Nádia Maria, Silva, Roberto de Barros, Ferreira, Rafaela Scalco, Sisti, Flávia Malvestio, Santos, Antonio Cardozo dos

“…•Total inhibition of neuritogenesis is an early step in the neurotoxicity of MPP+.•CAPE induces neuritogenesis and synaptogenesis in non-NGF-stimulated PC12…”
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Effect of diabetes on biodistribution, nephrotoxicity and antitumor activity of cisplatin in mice by da Silva Faria, Marcia C., Santos, Neife A.G. dos, Carvalho Rodrigues, Maria A., Rodrigues, Jairo Lisboa, Barbosa Junior, Fernando, Santos, Antonio Cardozo dos

“…•A mouse model bearing a tumor, diabetes and nephrotoxicity was developed.•Diabetes decreases the platinum accumulation in multiple organs and tumor.•Diabetes…”
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Carvedilol protects the kidneys of tumor-bearing mice without impairing the biodistribution or the genotoxicity of cisplatin by Carvalho Rodrigues, Maria A., Santos, Neife A.G. dos, da Silva Faria, Marcia C., Rodrigues, Jairo Lisboa, Kinoshita, Angela, Baffa, Oswaldo, Antunes, Lusania M. Greggi, Barbosa, Fernando, Gobe, Glenda C., Santos, Antonio Cardozo dos

“…Cisplatin (Cisp) is an effective antitumor drug; however, it causes severe nephrotoxicity. Minimization of renal toxicity is essential, but the interference of…”
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Baccharin from Brazilian green propolis induces neurotrophic signaling pathways in PC12 cells: potential for axonal and synaptic regeneration by do Amaral, Lilian, Caldas, Gabriel Rocha, dos Santos, Neife Aparecida Guinaim, Parreira, Renato Luis Tame, Bastos, Jairo Kennup, dos Santos, Antonio Cardozo

“…Neurodegenerative diseases are characterized by progressive loss of the structure and function of specific neuronal populations, and have been associated with…”
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In vitro study of the neuropathic potential of the organophosphorus compounds trichlorfon and acephate by Fernandes, Laís S., Emerick, Guilherme L., Santos, Neife Aparecida G. dos, de Paula, Eloísa Silva, Barbosa, Fernando, Santos, Antonio Cardozo dos

“…•Trichlorfon is a potential inducer of delayed neuropathy (OPIDN).•Trichlorfon interferes on neuritogenesis and calcium in SH-SY5Y cells.•The in vitro effects…”
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L- and T-type calcium channel blockers protect against the inhibitory effects of mipafox on neurite outgrowth and plasticity-related proteins in SH-SY5Y cells by Fernandes, Laís Silva, Dos Santos, Neife Aparecida G., Emerick, Guilherme Luz, Santos, Antonio Cardozo Dos

“…Some organophosphorus compounds (OP), including the pesticide mipafox, produce late onset distal axonal degeneration, known as organophosphorus-induced delayed…”
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Non-cytotoxic Concentration of Cisplatin Decreases Neuroplasticity-Related Proteins and Neurite Outgrowth Without Affecting the Expression of NGF in PC12 Cells by Ferreira, Rafaela Scalco, dos Santos, Neife Aparecida Guinaim, Martins, Nádia Maria, Fernandes, Laís Silva, dos Santos, Antonio Cardozo

“…Cisplatin is the most effective and neurotoxic platinum chemotherapeutic agent. It induces a peripheral neuropathy characterized by distal axonal degeneration…”
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High concentration of trichlorfon (1mM) disrupts axonal cytoskeleton and decreases the expression of plasticity-related proteins in SH-SY5Y cells by Fernandes, Laís Silva, Emerick, Guilherme Luz, Ferreira, Rafaela Scalco, Santos, Neife Aparecida G. dos, Santos, Antonio Cardozo dos

“…Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to…”
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Coenzyme Q10 and its effects in the treatment of neurodegenerative diseases by Santos, Graciela Cristina dos, Antunes, Lusânia Maria Greggi, Santos, Antonio Cardozo dos, Bianchi, Maria de Lourdes Pires

“…According to clinical and pre-clinical studies, oxidative stress and its consequences may be the cause or, at least, a contributing factor, to a large number…”
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In vitro study of the neuropathic potential of the organophosphorus compounds fenamiphos and profenofos: Comparison with mipafox and paraoxon by Emerick, Guilherme L., Fernandes, Laís S., de Paula, Eloísa Silva, Barbosa, Fernando, Santos, Neife Aparecida Guinaim dos, Santos, Antonio Cardozo dos

“…•Mipafox had the lowest IC50 and induced the highest percentage of aging of NTE.•Only mipafox was able to cause calpain activation after 24h of…”
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Effects of nimesulide and its reduced metabolite on mitochondria by Mingatto, Fábio Erminio, Dos Santos, Antonio Cardozo, Rodrigues, Tiago, Pigoso, Acácio Antonio, Uyemura, Sérgio Akira, Curti, Carlos

“…We investigated the effects of nimesulide, a recently developed non‐steroidal anti‐inflammatory drug, and of a metabolite resulting from reduction of the nitro…”
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