Search Results - "Santiveri, Clara M"

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies by San José-Enériz, Edurne, Agirre, Xabier, Rabal, Obdulia, Vilas-Zornoza, Amaia, Sanchez-Arias, Juan A., Miranda, Estibaliz, Ugarte, Ana, Roa, Sergio, Paiva, Bruno, Estella-Hermoso de Mendoza, Ander, Alvarez, Rosa María, Casares, Noelia, Segura, Victor, Martín-Subero, José I., Ogi, François-Xavier, Soule, Pierre, Santiveri, Clara M., Campos-Olivas, Ramón, Castellano, Giancarlo, de Barrena, Maite Garcia Fernandez, Rodriguez-Madoz, Juan Roberto, García-Barchino, Maria José, Lasarte, Juan Jose, Avila, Matias A, Martinez-Climent, Jose Angel, Oyarzabal, Julen, Prosper, Felipe

“…The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this…”
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Interaction Networks in Protein Folding via Atomic-Resolution Experiments and Long-Time-Scale Molecular Dynamics Simulations by Sborgi, Lorenzo, Verma, Abhinav, Piana, Stefano, Lindorff-Larsen, Kresten, Cerminara, Michele, Santiveri, Clara M, Shaw, David E, de Alba, Eva, Muñoz, Victor

“…The integration of atomic-resolution experimental and computational methods offers the potential for elucidating key aspects of protein folding that are not…”
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Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1 by Göttgens, Berthold, Bycroft, Mark, Bonadies, Nicolas, Santiveri, Clara M, Kvinlaug, Brynn T, Allen, Mark D, Freund, Stefan M V, Vezzoli, Alessandro, Huntly, Brian J P

“…Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important…”
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Structural basis for interdomain communication in SHIP2 providing high phosphatase activity by Le Coq, Johanne, Camacho-Artacho, Marta, Velázquez, José Vicente, Santiveri, Clara M, Gallego, Luis Heredia, Campos-Olivas, Ramón, Dölker, Nicole, Lietha, Daniel

“…SH2-containing-inositol-5-phosphatases (SHIPs) dephosphorylate the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P ) and play important…”
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Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children by Comella-del-Barrio, Patricia, Izquierdo-Garcia, José Luis, Gautier, Jacqueline, Doresca, Mariette Jean Coute, Campos-Olivas, Ramón, Santiveri, Clara M., Muriel-Moreno, Beatriz, Prat-Aymerich, Cristina, Abellana, Rosa, Pérez-Porcuna, Tomas M., Cuevas, Luis E., Ruiz-Cabello, Jesús, Domínguez, José

“…Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and…”
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Context-Dependence of the Contribution of Disulfide Bonds to β-Hairpin Stability by Santiveri, Clara M., León, Esther, Rico, Manuel, Jiménez, M. Angeles

“…Incorporation of disulfide bonds to stabilize protein and peptide structures is not always a successful strategy. To advance current knowledge on the…”
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Two Singular Types of CCCH Tandem Zinc Finger in Nab2p Contribute to Polyadenosine RNA Recognition by Martínez-Lumbreras, Santiago, Santiveri, Clara M., Mirassou, Yasmina, Zorrilla, Silvia, Pérez-Cañadillas, José Manuel

“…The seven C-terminal CCCH-type zinc fingers of Nab2p bind the poly(A) tail of mRNA (∼A25). Using NMR, we demonstrated that the first four (Zf1–Zf4) contain two…”
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Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site by Santiveri, Clara M, Mirassou, Yasmina, Rico-Lastres, Palma, Martínez-Lumbreras, Santiago, Pérez-Cañadillas, José Manuel

“…Pub1p, a highly abundant poly(A)+ mRNA binding protein in Saccharomyces cerevisiae, influences the stability and translational control of many cellular…”
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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation by García-Alonso, Sara, Mesa, Pablo, Ovejero, Laura de la Puente, Aizpurua, Gonzalo, Lechuga, Carmen G., Zarzuela, Eduardo, Santiveri, Clara M., Sanclemente, Manuel, Muñoz, Javier, Musteanu, Mónica, Campos-Olivas, Ramón, Martínez-Torrecuadrada, Jorge, Barbacid, Mariano, Montoya, Guillermo

“…RAF kinases are RAS-activated enzymes that initiate signaling through the MAPK cascade to control cellular proliferation, differentiation, and survival. Here,…”
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Tryptophan residues: Scarce in proteins but strong stabilizers of β-hairpin peptides by Santiveri, Clara M., Jiménez, M. Angeles

“…Tryptophan plays important roles in protein stability and recognition despite its scarcity in proteins. Except as fluorescent groups, they have been used…”
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The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition by Franco-Echevarría, Elsa, González-Polo, Noelia, Zorrilla, Silvia, Martínez-Lumbreras, Santiago, Santiveri, Clara M, Campos-Olivas, Ramón, Sánchez, Mar, Calvo, Olga, González, Beatriz, Pérez-Cañadillas, José Manuel

“…Transcription termination of non-coding RNAs is regulated in yeast by a complex of three RNA binding proteins: Nrd1, Nab3 and Sen1. Nrd1 is central in this…”
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Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses by Balzano, Deborah, Fawal, Mohamad-Ali, Velázquez, Jose V., Santiveri, Clara M., Yang, Joshua, Pastor, Joaquín, Campos-Olivas, Ramón, Djouder, Nabil, Lietha, Daniel

“…Protein kinase B (PKB/Akt) is an important mediator of signals that control various cellular processes including cell survival, growth, proliferation, and…”
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Structural basis of Nrd1-Nab3 heterodimerization by Chaves-Arquero, Belén, Martínez-Lumbreras, Santiago, Camero, Sergio, Santiveri, Clara M, Mirassou, Yasmina, Campos-Olivas, Ramón, Jiménez, Maria Ángeles, Calvo, Olga, Pérez-Cañadillas, José Manuel

“…Heterodimerization of RNA binding proteins Nrd1 and Nab3 is essential to communicate the RNA recognition in the nascent transcript with the Nrd1 recognition of…”
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Nuclear Magnetic Resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members by Santiveri, Clara M., Sborgi, Lorenzo, de Alba, Eva

“…According to biochemical assays, the Bcl‐2 protein Diva from mouse regulates programmed cell death by heterodimerizing with other members of the family and by…”
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Disulfide bonds versus TrpTrp pairs in irregular beta-hairpins: NMR structure of vammin loop 3-derived peptides as a case study by Mirassou, Yasmina, Santiveri, Clara M, Pérez de Vega, M Jesús, González-Muñiz, Rosario, Jiménez, M Angeles

“…Structural studies on model peptides have led to a good understanding of the rules behind the formation and stability of regular beta-hairpins. To test their…”
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Sequence Inversion and Phenylalanine Surrogates at the β-Turn Enhance the Antibiotic Activity of Gramicidin S by Solanas, Concepción, de la Torre, Beatriz G, Fernández-Reyes, María, Santiveri, Clara M, Jiménez, M. Ángeles, Rivas, Luis, Jiménez, Ana I, Andreu, David, Cativiela, Carlos

“…A series of gramicidin S (GS) analogues have been synthesized where the Phe (i + 1) and Pro (i + 2) residues of the β-turn have been swapped while the…”
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A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helix by León, Esther, Navarro-Avilés, Gloria, Santiveri, Clara M, Flores-Flores, Cesar, Rico, Manuel, González, Carlos, Murillo, Francisco J, Elías-Arnanz, Montserrat, Jiménez, María Angeles, Padmanabhan, S

“…Direct targeting of critical DNA-binding elements of a repressor by its cognate antirepressor is an effective means to sequester the repressor and remove a…”
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Therapeutic Index of Gramicidin S is Strongly Modulated by d-Phenylalanine Analogues at the β-Turn by Solanas, Concepción, de la Torre, Beatriz G, Fernández-Reyes, María, Santiveri, Clara M, Jiménez, M. Ángeles, Rivas, Luis, Jiménez, Ana I, Andreu, David, Cativiela, Carlos

“…Analogues of the cationic antimicrobial peptide gramicidin S (GS), cyclo(Val-Orn-Leu-d-Phe-Pro)2, with d-Phe residues replaced by different (restricted…”
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De novo design of monomeric beta-hairpin and beta-sheet peptides by Pantoja-Uceda, David, Santiveri, Clara M, Jiménez, M Angeles

“…Since the first report in 1993 (JACS 115, 5887-5888) of a peptide able to form a monomeric beta-hairpin structure in aqueous solution, the design of peptides…”
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Factors involved in the stability of isolated β‐sheets: Turn sequence, β‐sheet twisting, and hydrophobic surface burial by Santiveri, Clara M., Santoro, Jorge, Rico, Manuel, Jiménez, M. Angeles

“…We have recently reported on the design of a 20‐residue peptide able to form a significant population of a three‐stranded up‐and‐down antiparallel β‐sheet in…”
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