LaSap vaccine: Immunotherapy and immunochemotherapy associated with allopurinol in dogs naturally infected with Leishmania infantum

LaSap vaccine: Immunotherapy and immunochemotherapy associated with allopurinol in dogs naturally infected with Leishmania infantum

Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs stable for long periods, and the risk of generating parasitic resistance must be considered. Forty‐four symptomatic and nat...

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Published in:Parasite immunology Vol. 46; no. 2; pp. e13028 - n/a
Main Authors: Clasta, Ricardo B., Rivas, Açucena Veleh, Souza, Adrieli Barboza, Santos, Angelo G. V., Le Quesne, Andrés Hernán Mojoli, Gonçalves, Ana Alice Maia, Cangussu, Alex Sander R., Giunchetti, Rodolfo C., Viana, Kelvinson F.
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-02-2024
Subjects:
Allopurinol
canine visceral leishmaniasis
immunochemotherapy
Immunotherapy
Leishmania infantum
Parasitism
Public health
Vaccines
Visceral leishmaniasis
canine visceral leishmaniasis
immunochemotherapy
immunotherapy
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Summary:Canine visceral leishmaniasis is a parasitic zoonosis that has a profound impact on public health in countries where it is endemic. Chemotherapeutic treatments cannot keep dogs stable for long periods, and the risk of generating parasitic resistance must be considered. Forty‐four symptomatic and naturally infected dogs with Leishmania infantum were tested with two treatment protocols (i) immunotherapy with LaSap vaccine and (ii) immunochemotherapy with LaSap vaccine plus allopurinol. At 90 days after the end of the treatment, it was verified that, although both protocols had generated significant clinical improvements with a greater production of IFN‐γ/IL‐10, in relation to the parasite load, mainly in the skin, the dogs treated only with immunotherapy maintained the same profile. These results indicate that LaSap is a good strategy to control dog parasitism.
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ISSN:0141-9838
1365-3024
DOI:10.1111/pim.13028