Search Results - "Santoro, SA"

The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis by Chen, Jianchun, Diacovo, Thomas G, Grenache, David G, Santoro, Samuel A, Zutter, Mary M

“…The alpha(2)beta(1) integrin is a collagen/laminin receptor expressed on platelets, endothelial cells, fibroblasts, and epithelial cells. To define the role of…”
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beta 1 Integrin Mediates Internalization of Mammalian Reovirus by Maginnis, Melissa S, rest, JCraig, Kopecky-Bromberg, Sarah A, Dickeson, SKent, Santoro, Samuel A, Zutter, Mary M, Nemerow, Glen R, Bergelson, Jeffrey M, Dermody, Terence S

“…Reovirus infection is initiated by interactions between the attachment protein sigma 1 and cell surface carbohydrate and junctional adhesion molecule A…”
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Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen by Dumin, J A, Dickeson, S K, Stricker, T P, Bhattacharyya-Pakrasi, M, Roby, J D, Santoro, S A, Parks, W C

“…In injured skin, collagenase-1 (matrix metalloproteinase-1 (MMP-1)) is induced in migrating keratinocytes. This site-specific expression is regulated by…”
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Novel collectin/C1q receptor mediates mast cell activation and innate immunity by Edelson, Brian T., Stricker, Thomas P., Li, Zhengzhi, Dickeson, S. Kent, Shepherd, Virginia L., Santoro, Samuel A., Zutter, Mary M.

“…Mast cells play a critical role in innate immunity, allergy, and autoimmune diseases. The receptor/ligand interactions that mediate mast cell activation are…”
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The nature of interactions between tissue-type plasminogen activator and platelets by Torr, S R, Winters, K J, Santoro, S A, Sobel, B E

“…To elucidate interactions responsible for inhibition of aggregation of platelets in platelet-rich plasma (PRP) harvested from whole blood preincubated with…”
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Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance by Love, P E, Santoro, S A

“…To determine the prevalence of lupus anticoagulant and anticardiolipin in systemic lupus erythematosus (SLE) and in non-SLE disorders, and to evaluate the…”
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alpha 2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK by Klekotka, P A, Santoro, S A, Zutter, M M

“…The alpha(2) integrin subunit cytoplasmic domain uniquely supported epidermal growth factor (EGF)-stimulated migration on type I collagen. p38 MAP kinase- and…”
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Platelet Surface Collagen Receptor Polymorphisms: Variable Receptor Expression and Thrombotic/Hemorrhagic Risk by Santoro, Samuel A.

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Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction by Stricker, T P, Dumin, J A, Dickeson, S K, Chung, L, Nagase, H, Parks, W C, Santoro, S A

“…Previous studies have established that ligation of keratinocyte alpha(2)beta(1) integrin by type I collagen induces expression of matrix metalloproteinase-1…”
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Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen, and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived From the Cell-Binding Domain of Fibronectin by Haverstick, Doris M., Cowan, Joseph F., Yamada, Kenneth M., Santoro, Samuel A.

“…The role in platelet function of the cell-binding region of fibronectin was explored by the use of synthetic peptides. The prototypical peptide…”
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Determinants of ligand binding specificity of the alpha(1)beta(1) and alpha(2)beta(1) integrins by Dickeson, S K, Mathis, N L, Rahman, M, Bergelson, J M, Santoro, S A

“…The alpha(1)beta(1) and alpha(2)beta(1) integrins are cell surface collagen receptors. Cells expressing the alpha(1)beta(1) integrin preferentially adhere to…”
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Ligand recognition by the I domain-containing integrins by Dickeson, S K, Santoro, S A

“…Seven of the integrin alpha subunits described to date, alpha 1, alpha 2, alpha L, alpha X, alpha d, alpha M and alpha E, contain a highly conserved I (or A)…”
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Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen by Santoro, S A

“…Platelets initially adhere to collagen via a divalent cation-dependent process supported by Mg2+, Mn2+, Fe2+, Cu2+, Zn2+, or Co2+ more rapidly and to a greater…”
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The impact of heparin concentration and activated clotting time monitoring on blood conservation: A prospective, randomized evaluation in patients undergoing cardiac operation by Despotis, G. J, Joist, J. H, Hogue, C. W., Jr, Alsoufiev, A, Kater, K, Goodnough, L. T, Santoro, S. A, Spitznagel, E, Rosenblum, M, Lappas, D. G

“…A whole blood hemostasis system (Hepcon) provides both activated clotting time and accurate whole blood heparin concentration measurements via an automated…”
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Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis by Saelman, E U, Keely, P J, Santoro, S A

“…Cellular interactions with collagen in a model of kidney tubulogenesis were investigated using Madin-Darby canine kidney (MDCK) cells in an in vitro…”
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Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen by Staatz, W D, Fok, K F, Zutter, M M, Adams, S P, Rodriguez, B A, Santoro, S A

“…The alpha 2 beta 1 integrin serves as either a specific cell surface receptor for collagen or as both a collagen and laminin receptor depending upon the cell…”
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Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain by Klekotka, P A, Santoro, S A, Ho, A, Dowdy, S F, Zutter, M M

“…The alpha(2)beta(1) integrin supports cell-cycle progression of mammary epithelial cells adherent to type I collagen matrices. Integrin collagen receptors…”
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ERK and p38 MAP Kinase Pathways Are Mediators of Intestinal Epithelial Wound-Induced Signal Transduction by Dieckgraefe, Brian K., Weems, Danielle M., Santoro, Samuel A., Alpers, David H.

“…Repair of gastrointestinal epithelial injury involves cell migration, proliferation, and specific gene expression. The pathways responsible for epithelial…”
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Widespread histologic distribution of the alpha 2 beta 1 integrin cell- surface collagen receptor by Zutter, MM, Santoro, SA

“…The alpha 2 beta 1 integrin (platelet membrane glycoprotein Ia-IIa, VLA-2, ECMR-II) functions as a cell surface receptor for collagen. The authors have…”
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Location, location, location: targeting the endothelium by Santoro, Samuel A., Stricker, Thomas P.

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