Evaluation of thermal-oxidative stability and antiglioma activity of Zanthoxylum tingoassuiba essential oil entrapped into multi- and unilamellar liposomes

Zanthoxylum tinguassuiba essential oil (ZtEO) contains α-bisabolol, a known antiglioma sesquiterpene, among other potentially active substances. Medical applications of this essential oil require advances in the design of distinctive carriers due to its low water solubility and easy degradation by h...

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Bibliographic Details
Published in:	Journal of liposome research Vol. 22; no. 1; pp. 1 - 7
Main Authors:	Detoni, Cassia B., de Oliveira, Diêgo Madureira, Santo, Islane E., Pedro, André São, El-Bacha, Ramon, da Silva Velozo, Eudes, Ferreira, Domingos, Sarmento, Bruno, de Magalhães Cabral-Albuquerque, Elaine C.
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 01-03-2012 Taylor & Francis
Subjects:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects brain-cell viability Cell Survival - drug effects Drug delivery Drug Screening Assays, Antitumor Drug Stability Glioblastoma - drug therapy Glioblastoma - pathology liposomes Liposomes - chemistry Molecular Structure Oils, Volatile - chemistry Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Oxidation-Reduction Plant Components, Aerial - chemistry Solubility Structure-Activity Relationship Temperature thermoanalysis volatile oil Zanthoxylum - chemistry
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Summary:	Zanthoxylum tinguassuiba essential oil (ZtEO) contains α-bisabolol, a known antiglioma sesquiterpene, among other potentially active substances. Medical applications of this essential oil require advances in the design of distinctive carriers due to its low water solubility and easy degradation by heat, light, and oxygen. The aim of this work was to evaluate enhancement in oxidative stability and the ability to reduce glioblastoma cell viability of ZtEO loaded into liposomes. Multi- and unilamellar vesicles were prepared to carry ZtEO. By using thermal analysis, it was observed that thermal-oxidative stability of the liposomal ZtEO was enhanced, when compared to its free form. Liposomal ZtEO also presented significant apoptotic-inducing activity for glioma cells. These results show that liposomal systems carrying ZtEO may be a potential alternative for gliobastoma treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0898-2104 1532-2394
DOI:	10.3109/08982104.2011.573793